2022
Performance of current risk stratification models for predicting mortality in patients with heart failure: a systematic review and meta-analysis
Siddiqi TJ, Ahmed A, Greene SJ, Shahid I, Usman MS, Oshunbade A, Alkhouli M, Hall ME, Murad MH, Khera R, Jain V, Van Spall HGC, Khan MS. Performance of current risk stratification models for predicting mortality in patients with heart failure: a systematic review and meta-analysis. European Journal Of Preventive Cardiology 2022, 29: 2027-2048. PMID: 35919956, DOI: 10.1093/eurjpc/zwac148.Peer-Reviewed Original ResearchConceptsChronic heart failureLong-term mortalityMid-term mortalityAcute HFHeart failureRisk scoreGeneric inverse variance random effects modelInverse variance random-effects modelCurrent risk stratification modelsExcellent discriminationAcute heart failureRisk stratification modelShort-term mortalityLack of headRandom-effects modelGood discriminationAHF mortalityCause mortalityC-statisticNineteen studiesPatientsMortality predictionSystematic reviewHead comparisonMortality
2018
Early coronary angiography and survival after out-of-hospital cardiac arrest: a systematic review and meta-analysis
Khera R, CarlLee S, Blevins A, Schweizer M, Girotra S. Early coronary angiography and survival after out-of-hospital cardiac arrest: a systematic review and meta-analysis. Open Heart 2018, 5: e000809. PMID: 30402255, PMCID: PMC6203043, DOI: 10.1136/openhrt-2018-000809.Peer-Reviewed Original ResearchEarly coronary angiographyFavorable neurological outcomeCoronary angiographyHospital cardiac arrestNeurological outcomeCardiac arrestQ testAcute myocardial infarctionConcurrent control groupMultiple electronic databasesRandom-effects modelCochran's Q testSurvival outcomesMyocardial infarctionObservational studyCommon causePooled estimatesHigher oddsExposure groupOHCAAngiographyStudy heterogeneityControl groupElectronic databasesSystematic reviewEffects of Weight-Loss Medications on Cardiometabolic Risk Profiles: A Systematic Review and Network Meta-analysis
Khera R, Pandey A, Chandar AK, Murad MH, Prokop LJ, Neeland IJ, Berry JD, Camilleri M, Singh S. Effects of Weight-Loss Medications on Cardiometabolic Risk Profiles: A Systematic Review and Network Meta-analysis. Gastroenterology 2018, 154: 1309-1319.e7. PMID: 29305933, PMCID: PMC5880739, DOI: 10.1053/j.gastro.2017.12.024.Peer-Reviewed Original ResearchConceptsWeight loss medicationsCardiometabolic risk profileHigh-density lipoprotein cholesterolWaist circumferenceDrug AdministrationSystematic reviewRisk profileLipoprotein cholesterolHemoglobin A1cObese adultsCholesterol profileSystolic/diastolic BPCardiometabolic risk factorsNetwork Meta-AnalysisRandomized clinical trialsQuality of evidenceLow-density lipoproteinModest decreaseOutcomes of interestEffect of foodLong-term useMinimal effectLiraglutide useOrlistat useBlood pressure
2016
Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis
Dulai PS, Singh S, Marquez E, Khera R, Prokop LJ, Limburg PJ, Gupta S, Murad MH. Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis. The BMJ 2016, 355: i6188. PMID: 27919915, PMCID: PMC5137632, DOI: 10.1136/bmj.i6188.Peer-Reviewed Original ResearchConceptsLow-dose aspirinNon-aspirin NSAIDsMetachronous neoplasiaDose aspirinColorectal neoplasiaColorectal cancerChemoprevention agentsSystematic reviewCandidate agentCandidate chemoprevention agentsMetachronous colorectal cancerHigh-dose aspirinPrimary efficacy outcomeSerious adverse eventsEfficacy of agentsQuality of evidenceWeb of ScienceEfficacy outcomesAdverse eventsFavorable riskSafety profileBenefit profileClinical trialsGRADE criteriaSafety outcomesComparative Effectiveness of Pharmacologic Interventions for Pulmonary Arterial Hypertension A Systematic Review and Network Meta-Analysis
Jain S, Khera R, Girotra S, Badesch D, Wang Z, Murad MH, Blevins A, Schmidt GA, Singh S, Gerke AK. Comparative Effectiveness of Pharmacologic Interventions for Pulmonary Arterial Hypertension A Systematic Review and Network Meta-Analysis. CHEST Journal 2016, 151: 90-105. PMID: 27615023, PMCID: PMC5310124, DOI: 10.1016/j.chest.2016.08.1461.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionEndothelin receptor antagonistsArterial hypertensionPharmacologic interventionsFunctional statusNew York Heart Association/World Health Organization functional classWorld Health Organization functional classSystematic reviewFuture comparative-effectiveness trialDiscontinuation of therapyA Systematic ReviewComparative effectiveness trialNetwork Meta-AnalysisPatient-centered approachClinical worseningCochrane RegisterSubcutaneous prostanoidsEfficacy outcomesPlacebo groupPlacebo ratesAdverse eventsReceptor antagonistPharmacologic agentsEffectiveness trialComparative efficacyAssociation of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis
Khera R, Murad MH, Chandar AK, Dulai PS, Wang Z, Prokop LJ, Loomba R, Camilleri M, Singh S. Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis. JAMA 2016, 315: 2424-2434. PMID: 27299618, PMCID: PMC5617638, DOI: 10.1001/jama.2016.7602.Peer-Reviewed Original ResearchConceptsAdverse eventsClinical trialsWeight lossObese adultsHigher oddsAdverse event-related treatment discontinuationSystematic reviewSignificant excess weight lossCumulative ranking (SUCRA) probabilitiesDiscontinuation of therapyExcess weight lossProportion of patientsManagement of obesityQuality of evidenceWeight loss agentsWeb of ScienceTreatment discontinuationCochrane CENTRALPharmacological treatmentMagnitude of decreaseGRADE criteriaDrug treatmentLiraglutideMAIN OUTCOMEPlacebo participants
2015
Pacemaker Dependency after Cardiac Surgery: A Systematic Review of Current Evidence
Steyers CM, Khera R, Bhave P. Pacemaker Dependency after Cardiac Surgery: A Systematic Review of Current Evidence. PLOS ONE 2015, 10: e0140340. PMID: 26470027, PMCID: PMC4607414, DOI: 10.1371/journal.pone.0140340.Peer-Reviewed Original ResearchConceptsPermanent pacemaker implantationPacemaker dependencyCardiac surgeryPacemaker implantationRisk factorsSystematic reviewAV conduction diseasePerioperative risk factorsPostoperative conduction disturbancesProcedure-specific variablesWeb of ScienceConduction disturbancesEmbase databasesConduction diseaseAV conductionExclusion criteriaCurrent evidencePredetermined inclusionSurgeryPatientsComprehensive searchSignificant heterogeneityIndividual studiesUniform definitionImplantation