Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsTony Tiganis
Professor AdjunctAbout
Research
Publications
2026
A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging
Xirouchaki C, García-Domínguez E, Coughlan E, McGrath M, Giri S, Liang S, Wiede F, Bigot A, Sadoshima J, Gomez-Cabrera M, Philp A, Moberg M, Apró W, Roman W, Mitchell C, Tiganis T. A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging. Science Advances 2026, 12: eadz1953. PMID: 42268956, PMCID: PMC13251858, DOI: 10.1126/sciadv.adz1953.Peer-Reviewed Original Research
2025
Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer
Ooms L, Ferguson D, Rodgers S, Sukhija K, Jones E, Csolle M, Yip H, Daly R, Tiganis T, McLean C, Papa A, Mitchell C. Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer. Communications Biology 2025, 9: 96. PMID: 41408399, PMCID: PMC12827249, DOI: 10.1038/s42003-025-09364-2.Peer-Reviewed Original ResearchTargeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models
Du X, Goh P, Ma C, Coughlan E, Greatorex S, Porter L, Russ B, Cummins K, Sek K, Slaney C, Scott A, Oliaro J, Neeson P, Risbridger G, Taylor R, Trapani J, Turner S, Darcy P, Wiede F, Tiganis T. Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models. Science Translational Medicine 2025, 17: eadk0627. PMID: 41160667, DOI: 10.1126/scitranslmed.adk0627.Peer-Reviewed Original ResearchMechanisms, functions and therapeutic targeting of protein tyrosine phosphatases
Tiganis T, Tonks N. Mechanisms, functions and therapeutic targeting of protein tyrosine phosphatases. Nature Reviews Molecular Cell Biology 2025, 27: 129-152. PMID: 41028199, DOI: 10.1038/s41580-025-00882-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsA consensus guide to preclinical indirect calorimetry experiments
Banks A, Allison D, Alquier T, Ansarullah, Austad S, Auwerx J, Ayala J, Baur J, Carobbio S, Churchill G, Dall M, de Cabo R, Donato J, Dragano N, Elias C, Ferrante A, Finck B, Galgani J, Gerhart-Hines Z, Goodyear L, Grobe J, Gupta R, Habegger K, Hartig S, Hevener A, Heymsfield S, Holman C, de Angelis M, James D, Kazak L, Kim J, Klingenspor M, Kong X, Kooijman S, Lantier L, Lloyd K, Lo J, Lodhi I, MacLean P, McGuinness O, Medina-Gómez G, Mirmira R, Morrison C, Morton G, Müller T, Ogawa Y, Pajuelo-Reguera D, Potthoff M, Qi N, Reitman M, Rensen P, Rozman J, Rutkowsky J, Sakamoto K, Scherer P, Schwartz G, Sedlacek R, Selloum M, Shaikh S, Chen S, Shulman G, Škop V, Soukas A, Speakman J, Spiegelman B, Steinberg G, Svensson K, Thyfault J, Tiganis T, Titchenell P, Turner N, Velloso L, Vidal-Puig A, Ward C, Williams A, Wolfrum C, Xu A, Xu Y, Zierath J. A consensus guide to preclinical indirect calorimetry experiments. Nature Metabolism 2025, 7: 1765-1780. PMID: 40993210, PMCID: PMC12974399, DOI: 10.1038/s42255-025-01360-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsProtein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics
Bennett A, Tiganis T. Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics. Annual Review Of Physiology 2025, 87: 301-324. PMID: 39531392, DOI: 10.1146/annurev-physiol-022724-105540.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2024
miR-33 deletion in hepatocytes attenuates NAFLD-NASH-HCC progression
Fernández-Tussy P, Cardelo M, Zhang H, Sun J, Price N, Boutagy N, Goedeke L, Cadena-Sandoval M, Xirouchaki C, Brown W, Yang X, Pastor-Rojo O, Haeusler R, Bennett A, Tiganis T, Suárez Y, Fernández-Hernando C. miR-33 deletion in hepatocytes attenuates NAFLD-NASH-HCC progression. JCI Insight 2024, 9: e168476. PMID: 39190492, PMCID: PMC11466198, DOI: 10.1172/jci.insight.168476.Peer-Reviewed Original Research
2023
Mitochondrial- and NOX4-dependent antioxidant defence mitigates progression to non-alcoholic steatohepatitis in obesity
Greatorex S, Kaur S, Xirouchaki C, Goh P, Wiede F, Genders A, Tran M, Jia Y, Raajendiran A, Brown W, McLean C, Sadoshima J, Watt M, Tiganis T. Mitochondrial- and NOX4-dependent antioxidant defence mitigates progression to non-alcoholic steatohepatitis in obesity. Journal Of Clinical Investigation 2023, 134: e162533. PMID: 38060313, PMCID: PMC10849767, DOI: 10.1172/jci162533.Peer-Reviewed Original Research