Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsMatthias Tschoep, MD
About
Research
Publications
2026
FGF21 reduces ER stress by enhancing the unfolded protein and integrated stress responses through increased sulfide signaling
Grandl G, König A, Metzger F, Liskiewicz A, Hefele T, Nason S, Novikoff A, Al-Refaie N, Rahman M, Khalil A, Zhang Q, Collden G, Finan B, Douros J, Habegger K, Cebrian-Serrano A, Hauck S, Tschöp M, Müller T. FGF21 reduces ER stress by enhancing the unfolded protein and integrated stress responses through increased sulfide signaling. Cell Metabolism 2026 PMID: 42302784, DOI: 10.1016/j.cmet.2026.05.011.Peer-Reviewed Original ResearchAuthor Correction: Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments
Becker M, Kälin S, Neubig A, Lauber M, Opaleva D, Hipp H, Salb V, Ott V, Legutko B, Kälin R, Hippich M, Scherm M, Nascimento L, Serr I, Hosp F, Nikolaev A, Mohebiany A, Krueger M, Flachmeyer B, Pfaffl M, Haase B, Yi C, Dietzen S, Bopp T, Woods S, Waisman A, Weigmann B, Mann M, Tschöp M, Daniel C. Author Correction: Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments. Nature Communications 2026, 17: 4414. PMID: 42151187, PMCID: PMC13184267, DOI: 10.1038/s41467-026-73173-2.Commentaries, Editorials and LettersPublisher Correction: GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
Liskiewicz D, Novikoff A, Khalil A, Akindehin S, Campbell J, Candela P, Castelino R, Coupland C, Culot M, Dodson W, Douros J, Embring H, Feuchtinger A, Finan B, Garcia-Caceres C, Gao X, Gosselet F, Grandl G, Gutgesell R, Haas D, Jastroch M, Karaoglu E, Kakimoto P, Kaltenbach A, Keuper M, Kusminski C, Leander D, Liskiewicz A, Liu X, Maity-Kumar G, Martinez S, Mowery S, Nogueiras R, Paisley M, Perez-Tilve D, Petersen P, Pfluger P, Prakash S, Steffens S, Cebrian-Serrano A, Tost M, Wean J, Weber C, Yoshida J, Gerhart-Hines Z, Horvath T, Scherer P, Seeley R, DiMarchi R, Tschöp M, Krahmer N, Knerr P, Müller T. Publisher Correction: GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice. Nature 2026, 654: e11-e11. PMID: 42151694, PMCID: PMC13233300, DOI: 10.1038/s41586-026-10619-z.Commentaries, Editorials and LettersGLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
Liskiewicz D, Novikoff A, Khalil A, Akindehin S, Campbell J, Candela P, Castelino R, Coupland C, Culot M, Dodson W, Douros J, Embring H, Feuchtinger A, Finan B, Garcia-Caceres C, Gao X, Gosselet F, Grandl G, Gutgesell R, Haas D, Jastroch M, Karaoglu E, Kakimoto P, Kaltenbach A, Keuper M, Kusminski C, Leander D, Liskiewicz A, Liu X, Maity-Kumar G, Martinez S, Mowery S, Nogueiras R, Paisley M, Perez-Tilve D, Petersen P, Pfluger P, Prakash S, Steffens S, Cebrian-Serrano A, Tost M, Wean J, Weber C, Yoshida J, Gerhart-Hines Z, Horvath T, Scherer P, Seeley R, DiMarchi R, Tschöp M, Krahmer N, Knerr P, Müller T. GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice. Nature 2026, 653: 776-785. PMID: 42056522, PMCID: PMC13190304, DOI: 10.1038/s41586-026-10427-5.Peer-Reviewed Original ResearchGIPR:GCGR co-agonism restores normal weight in obese rodents
Perez-Tilve D, Zhang F, Zhang Y, Lohman K, Sorrell J, Vick A, Müller T, Tschöp M, DiMarchi R. GIPR:GCGR co-agonism restores normal weight in obese rodents. Molecular Metabolism 2026, 108: 102365. PMID: 41997446, PMCID: PMC13141540, DOI: 10.1016/j.molmet.2026.102365.Peer-Reviewed Original ResearchGlucagon-like receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits
Nauck M, Tuttle K, Tschöp M, Blüher M. Glucagon-like receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits. The Lancet 2026, 407: 892-908. PMID: 41547366, DOI: 10.1016/s0140-6736(25)02105-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2025
Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice
Gutgesell R, Khalil A, Liskiewicz A, Maity-Kumar G, Novikoff A, Grandl G, Liskiewicz D, Coupland C, Karaoglu E, Akindehin S, Castelino R, Curion F, Liu X, Garcia-Caceres C, Cebrian-Serrano A, Douros J, Knerr P, Finan B, DiMarchi R, Sloop K, Samms R, Theis F, Tschöp M, Müller T. Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice. Nature Metabolism 2025, 7: 1299-1299. PMID: 40360757, PMCID: PMC12198006, DOI: 10.1038/s42255-025-01308-8.Commentaries, Editorials and LettersGIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice
Gutgesell R, Khalil A, Liskiewicz A, Maity-Kumar G, Novikoff A, Grandl G, Liskiewicz D, Coupland C, Karaoglu E, Akindehin S, Castelino R, Curion F, Liu X, Garcia-Caceres C, Cebrian-Serrano A, Douros J, Knerr P, Finan B, DiMarchi R, Sloop K, Samms R, Theis F, Tschöp M, Müller T. GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice. Nature Metabolism 2025, 7: 1282-1298. PMID: 40301583, PMCID: PMC12198009, DOI: 10.1038/s42255-025-01294-x.Peer-Reviewed Original ResearchEstrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism
Coupland C, Sun N, Khalil A, Karaoglu Ö, Liskiewicz A, Liskiewicz D, Grandl G, Akindehin S, Maity G, Yang B, Finan B, Knerr P, Douros J, Walch A, DiMarchi R, Tschöp M, Müller T, Novikoff A. Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism. Molecular Metabolism 2025, 96: 102136. PMID: 40204014, PMCID: PMC12032945, DOI: 10.1016/j.molmet.2025.102136.Peer-Reviewed Original ResearchA once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans
Finan B, Douros J, Goldwater R, Hansen A, Hjerpsted J, Hjøllund K, Kankam M, Knerr P, Konkar A, Mowery S, Müller T, Nielsen J, Nygård S, Perez-Tilve D, Raun K, Yang B, Tschöp M, DiMarchi R. A once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans. Molecular Metabolism 2025, 96: 102129. PMID: 40139439, PMCID: PMC12051155, DOI: 10.1016/j.molmet.2025.102129.Peer-Reviewed Original Research