Luis Garcia-Segura, PhD
About
Research
Publications
2024
Neuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle
Cioffi L, Diviccaro S, Chrostek G, Caruso D, Garcia-Segura L, Melcangi R, Giatti S. Neuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 243: 106590. PMID: 39053702, DOI: 10.1016/j.jsbmb.2024.106590.Peer-Reviewed Original ResearchNeuroactive steroidsMenstrual cycleNervous systemEstrous cycleRat estrous cycleNeuroactive steroid levelsLevels of pregnenoloneSex steroid hormone levelsOvarian cycleRegulation of nervous functionsPeripheral nervous systemSteroid hormone levelsPsychiatric disordersSteroid patternBrain regionsHormone levelsTherapeutic consequencesNeuropathological eventsPeripheral nervesSteroid levelsNeuroprotective agentsNervous functionSteroidsPhysiological regulationProgesteroneAging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Bautista-Abad Á, García-Magro N, Pinto-Benito D, Cáceres-Pajuelo J, Alises C, Ganchala D, Lagunas N, Negredo P, García-Segura L, Arevalo M, Grassi D. Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input. GeroScience 2024, 1-14. PMID: 38954130, DOI: 10.1007/s11357-024-01268-z.Peer-Reviewed Original ResearchExpression of aromataseTrigeminal ganglionPain perceptionAndrogen receptorEstrogen receptorSensory neuronsDorsal root ganglia sensory neuronsIncreased expression of aromataseIncidence of trigeminal neuralgiaAged female animalsAssociated with sex-specific alterationsPresence of aromataseModulate pain perceptionRegulating pain perceptionSex-specific alterationsInvolvement of aromataseSex-specific mannerTrigeminal neuralgiaGene expressionFemale miceAromatase immunoreactivitySomatosensory inputEstrogen synthesisAR geneSex differencesGonadal hormone deprivation regulates response to tibolone in neurodegenerative pathways
McGovern A, Arevalo M, Ciordia S, Garcia-Segura L, Barreto G. Gonadal hormone deprivation regulates response to tibolone in neurodegenerative pathways. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 241: 106520. PMID: 38614433, DOI: 10.1016/j.jsbmb.2024.106520.Peer-Reviewed Original ResearchHormone therapyEfficacy of hormone therapyEffects of hormone therapyPathways of neurodegenerationBilateral oophorectomyHormone deprivationAndrogen pathwayIncreased risk of neurodegenerationTherapeutic efficacyTiboloneOxidative phosphorylationIncreased riskProteomic analysisCalcium signalingCellular respirationHormonal declineNeurodegenerative pathwaysDrug typeRisk of neurodegenerationInterconnected pathwaysPathwayNeurodegenerationSexSex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model
Cioffi L, Grassi D, Diviccaro S, Caruso D, Pinto-Benito D, Arevalo M, Garcia-Segura L, Melcangi R, Giatti S. Sex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 241: 106514. PMID: 38554982, DOI: 10.1016/j.jsbmb.2024.106514.Peer-Reviewed Original ResearchSex chromosome complementChromosome complementGenotype mouse modelNeuroactive steroid levelsNeuroactive steroidsMouse modelSteroid levelsSex chromosomesSRY geneSexual dimorphism levelsSex determinationContribution of sex chromosome complementTissue-specific actionsGonadsLiquid chromatography-tandem mass spectrometryGonadal hormonesChromatography-tandem mass spectrometryNeuroprotective actionSteroidsSexual featuresLevel regulationNervous systemSex-specificGenotypesComplement
1999
O-085. Modulation of synapses during sexual differentiation of the brain
Naftolin F, Horvath T, Garcia-Segura L. O-085. Modulation of synapses during sexual differentiation of the brain. Human Reproduction 1999, 14: 46-47. DOI: 10.1093/humrep/14.suppl_3.46-a.Peer-Reviewed Original Research
1996
Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge
Naftolin F, Mor G, Horvath T, Luquin S, Fajer A, Kohen F, Garcia-Segura L. Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge. Endocrinology 1996, 137: 5576-5580. DOI: 10.1210/en.137.12.5576.Peer-Reviewed Original ResearchPreovulatory gonadotropin surgeArcuate nucleusGonadotropin surgeSynaptic retractionMorning of metestrusEstrous cycleMorning of estrusAxosomatic synapsesPhysiological synaptic plasticitySurge of gonadotropinsPreovulatory estradiol surgePreovulatory LH surgeEstradiol surgeCirculating estradiolHypothalamic mechanismsPreovulatory levelsEstrogen diethylstilbestrolSynaptic plasticityLH surgeSynaptic remodelingGonadotropinEstrogenMidcycleMorphological eventsOvarian cycleA45 The effects of estrogen on primate brain circuitry
Naftolin F, Horvath T, Garcia-Segura L. A45 The effects of estrogen on primate brain circuitry. Maturitas 1996, 27: 14. DOI: 10.1016/s0378-5122(97)80881-x.Peer-Reviewed Original Research