Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsLuis Garcia-Segura, PhD
About
Research
Publications
2025
Sex-specific gonadal status determines prefrontal cortex proteome response to tibolone
McGovern A, Arevalo M, Ciordia S, Garcia-Segura L, Barreto G. Sex-specific gonadal status determines prefrontal cortex proteome response to tibolone. Biomedicine & Pharmacotherapy 2025, 190: 118419. PMID: 40779885, DOI: 10.1016/j.biopha.2025.118419.Peer-Reviewed Original ResearchPrefrontal cortexHormone therapyCellular stress response pathwaysStress response pathwaysFemale miceFunctional enrichment analysisSex-SpecificEmotion regulationClinical trialsCytoskeletal functionBrain functionMitochondrial metabolismSex differencesMenopausal hormone therapyResponse pathwaysGonadal hormonesProteomic analysisSynaptic plasticityEnrichment analysisNeurotransmitter signalingMolecular mechanismsFunctional convergenceGonadectomized animalsHormone therapy efficacyNeurodegenerative diseasesRole of Serum Brain‐Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults
Ortolá R, Sotos‐Prieto M, Carballo‐Casla A, Cabello‐Plan S, Koni A, Mustieles V, García‐Segura L, Artalejo A, Rodríguez‐Artalejo F, García‐Esquinas E. Role of Serum Brain‐Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults. European Journal Of Pain 2025, 29: e70014. PMID: 40222813, PMCID: PMC11994381, DOI: 10.1002/ejp.70014.Peer-Reviewed Original ResearchConceptsSerum brain-derived neurotrophic factorBrain-derived neurotrophic factorChronic painBrain-derived neurotrophic factor concentrationsDepression statusCommunity-dwelling individualsMental health differencesControl of confoundingChronic pain diagnosesElectronic medical recordsSpanish general populationBiomarkers of chronic painNeurotrophic factorNon-depressed participantsHealth differencesMusculoskeletal painInterference painOlder adultsPain surveyPain diagnosisPain severityGeneral populationDepressed womenPain subtypesCP evaluation
2024
Tibolone treatment after traumatic brain injury exerts a sex-specific and Y chromosome-dependent regulation of methylation and demethylation enzymes and estrogen receptors in the cerebral cortex
Pinto-Benito D, Bautista-Abad A, Lagunas N, Ontiveros N, Ganchala D, Garcia-Segura L, Arevalo M, Grassi D. Tibolone treatment after traumatic brain injury exerts a sex-specific and Y chromosome-dependent regulation of methylation and demethylation enzymes and estrogen receptors in the cerebral cortex. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2024, 1871: 167532. PMID: 39366643, DOI: 10.1016/j.bbadis.2024.167532.Peer-Reviewed Original ResearchNeuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle
Cioffi L, Diviccaro S, Chrostek G, Caruso D, Garcia-Segura L, Melcangi R, Giatti S. Neuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 243: 106590. PMID: 39053702, DOI: 10.1016/j.jsbmb.2024.106590.Peer-Reviewed Original ResearchNeuroactive steroidsMenstrual cycleNervous systemEstrous cycleRat estrous cycleNeuroactive steroid levelsLevels of pregnenoloneSex steroid hormone levelsOvarian cycleRegulation of nervous functionsPeripheral nervous systemSteroid hormone levelsPsychiatric disordersSteroid patternBrain regionsHormone levelsTherapeutic consequencesNeuropathological eventsPeripheral nervesSteroid levelsNeuroprotective agentsNervous functionSteroidsPhysiological regulationProgesteroneAging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Bautista-Abad Á, García-Magro N, Pinto-Benito D, Cáceres-Pajuelo J, Alises C, Ganchala D, Lagunas N, Negredo P, García-Segura L, Arevalo M, Grassi D. Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input. GeroScience 2024, 46: 6459-6472. PMID: 38954130, PMCID: PMC11493896, DOI: 10.1007/s11357-024-01268-z.Peer-Reviewed Original ResearchExpression of aromataseTrigeminal ganglionPain perceptionAndrogen receptorEstrogen receptorSensory neuronsDorsal root ganglia sensory neuronsIncreased expression of aromataseIncidence of trigeminal neuralgiaAged female animalsAssociated with sex-specific alterationsPresence of aromataseModulate pain perceptionRegulating pain perceptionSex-specific alterationsInvolvement of aromataseSex-specific mannerTrigeminal neuralgiaGene expressionFemale miceAromatase immunoreactivitySomatosensory inputEstrogen synthesisAR geneSex differencesGonadal hormone deprivation regulates response to tibolone in neurodegenerative pathways
McGovern A, Arevalo M, Ciordia S, Garcia-Segura L, Barreto G. Gonadal hormone deprivation regulates response to tibolone in neurodegenerative pathways. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 241: 106520. PMID: 38614433, DOI: 10.1016/j.jsbmb.2024.106520.Peer-Reviewed Original ResearchHormone therapyEfficacy of hormone therapyEffects of hormone therapyPathways of neurodegenerationBilateral oophorectomyHormone deprivationAndrogen pathwayIncreased risk of neurodegenerationTherapeutic efficacyTiboloneOxidative phosphorylationIncreased riskProteomic analysisCalcium signalingCellular respirationHormonal declineNeurodegenerative pathwaysDrug typeRisk of neurodegenerationInterconnected pathwaysPathwayNeurodegenerationSexSex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model
Cioffi L, Grassi D, Diviccaro S, Caruso D, Pinto-Benito D, Arevalo M, Garcia-Segura L, Melcangi R, Giatti S. Sex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 241: 106514. PMID: 38554982, DOI: 10.1016/j.jsbmb.2024.106514.Peer-Reviewed Original ResearchSex chromosome complementChromosome complementGenotype mouse modelNeuroactive steroid levelsNeuroactive steroidsMouse modelSteroid levelsSex chromosomesSRY geneSexual dimorphism levelsSex determinationContribution of sex chromosome complementTissue-specific actionsGonadsLiquid chromatography-tandem mass spectrometryGonadal hormonesChromatography-tandem mass spectrometryNeuroprotective actionSteroidsSexual featuresLevel regulationNervous systemSex-SpecificGenotypesComplement
2023
SEX AND AGE DIFFERENCES IN THE EXPRESSION OF GENES ENCODING FOR ESTRADIOL SYNTHESIS AND SIGNALING IN THE MOUSE TRIGEMINAL GANGLION
Bautista-Abad Á, Magro N, Cáceres-Pajuelo J, Alises C, Segura L, Arévalo M, Negredo P, Grassi D. SEX AND AGE DIFFERENCES IN THE EXPRESSION OF GENES ENCODING FOR ESTRADIOL SYNTHESIS AND SIGNALING IN THE MOUSE TRIGEMINAL GANGLION. IBRO Neuroscience Reports 2023, 15: s669. DOI: 10.1016/j.ibneur.2023.08.1343.Peer-Reviewed Original Research
2021
Tibolone restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis
Mancino D, Lima A, Roig P, Segura L, De Nicola A, Garay L. Tibolone restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis. Journal Of Neuroendocrinology 2021, 34: e13078. PMID: 34961984, DOI: 10.1111/jne.13078.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisHigh mobility group box protein 1Autoimmune encephalomyelitisExperimental autoimmune encephalomyelitis spinal cordMouse experimental autoimmune encephalomyelitisMS-related inflammationMobility group box protein 1Menopausal hormone therapyEstrogen receptor expressionMultiple sclerosisModel of MSFemale C57BL/6 miceChronic progressive inflammationReal-time polymerase chain reactionTissue-specific actionsCentral nervous systemNLR family pyrin domainHormone therapyReceptor expressionImmune-mediatedTibolone treatmentC57BL/6 miceProgressive inflammationWestern blot analysisFamily pyrin domain
2007
La reconversión del Instituto Cajal
Borrell J, Ferrús A, Segura L. La reconversión del Instituto Cajal. Arbor 2007, CLXXXIII: 793-802. DOI: 10.3989/arbor.2007.i727.142.Peer-Reviewed Original Research