2024
Identification of Glandular (Acinar)/Tubule Formation in Invasive Carcinoma of the Breast: A Study to Determine Concordance Using the World Health Organization Definition.
Lo Y, Lester S, Ellis I, Lanjewar S, Laurini J, Patel A, Bhattarai A, Ustun B, Harmon B, Kleer C, Ross D, Amin A, Wang Y, Bradley R, Turashvili G, Zeng J, Baum J, Singh K, Hakima L, Harigopal M, Komforti M, Shin S, Abbott S, Jaffer S, Badve S, Khoury T, D'Alfonso T, Ginter P, Collins V, Towne W, Gan Y, Nassar A, Sahin A, Flieder A, Aldrees R, Ngo M, Edema U, Sapna F, Schnitt S, Fineberg S. Identification of Glandular (Acinar)/Tubule Formation in Invasive Carcinoma of the Breast: A Study to Determine Concordance Using the World Health Organization Definition. Archives Of Pathology & Laboratory Medicine 2024, 148: 1119-1125. PMID: 38244086, DOI: 10.5858/arpa.2023-0163-oa.Peer-Reviewed Original ResearchInvasive breast cancerWorld Health Organization definitionNottingham grading systemOrganization definitionMedian concordance rateMicropapillary carcinomaMucinous carcinomaInvasive carcinomaBreast pathologistsBreast cancerConcordance rateGrading systemCarcinomaTubulesPathologistsBreastConcordanceProfessor EllisCancerCases
2023
Breast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review
Carrasco-Tenezaca F, Moreira-Dinzey J, Manrai P, Bearse M, Burela S, Podany P, Singh K, Pareja F, Zheng J, Muscato N, Liang Y, Zhan H, Krishnamurti U, Dolezal D, Wang J, Harigopal M. Breast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review. International Journal Of Surgical Pathology 2023, 32: 1037-1045. PMID: 37908113, DOI: 10.1177/10668969231209780.Peer-Reviewed Original ResearchBreast carcinomaTubulopapillary featuresHuman epidermal growth factor 2 (HER2) expressionBreast cancer histologic subtypesNonmetastatic breast carcinomaTriple-negative profileHigh-grade nuclear featuresTriple-negative carcinomasHigh-grade featuresMetastatic breast carcinomaGrowth factor 2 expressionFactor 2 expressionReports of tumorsMicropapillary projectionsNeoadjuvant therapyHistologic subtypeWorse prognosisFirst tumorPoor prognosisAdditional tumorsInvasive carcinomaEstrogen receptorCarcinomaPathogenic variantsTumorsSignificance of Myoepithelial Cell Layer in Breast Ductal Carcinoma in situ With Papillary Architecture With and Without Associated Invasive Carcinoma
Golestani R, Singh K, Karam P, Pinto M, Liang Y, Orsaria M, Harigopal M. Significance of Myoepithelial Cell Layer in Breast Ductal Carcinoma in situ With Papillary Architecture With and Without Associated Invasive Carcinoma. Clinical Breast Cancer 2023, 23: 91-100. DOI: 10.1016/j.clbc.2022.09.006.Peer-Reviewed Original ResearchSolid papillary carcinomaPapillary DCISInvasive carcinomaMyoepithelial cellsPapillary architecturePapillary carcinomaConventional invasive carcinomaFoci of DCISPapillary breast lesionsAssociated invasive carcinomaBreast ductal carcinomaME cellsMyoepithelial cell layerCell layerMedian followDistant metastasisHistologic evidenceDuctal carcinomaME cell layersPathology databasePapillary componentRetrospective searchResults MajorityCarcinomaDCIS
2022
Evaluation of TRPS1 Expression in Pleural Effusion Cytology Specimens With Metastatic Breast Carcinoma
Wang M, Stendahl K, Cai G, Adeniran A, Harigopal M, Gilani SM. Evaluation of TRPS1 Expression in Pleural Effusion Cytology Specimens With Metastatic Breast Carcinoma. American Journal Of Clinical Pathology 2022, 158: 416-425. PMID: 35760555, DOI: 10.1093/ajcp/aqac066.Peer-Reviewed Original ResearchConceptsTrichorhinophalangeal syndrome type 1Breast originMetastatic carcinomaTRPS1 expressionBreast primaryBreast carcinomaPrimary siteMC casesMetastatic breast carcinomaSquamous cell carcinomaPleural effusion cytologySyndrome type 1Cell block materialStrong nuclear expressionEffusion cytology specimensCell carcinomaUrothelial carcinomaIHC panelMalignant melanomaLung adenocarcinomaIHC stainingPositive stainingCytology specimensCarcinomaEffusion cytologyCytomorphologic features of SMARCA4‐deficient non–small cell lung carcinoma and correlation with immunohistochemical and molecular features
Sun T, Gilani SM, Podany P, Harigopal M, Zhong M, Wang H. Cytomorphologic features of SMARCA4‐deficient non–small cell lung carcinoma and correlation with immunohistochemical and molecular features. Cancer Cytopathology 2022, 130: 620-629. PMID: 35468657, DOI: 10.1002/cncy.22581.Peer-Reviewed Original ResearchConceptsNon-small cell lung carcinomaCell lung carcinomaCytomorphologic featuresLung carcinomaExtensive antibody panelHigh-grade featuresCommon cytologic featuresDifferent anatomic sitesVariable expressionMajority of casesSquamoid featuresCo-mutated genesUndifferentiated carcinomaImmunohistochemical profileGlandular featuresPapillary architectureAnatomic sitesCytologic featuresAggressive carcinomasClinical informationAntibody panelEpithelial markersScant cytoplasmCarcinomaNuclear enlargement
2019
Interobserver variability in breast carcinoma grading results in prognostic stage differences
Rabe K, Snir OL, Bossuyt V, Harigopal M, Celli R, Reisenbichler ES. Interobserver variability in breast carcinoma grading results in prognostic stage differences. Human Pathology 2019, 94: 51-57. PMID: 31655171, DOI: 10.1016/j.humpath.2019.09.006.Peer-Reviewed Original ResearchConceptsPathologic prognostic stagePrognostic stageStage II carcinomaInterobserver variabilityIntra-observer variabilityGood intra-observer variabilityStage IABreast pathologistsConsecutive casesTumor gradeBreast carcinomaTumor gradingDiscordant gradesAJCC cancerDiscordant casesCarcinoma gradeInterobserver agreementGrading criteriaPathologistsCarcinomaComplete concordanceGradeOverall gradeGrading results
2018
Strong androgen receptor expression can aid in distinguishing GATA3+ metastases
Boto A, Harigopal M. Strong androgen receptor expression can aid in distinguishing GATA3+ metastases. Human Pathology 2018, 75: 63-70. PMID: 29408697, DOI: 10.1016/j.humpath.2018.01.024.Peer-Reviewed Original ResearchConceptsGATA3-positive tumorsAndrogen receptor expressionBreast originMetastatic settingUrothelial originAR expressionAR stainingAndrogen receptorReceptor expressionBreast cancerUnknown originBreast cancer tissue microarrayMarker of breastStrong AR expressionCancer tissue microarrayMammaglobin expressionUrothelial carcinomaLobular carcinomaProgesterone receptorEstrogen receptorTissue microarrayMammary originCarcinomaGATA3 expressionGATA3
2016
Metastatic thyroid carcinoma presenting as malignant pleural effusion: A cytologic review of 5 cases
Vyas M, Harigopal M. Metastatic thyroid carcinoma presenting as malignant pleural effusion: A cytologic review of 5 cases. Diagnostic Cytopathology 2016, 44: 1085-1089. PMID: 27456348, DOI: 10.1002/dc.23547.Peer-Reviewed Original ResearchConceptsMetastatic thyroid carcinomaThyroid transcription factor-1Pleural fluidThyroid carcinomaMalignant pleural effusionPleural effusionTranscription factor 1Thyroid originImmunohistochemical stainsLung adenocarcinomaCarcinomaRight diagnosisUseful markerClinical contextDiagnosisFactor 1ThyroglobulinMarkersAdenocarcinomaEffusionMalignancy
2003
Reporting needle core biopsies of breast carcinomas
Hoda S, Harigopal M, Harris G, Pinder S, Lee A, Ellis I. Reporting needle core biopsies of breast carcinomas. Histopathology 2003, 43: 84-90. PMID: 12823716, DOI: 10.1046/j.1365-2559.2003.01625.x.Peer-Reviewed Original Research