Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children
Barcelona V, Huang Y, Caceres BA, Newhall KP, Hui Q, Cerdeña JP, Crusto CA, Sun YV, Taylor JY. Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children. International Journal Of Molecular Sciences 2022, 23: 8951. PMID: 36012217, PMCID: PMC9408935, DOI: 10.3390/ijms23168951.Peer-Reviewed Original ResearchConceptsLife Events Checklist-5Health outcomesAfrican American mothersHigh-risk groupAdverse health outcomesEpigenome-wide DNA methylationChronic diseasesUnipolar depressionAmerican mothersMental illnessAssociation of experienceTranslational approachDNA methylationChildhood traumaTraumaExperience scoresMothersChildrenAssociationExperience of traumaDNA methylation profilesOutcomesEpigenetic changesTraumatic experiencesLongitudinal researchThe Interaction of Trauma Exposure and DNA Methylation on Blood Pressure Among Black Women in the InterGEN Study
Caceres B, Huang Y, Barcelona V, Wang Z, Newhall K, Cerdeña J, Crusto C, Sun Y, Taylor J. The Interaction of Trauma Exposure and DNA Methylation on Blood Pressure Among Black Women in the InterGEN Study. Epigenetics Insights 2022, 15: 25168657221138510. PMID: 36466626, PMCID: PMC9716582, DOI: 10.1177/25168657221138510.Peer-Reviewed Original ResearchDiastolic blood pressureBlood pressureTrauma exposureHypertension riskBody mass indexChildhood traumaEpigenome-wide significance levelBlack mothersBlack womenSeparate linear mixed-effects modelsMass indexCigarette smokingMean ageHigh riskLinear mixed effects modelsBlack adultsTraumaDNA methylationVicarious traumaEpigenetic mechanismsCpG sitesMixed effects models