2024
Nuclear Cardiology
Zaret B, Wackers F. Nuclear Cardiology. 2024, 3-12. DOI: 10.1093/med/9780190095659.003.0001.Peer-Reviewed Original ResearchEvaluate left ventricular (LV) functionQuantification of coronary blood flowPerfusion imagingRadiation dose reductionPET-FDG studiesStress perfusion imagingEvaluate myocardial perfusionCoronary flow reserveMyocardial perfusion studiesComputed tomography CTCardiac sarcoidosisCoronary blood flowDose reductionMyocardial inflammationSPECT approachAssess prognosisMyocardial stress perfusion imagingStress imagingMyocardial perfusionFlow reservePerfusion studiesCardiac studiesRadionuclide imagingBlood flowAttenuation correctionNuclear Cardiology
Zaret B, Wackers F. Nuclear Cardiology. 2024, 1-1. DOI: 10.1093/med/9780197521434.003.0001.Peer-Reviewed Original ResearchEvaluate left ventricular (LV) functionQuantification of coronary blood flowPerfusion imagingRadiation dose reductionPET-FDG studiesStress perfusion imagingEvaluate myocardial perfusionCoronary flow reserveMyocardial perfusion studiesComputed tomography CTCardiac sarcoidosisCoronary blood flowDose reductionMyocardial inflammationSPECT approachAssess prognosisMyocardial stress perfusion imagingStress imagingMyocardial perfusionFlow reservePerfusion studiesCardiac studiesRadionuclide imagingBlood flowAttenuation correction
2015
Kinetics of Conventional and New Cardiac Radiotracers
Taillefer R, Wackers F. Kinetics of Conventional and New Cardiac Radiotracers. 2015, 58-80. DOI: 10.1093/med/9780199392094.003.0004.Peer-Reviewed Original ResearchMyocardial blood flowDetection of obstructive coronary artery diseaseObstructive coronary artery diseaseBlood flowSympathetic neuronal functionCellular mechanism of uptakeCoronary artery diseaseCardiac imaging protocolImage myocardial perfusionTime of imagingQuantification of regional myocardial blood flowAdjacent organsClinical impactArtery diseaseMyocardial perfusionCardiac imagingCardiac metabolismRegional myocardial blood flowImaging protocolCellular mechanismsNeuronal functionMyocardial extractionCardiac imaging agentMechanism of uptakeImaging agents
1998
Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging.
Wu JC, Yun JJ, Heller EN, Dione DP, DeMan P, Liu YH, Zaret BL, Wackers FJ, Sinusas AJ. Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging. Journal Of Nuclear Medicine 1998, 39: 417-25. PMID: 9529285.Peer-Reviewed Original ResearchConceptsSingle-vessel stenosisMyocardial blood flowDobutamine stressCoronary stenosisTechnetium-99mBlood flowLeft circumflex artery stenosisCircumflex artery stenosisFlow deficitsSingle coronary stenosisCoronary artery diseaseRate-pressure productRegional myocardial blood flowLeft ventricular pressurePeak dobutamine stressOpen-chest dogsNonischemic flowArtery diseaseArtery stenosisPeak dobutamineSestamibi activitySevere stenosisVentricular pressureSestamibi imagingIschemic zone
1996
Quantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model
Liu Y, Sinusas A, Shi C, Shen M, Dione D, Heller E, Wackers F. Quantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model. Journal Of Nuclear Cardiology 1996, 3: 312-320. PMID: 8799250, DOI: 10.1016/s1071-3581(96)90091-4.Peer-Reviewed Original ResearchConceptsMyocardial blood flowRelative blood flowRelative myocardial blood flowRegional myocardial blood flowCoronary artery occlusionBlood flowSingle photon emissionArtery occlusionCanine modelShort-axis slicesEx vivoSestamibi single-photon emissionMyocardial countsFlow deficitsMyocardial count densityNormal blood flowMean countsRegional myocardial perfusionCount profilesMIBI uptakeMIBI SPECTSestamibi SPECTMyocardial perfusionCircumferential count profilesRelative regional myocardial blood flow
1995
Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia.
Shi CQ, Sinusas AJ, Dione DP, Singer MJ, Young LH, Heller EN, Rinker BD, Wackers FJ, Zaret BL. Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia. Journal Of Nuclear Medicine 1995, 36: 1078-86. PMID: 7769431.Peer-Reviewed Original ResearchConceptsIschemic regionMyocardial ischemiaBlood flowEx vivo SPECTRegional myocardial blood flowPartial coronary occlusionMicrosphere blood flowMyocardial blood flowOpen-chest canine modelVivo SPECT imagesSPECT imagesVivo planarCentral ischemic regionCoronary occlusionDemand ischemiaBMS181321Technetium-99mIntravenous injectionLiver ratioMyocardial imagingCanine modelPositive imagingHepatic clearanceLiver activityArterial sampling
1994
Exercise myocardial perfusion imaging.
Wackers F. Exercise myocardial perfusion imaging. Journal Of Nuclear Medicine 1994, 35: 726-9. PMID: 8151402.Peer-Reviewed Original ResearchTechnetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia.
Sinusas AJ, Shi Q, Saltzberg MT, Vitols P, Jain D, Wackers FJ, Zaret BL. Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia. Journal Of Nuclear Medicine 1994, 35: 664-71. PMID: 8151391.Peer-Reviewed Original ResearchConceptsTechnetium-99mCanine modelPerfusion tracerMicrosphere flowCoronary artery occlusionInitial myocardial uptakeIntact canine modelOpen-chest dogsMyocardial perfusion imagingMyocardial blood flowDynamic planar imagingArtery occlusionPharmacological vasodilatationPharmacological stressMyocardial perfusion tracersMyocardial uptakeRadiotracer injectionBlood flowMyocardial perfusionPerfusion imagingArterial samplingMyocardial flowBackground activity ratioTetrofosminIschemia
1989
Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy
Wackers F, Gibbons R, Verani M, Kayden D, Pellikka P, Behrenbeck T, Mahmarian J, Zaret B. Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy. Journal Of The American College Of Cardiology 1989, 14: 861-873. PMID: 2507612, DOI: 10.1016/0735-1097(89)90456-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorAcute myocardial infarctionPatent infarct-related arteryInfarct-related arteryThallium-201 imagingThrombolytic therapyMyocardial infarctionPlanar technetiumMyocardial perfusionExercise thallium-201 imagingFirst acute myocardial infarctionInfarct-related artery patencyInitial risk areaPersistent coronary occlusionSuccess of reperfusionMyocardial blood flowNew myocardial perfusionTissue-type plasminogen activatorArtery patencyChest painCoronary occlusionRepeat imagingBlood flowInfarctionThallium-201