2018
False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab
Chen PP, Tormey CA, Eisenbarth SC, Torres R, Richardson SS, Rinder HM, Smith BR, Siddon AJ. False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab. American Journal Of Clinical Pathology 2018, 151: 154-163. PMID: 30307483, DOI: 10.1093/ajcp/aqy129.Peer-Reviewed Original ResearchConceptsHealthy donor bloodAlemtuzumab treatmentDonor bloodBone marrowFlow cytometryLight chain restrictionT-cell prolymphocytic leukemiaB-cell neoplasmsLight chain clonalityFlow cytometry analysisAutoimmune diseasesHematologic malignanciesImmunophenotypic analysisChain restrictionAlemtuzumabT cellsB cellsProlymphocytic leukemiaImmunoglobulin G1PatientsMonoclonal antibodiesCytometry analysisSimilar findingsBloodClonal restriction
2004
Flow Cytometric DNA Ploidy Analysis of Peripheral Blood From Patients With Sézary Syndrome
Wang, Li N, Heald P, Fisk JM, Fadare O, Howe JG, McNiff JM, Smith BR. Flow Cytometric DNA Ploidy Analysis of Peripheral Blood From Patients With Sézary Syndrome. American Journal Of Clinical Pathology 2004, 122: 774-782. PMID: 15491974, DOI: 10.1309/8b849fc6phap8fdd.Peer-Reviewed Original ResearchConceptsDNA ploidy studiesNeoplastic T cellsSezary syndromeMinimal residual diseasePloidy studiesResidual diseaseBlood-based diagnosisT cellsBlood samplesCutaneous T-cell lymphoma casesT-cell lymphoma casesCytometric DNA ploidy analysisBlood tumor burdenPeripheral blood samplesLarge cell transformationLow-grade groupDNA ploidy analysisAneuploid cellsSézary syndromeLymph nodesImmunophenotypic findingsTumor burdenPeripheral bloodLymphoma casesAneuploid group
2000
Isolation and flow cytometric analysis of T‐cell‐depleted CD34+ PBPCs
Debelak J, Shlomchik M, Snyder E, Cooper D, Seropian S, McGuirk J, Smith B, Krause D. Isolation and flow cytometric analysis of T‐cell‐depleted CD34+ PBPCs. Transfusion 2000, 40: 1475-1481. PMID: 11134567, DOI: 10.1046/j.1537-2995.2000.40121475.x.Peer-Reviewed Original Research
1997
Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender
Rinder C, Mathew J, Rinder H, Tracey J, Davis E, Smith B. Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender. Translational Research 1997, 129: 592-602. PMID: 9178725, DOI: 10.1016/s0022-2143(97)90193-1.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassOlder patientsT cellsLower lymphocyte numbersPercentage of CD8Total lymphocyte countCardiac surgery patientsPostoperative day 1Age of patientsMononuclear cell subsetsNatural killer cellsExpression of CD11bPatterns of lymphocytesYears of ageEvidence of activationHLADR expressionInfectious complicationsLymphocyte subsetsElderly patientsLymphocyte countSurgery patientsYounger patientsCardiac surgeryLymphocyte numbersKiller cells
1991
Selective Depletion of Bone Marrow T Lymphocytes With Anti-CD5 Monoclonal Antibodies: Effective Prophylaxis for Graft-Versus-Host Disease in Patients With Hematologic Malignancies
Antin J, Bierer B, Smith B, Ferrara J, Guinan E, Sieff C, Golan D, Macklis R, Tarbell N, Lynch E, Reichert T, Blythman H, Bouloux C, Rappeport J, Burakoff S, Weinstein H. Selective Depletion of Bone Marrow T Lymphocytes With Anti-CD5 Monoclonal Antibodies: Effective Prophylaxis for Graft-Versus-Host Disease in Patients With Hematologic Malignancies. Blood 1991, 78: 2139-2149. PMID: 1717080, DOI: 10.1182/blood.v78.8.2139.2139.Peer-Reviewed Original ResearchConceptsAnti-CD5 MoAbHigh-risk patientsGraft failureHost diseaseHematologic malignanciesT cellsEpstein-Barr virus-associated lymphoproliferative disorderBone marrowActuarial event-free survivalBone marrow T lymphocytesAnti-CD5 monoclonal antibodyDiagnosis of myelodysplasiaMarrow T lymphocytesEvent-free survivalLow-risk patientsLate graft failureTotal body irradiationSignificant risk factorsRisk of relapseMajor histocompatibility complexActuarial survivalAcute graftAcute GVHDChronic GVHDEvaluable patients
1990
Depletion of bone marrow T-lymphocytes with an anti-CD5 monoclonal immunotoxin (ST-1 immunotoxin): effective prophylaxis for graft-versus-host disease.
Antin JH, Bierer BE, Smith BR, Guinan EC, Provost MM, Ferrara J, Macklis RM, Tarbell NJ, Blythman H, Bouloux C. Depletion of bone marrow T-lymphocytes with an anti-CD5 monoclonal immunotoxin (ST-1 immunotoxin): effective prophylaxis for graft-versus-host disease. Progress In Clinical And Biological Research 1990, 333: 207-15. PMID: 1689852.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntibodies, MonoclonalAntigens, CDAntigens, DifferentiationBone MarrowBone Marrow CellsBone Marrow TransplantationCD5 AntigensChildChild, PreschoolCombined Modality TherapyCyclophosphamideCytarabineDrug EvaluationGraft vs Host DiseaseHumansImmunotoxinsLeukemiaMiddle AgedMyelodysplastic SyndromesRicinRisk FactorsT-LymphocytesWhole-Body Irradiation
1987
Retarded recovery of functional T cell frequencies in T cell-depleted bone marrow transplant recipients.
Daley J, Rozans M, Smith B, Burakoff S, Rappeport J, Miller R. Retarded recovery of functional T cell frequencies in T cell-depleted bone marrow transplant recipients. Blood 1987, 70: 960-4. PMID: 3307954, DOI: 10.1182/blood.v70.4.960.bloodjournal704960.Peer-Reviewed Original ResearchConceptsT cell-depleted bone marrowT cell frequenciesUntreated marrowT cellsBone marrowCell frequencyFunctional T cell compartmentBone marrow transplant recipientsDonor T cellsMonoclonal antibodies Leu-1Marrow transplant recipientsReactive T cellsT cell compartmentT lymphocyte precursorsCompetent T lymphocytesTransplant recipientsMarrow transplantationT lymphocytesLymphocyte precursorsLeu-1Neoplastic cellsMarrowPatientsRecipientsTransplantation
1986
FUNCTIONAL ASSESSMENT OF T CELL DEPLETION FROM BONE MARROW PRIOR TO THERAPEUTIC TRANSPLANTATION USING LIMITING DILUTION CULTURE METHODS
Rozans M, Smith B, Emerson S, Crimmins M, Laurent G, Reichert T, Burakoff S, Miller R. FUNCTIONAL ASSESSMENT OF T CELL DEPLETION FROM BONE MARROW PRIOR TO THERAPEUTIC TRANSPLANTATION USING LIMITING DILUTION CULTURE METHODS. Transplantation 1986, 42: 380-386. PMID: 3094209, DOI: 10.1097/00007890-198610000-00010.Peer-Reviewed Original ResearchConceptsT-cell depletionT cellsComplement-mediated depletionCell depletionFACS analysisIL-2Functional impairmentT-lymphocyte depletionT-cell contaminationBone marrow inoculumT cell setsComplement-mediated lysisDilution methodFlow cytometric methodLymphocyte depletionComplement treatmentMarrow inoculumCytotoxic effectorsInterleukin-2Functional assessmentT101 immunotoxinCulture methodCytometric methodCell contaminationEventual deathLong-lasting deficit of functional T cell precursors in human bone marrow transplant recipients revealed by limiting dilution methods.
Rozans MK, Smith BR, Burakoff SJ, Miller RA. Long-lasting deficit of functional T cell precursors in human bone marrow transplant recipients revealed by limiting dilution methods. The Journal Of Immunology 1986, 136: 4040-8. PMID: 2939139, DOI: 10.4049/jimmunol.136.11.4040.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBone Marrow TransplantationChildChild, PreschoolClone CellsFlow CytometryHematopoietic Stem CellsHumansImmunologic Deficiency SyndromesInfantInfant, NewbornInterleukin-2Leukocyte CountLymphocyte ActivationLymphocyte Culture Test, MixedTime FactorsT-LymphocytesT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerConceptsBone marrow transplantationBMT patientsHuman bone marrow transplant recipientsAllogeneic bone marrow transplantationBone marrow transplant recipientsNormal levelsResidual immune dysfunctionT cell frequenciesMarrow transplant recipientsDilution methodT cell precursorsNear-normal levelsTransplant recipientsBMT recipientsImmune dysfunctionMarrow transplantationPrecursor frequencyLeu-3Immune functionNormal controlsPatientsLeu-2Cell frequencyDecreased frequencyCell precursorsHTLV-III infection after bone marrow transplantation.
Antin JH, Smith BR, Ewenstein BM, Arceci RJ, Lipton JM, Page PL, Rappeport JM. HTLV-III infection after bone marrow transplantation. Blood 1986, 67: 160-3. PMID: 3000475, DOI: 10.1182/blood.v67.1.160.bloodjournal671160.Peer-Reviewed Original ResearchConceptsGraft-v-host diseaseHTLV-III infectionBone marrow transplantationHTLV-IIIMarrow transplantationChronic graft-v-host diseaseBone marrow transplant recipientsAcquisition of antibodiesChronic GVHD diseaseLate opportunistic infectionsLoss of immunocompetenceOnly risk factorMarrow transplant recipientsPeripheral blood lymphocytesTransfusion-associated AIDSGVHD diseaseLymphocyte phenotypingHost diseaseTransplant recipientsImmunodeficiency syndromeOpportunistic infectionsAsymptomatic individualsPatient's immunodeficiencyRisk factorsSevere immunodeficiency
1985
EFFICACY OF A CYCLOPHOSPHAMIDE-PROCARBAZINE-ANTITHYMOCYTE SERUM REGIMEN FOR PREVENTION OF GRAFT REJECTION FOLLOWING BONE MARROW TRANSPLANTATION FOR TRANSFUSED PATIENTS WITH APLASTIC ANEMIA
Smith BR, Guinan EC, Parkman R, Ferrara J, Levey RH, Nathan DG, Rappeport JM. EFFICACY OF A CYCLOPHOSPHAMIDE-PROCARBAZINE-ANTITHYMOCYTE SERUM REGIMEN FOR PREVENTION OF GRAFT REJECTION FOLLOWING BONE MARROW TRANSPLANTATION FOR TRANSFUSED PATIENTS WITH APLASTIC ANEMIA. Transplantation 1985, 39: 671-672. PMID: 3890295, DOI: 10.1097/00007890-198506000-00020.Peer-Reviewed Original Research
1983
Application of bone marrow transplantation in genetic diseases
Rappeport J, Smith B, Parkman R, Rosen F. Application of bone marrow transplantation in genetic diseases. Clinics In Haematology 1983, 12: 755-773. PMID: 6416728, DOI: 10.1016/s0308-2261(83)80009-5.Peer-Reviewed Original ResearchAgranulocytosisAnemia, AplasticAnimalsBone Marrow TransplantationCell SeparationChediak-Higashi SyndromeChildFemaleGenes, MHC Class IIGranulomatous Disease, ChronicHLA AntigensHumansImmunologic Deficiency SyndromesInfantMaleMiceMucopolysaccharidosesOsteopetrosisPhagocyte Bactericidal DysfunctionThalassemiaT-LymphocytesTransplantation, IsogeneicWiskott-Aldrich Syndrome