TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F0F1-ATP synthase and ubiquinone
Shertzer HG, Genter MB, Shen D, Nebert DW, Chen Y, Dalton TP. TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F0F1-ATP synthase and ubiquinone. Toxicology And Applied Pharmacology 2006, 217: 363-374. PMID: 17109908, PMCID: PMC1783833, DOI: 10.1016/j.taap.2006.09.014.Peer-Reviewed Original ResearchConceptsReactive oxygen productionATP levelsMitochondria generate ATPMitochondrial glutathione redox stateMitochondrial oxidative DNA damageF0F1-ATP synthaseATP/O ratioGlutathione redox stateOxygen productionATP synthaseGenerate ATPSignal transductionMitochondrial targetsOxidative DNA damageGreater respiratory rateOxidoreductase activityATP synthesisCell deathDNA damageFutile cycleRedox stateCellular pathologyRespiratory control ratioTCDD treatmentATP