Mechanistic considerations in 1,4-dioxane cancer risk assessment
Ginsberg G, Chen Y, Vasiliou V. Mechanistic considerations in 1,4-dioxane cancer risk assessment. Current Opinion In Environmental Science & Health 2022, 30: 100407. PMID: 37091947, PMCID: PMC10120849, DOI: 10.1016/j.coesh.2022.100407.Peer-Reviewed Original ResearchCarcinogenic effectsLinear low-dose extrapolationGenders of ratsDose responseInduction of CYP2E1Human liver cancerCancer risk assessmentLow-dose extrapolationLiver cancerLow doseAnimal studiesDose levelsChronic exposureLow human exposureDose extrapolationCarcinogenic responseStandard test batteryVivo genotoxicityRisk assessmentOxidative stressDisease-related processesOwn metabolismLess likelihoodMode of actionHuman exposure