2024
Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls
Díaz D, Tseng W, Michalska K. Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls. BMC Psychiatry 2024, 24: 1. PMID: 38167015, PMCID: PMC10759434, DOI: 10.1186/s12888-023-05403-6.Peer-Reviewed Original ResearchConceptsState anxietyTrait anxietyHappy facesEmotion processingLatina girlsImplicit emotion processingNon-anxious youthHigh trait anxietyFearful facial affectFearful facesEmotional valenceFacial affectNeural correlatesIndividual differencesBrain activationBrain responsesNeural activationReduced engagementCommunity sampleAnxietyInteractive effectsHigh levelsGirlsMethodsThe present studySystematic differences
2020
A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder
Ross AJ, Roule AL, Deveney CM, Towbin KE, Brotman MA, Leibenluft E, Tseng W. A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder. Bipolar Disorders 2020, 23: 263-273. PMID: 32790927, PMCID: PMC8074834, DOI: 10.1111/bdi.12985.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusFeedback processingBD youthNeural responsesReward-relevant stimuliFunctional activationSelf-reported frustrationSelf-reported affectAtypical activation patternsGoal-directed behaviorPrefrontal cortex connectivityBipolar disorderBipolar disorder youthAttentional abilitiesAttention taskImpaired attentionFMRI paradigmTask performanceFrontal gyrusAttention networkGreater recruitmentCortex connectivityGreater unhappinessIrritability symptomsInterest activation
2018
A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth
Kircanski K, White LK, Tseng WL, Wiggins JL, Frank HR, Sequeira S, Zhang S, Abend R, Towbin KE, Stringaris A, Pine DS, Leibenluft E, Brotman MA. A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 2018, 75: 631-639. PMID: 29625429, PMCID: PMC6137523, DOI: 10.1001/jamapsychiatry.2018.0468.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesCaudate NucleusCerebral CortexChildCross-Sectional StudiesFemaleFunctional NeuroimagingHumansIrritable MoodLatent Class AnalysisMagnetic Resonance ImagingMaleMood DisordersNeural PathwaysParietal LobePrefrontal CortexConceptsParent-reported irritabilityNeural mechanismsAnxiety symptomsLatent variable approachPediatric irritabilityNeural correlatesAmygdala connectivityShared varianceCross-sectional functional magnetic resonance imaging studyNeural activityFunctional magnetic resonance imaging studyDot-probe taskAffective Reactivity IndexVentrolateral prefrontal cortexCommon neural mechanismsAmygdala functional connectivityFunctional magnetic resonanceLevels of irritabilityWhole-brain analysisInferior parietal lobuleData-driven phenotypingMultiple diagnostic categoriesCo-occurring symptomsMagnetic resonance imaging studyNeutral faces
2017
Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology
Stoddard J, Tseng WL, Kim P, Chen G, Yi J, Donahue L, Brotman MA, Towbin KE, Pine DS, Leibenluft E. Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology. JAMA Psychiatry 2017, 74: 95-103. PMID: 27902832, PMCID: PMC6309540, DOI: 10.1001/jamapsychiatry.2016.3282.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxiety DisordersArousalAttention Deficit Disorder with HyperactivityBrainChildCross-Sectional StudiesDominance, CerebralEmotionsFacial RecognitionFemaleHumansIrritable MoodMagnetic Resonance ImagingMaleMental DisordersMood DisordersNerve NetPrefrontal CortexPsychopathologyConceptsFunctional magnetic resonance imagingPrefrontal cortex connectivityFace emotionsNeural responsesCortex connectivityMedial prefrontal cortex connectivityAttention-deficit/hyperactivity disorderChild Anxiety Related DisordersThreat-related facesDisruptive Mood DysregulationPathophysiology of irritabilityFace emotion processingAmygdala-medial prefrontal cortex connectivityCross-sectional functional magnetic resonanceAffective Reactivity IndexBrain-behavior relationshipsVentral visual areasAssociations of irritabilityUnique effectsAmygdala functional connectivityAnxiety Related DisordersFunctional magnetic resonanceYouth ages 8Angry facesFearful faces
2016
Functional connectivity during masked and unmasked face emotion processing in bipolar disorder
Tseng WL, Thomas LA, Harkins E, Stoddard J, Zarate CA, Pine DS, Leibenluft E, Brotman MA. Functional connectivity during masked and unmasked face emotion processing in bipolar disorder. Psychiatry Research Neuroimaging 2016, 258: 1-9. PMID: 27814457, PMCID: PMC5135603, DOI: 10.1016/j.pscychresns.2016.10.006.Peer-Reviewed Original ResearchConceptsFace emotion processingEmotion processingHealthy volunteersBipolar disorderFunctional connectivityAffective priming taskAmygdala-vmPFC connectivityVentromedial prefrontal cortexExpression of emotionsBD patientsMedial frontal gyrusNeutral facesPriming taskEmotion typeEmotional processingFMRI scanningActivation differencesFrontal gyrusGreater activationLess activationPrefrontal cortexConnectivity findingsNeural connectivityPathophysiological correlatesNeural dysfunction
2013
Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands
Brotman MA, Tseng WL, Olsavsky AK, Fromm SJ, Muhrer EJ, Rutenberg JG, Deveney CM, Adleman NE, Zarate CA, Pine DS, Leibenluft E. Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands. Psychological Medicine 2013, 44: 1639-1651. PMID: 23930595, PMCID: PMC3922892, DOI: 10.1017/s003329171300202x.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexFunctional magnetic resonance imagingNeutral facesInferior frontal gyrusTask demandsImplicit processingHappy facesPassive viewingAmygdala hyperactivationCognitive control circuitsFace emotion processingBipolar disorderPediatric bipolar disorderHealthy comparison subjectsExplicit processingFamily-wise errorFearful facesAttentional conditionsFace emotionsAttentional demandsEmotion processingFrontal gyrusCingulate cortexHypoactivationComparison subjects