2023
Autistic Symptoms, Irritability, and Executive Dysfunctions: Symptom Dynamics from Multi-Network Models
Lee K, Gau S, Tseng W. Autistic Symptoms, Irritability, and Executive Dysfunctions: Symptom Dynamics from Multi-Network Models. Journal Of Autism And Developmental Disorders 2023, 54: 3078-3093. PMID: 37453959, DOI: 10.1007/s10803-023-05981-0.Peer-Reviewed Original ResearchAutism spectrum disorderIrritability symptomsExecutive functionExecutive dysfunctionAutistic symptomsCognitive-behavioral mechanismsSocial communication difficultiesRelative importance networksSample of childrenNeurotypical peersElevated irritabilityASD diagnosisSpectrum disorderBridge symptomsCommunication difficultiesTemper outburstsPredictive pathSymptom dynamicsUnaffected siblingsPartial correlationMoodEntire sampleIrritabilitySpecific relationSymptom nodesAssociations between sleep quality and irritability: Testing the mediating role of emotion regulation
Whiting C, Bellaert N, Deveney C, Tseng W. Associations between sleep quality and irritability: Testing the mediating role of emotion regulation. Personality And Individual Differences 2023, 213: 112322. PMID: 38549685, PMCID: PMC10978035, DOI: 10.1016/j.paid.2023.112322.Peer-Reviewed Original ResearchSleep qualityEmotion regulationPoor sleep qualityMental health disordersMental health difficultiesCommon symptomsPoor sleepPossible intervention targetsSleep problemsHealth disordersDepression symptomsClinical implicationsIrritabilityHealth difficultiesRange of internalizingSelf-report measuresSleepSymptomsIntervention targetsPotential mediatorsConfirmatory factor analysisHigh irritabilityAssociationDirect associationPresent study
2022
Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability
Linke J, Haller S, Xu E, Nguyen L, Chue A, Botz-Zapp C, Revzina O, Perlstein S, Ross A, Tseng W, Shaw P, Brotman M, Pine D, Gotts S, Leibenluft E, Kircanski K. Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 684-695. PMID: 36563874, PMCID: PMC11224120, DOI: 10.1016/j.jaac.2022.11.009.Peer-Reviewed Original ResearchConceptsResting-state scansPathophysiology of irritabilitySelf-reported irritabilityFunctional magnetic resonance imagingMagnetic resonance imagingParent-reported irritabilitySpecific intervention targetsRisk factorsMotor functionPsychiatric consultationCircuit reorganizationCommon reasonAffective disordersBrain network configurationIrritability symptomsResonance imagingBrain regionsIrritabilityCentral mechanismsAberrant responsesPilot studyIntervention targetsRecovery periodPediatric irritabilityBrain networks
2021
Perinatal and birth correlates of childhood irritability in Taiwan's national epidemiological study
Lee KS, Xiao J, Liew Z, Gau SS, Tseng WL. Perinatal and birth correlates of childhood irritability in Taiwan's national epidemiological study. Journal Of Affective Disorders 2021, 299: 273-280. PMID: 34906640, PMCID: PMC8767526, DOI: 10.1016/j.jad.2021.12.016.Peer-Reviewed Original ResearchConceptsNational epidemiological studyBirth characteristicsEpidemiological studiesChildhood irritabilityEarly life exposureAdverse mental healthBirth correlatesPerinatal perspectiveVaginal bleedingMaternal smokingAffective Reactivity IndexPerinatal risksBirth factorsLife exposureProspective assessmentIrritabilityTemper outburstsRecall biasLife outcomesPerinatalMental healthEarly etiologyChild irritabilityRetrospective assessmentEnvironmental exposures
2020
Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability
Tseng WL. Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: 1327-1329. PMID: 32966839, PMCID: PMC8143431, DOI: 10.1016/j.jaac.2020.09.008.Peer-Reviewed Original ResearchConceptsDisruptive mood dysregulation disorderAttention-deficit/hyperactivity disorderOppositional defiant disorderLong-term impairmentDSM-5 categoriesPediatric disordersHigh suicidalityAnxiety disordersHyperactivity disorderDisordersIrritabilityDefiant disorderHallmark featurePediatric irritabilityTransdiagnostic symptomsNeural mechanismsTransdiagnostic approachAutism spectrum disorderChild psychiatrySpectrum disorder
2017
Test-retest reliability and validity of a frustration paradigm and irritability measures
Tseng WL, Moroney E, Machlin L, Roberson-Nay R, Hettema JM, Carney D, Stoddard J, Towbin KA, Pine DS, Leibenluft E, Brotman MA. Test-retest reliability and validity of a frustration paradigm and irritability measures. Journal Of Affective Disorders 2017, 212: 38-45. PMID: 28135689, PMCID: PMC8049456, DOI: 10.1016/j.jad.2017.01.024.Peer-Reviewed Original ResearchConceptsTest-retest reliabilityParent-reported irritabilityIrritability measuresGood test-retest reliabilityNegative affectIrritability ScaleValidity of assessmentsBehavioral paradigmsChild irritabilityTreatment researchGeneral population sampleConvergent validityExcellent test-retest reliabilityModest supportConstruct validityTaskParticipantsIrritabilityParadigmIntraclass correlation