2014
Litigation Seeking Access to Data From Ongoing Clinical Trials: A Threat to Clinical Research
Kernan WN, Viscoli CM, Varughese MC. Litigation Seeking Access to Data From Ongoing Clinical Trials: A Threat to Clinical Research. JAMA Internal Medicine 2014, 174: 1502-1504. PMID: 25047222, PMCID: PMC5758866, DOI: 10.1001/jamainternmed.2014.3248.Peer-Reviewed Original Research
2013
Adherence reporting in randomized controlled trials
Zhang Z, Peluso MJ, Gross CP, Viscoli CM, Kernan WN. Adherence reporting in randomized controlled trials. Clinical Trials 2013, 11: 195-204. PMID: 24357665, DOI: 10.1177/1740774513512565.Peer-Reviewed Original ResearchConceptsAdherence monitoringGeneral medicineStudy drug adherenceReporting of adherenceImportance of adherenceReporting Trials (CONSORT) statementRank correlation coefficientStudy medicationOral pharmacotherapyStudy drugMedian adherencePharmacologic interventionsTreatment acceptanceTreatment adherenceTrials statementTrial characteristicsAdherence reportingLow adherenceStudy qualityTherapeutic effectChi-square analysisConsolidated StandardsRCT manuscriptsAdherence informationAdherence measurementUse of Recruitment Networks in Randomized Trials
Kernan WN. Use of Recruitment Networks in Randomized Trials. Stroke 2013, 44: s119-s121. PMID: 23709705, DOI: 10.1161/strokeaha.111.000694.Peer-Reviewed Original Research
2005
Altruism as a reason for participation in clinical trials was independently associated with adherence
Rosenbaum JR, Wells CK, Viscoli CM, Brass LM, Kernan WN, Horwitz RI. Altruism as a reason for participation in clinical trials was independently associated with adherence. Journal Of Clinical Epidemiology 2005, 58: 1109-1114. PMID: 16223653, DOI: 10.1016/j.jclinepi.2005.03.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedAltruismEstrogensFemaleHumansLogistic ModelsMiddle AgedPatient CompliancePatient ParticipationRandomized Controlled Trials as TopicStrokeConceptsClinical trialsBetter functional statusStudy medicationMedical regimenRecruitment of participantsClinical featuresStroke trialsFunctional statusWomen's EstrogenStratified analysisMultivariable regressionClinical researchEstrogenTrialsAdherenceBaseline featuresSocial supportFurther investigationWomenParticipantsAltruistic reasonsPossible contributionHigh levelsPlaceboMedications
2003
Re: Evaluation of acute candesartan cilexetil therapy in stroke survivors.
Kernan WN. Re: Evaluation of acute candesartan cilexetil therapy in stroke survivors. Stroke 2003, 34: e237-8; author reply e237-8. PMID: 14631078, DOI: 10.1161/01.str.0000104158.59498.bc.Peer-Reviewed Original ResearchBenzimidazolesBiasBiphenyl CompoundsBlood PressureDouble-Blind MethodHumansRandomized Controlled Trials as TopicResearch DesignStrokeSurvivorsTetrazolesInfluence of race, clinical, and other socio-demographic features on trial participation
Corbie-Smith G, Viscoli CM, Kernan WN, Brass LM, Sarrel P, Horwitz RI. Influence of race, clinical, and other socio-demographic features on trial participation. Journal Of Clinical Epidemiology 2003, 56: 304-309. PMID: 12767406, DOI: 10.1016/s0895-4356(03)00046-5.Peer-Reviewed Original ResearchConceptsTrial participationPrevious estrogen useClinical trial participationHistory of hysterectomyEstrogen useClinical characteristicsStroke trialsWomen's EstrogenClinical trialsConsent ratesCognitive impairmentSocio-demographic featuresMultivariate modelInfluence of raceHysterectomyEstrogenWomen's decisionsTrialsEthnic groupsImpairmentVisitsWomen
2002
Clinical assessment of function among women with a recent cerebrovascular event: a self-reported versus performance-based measure.
Owens PL, Bradley EH, Horwitz SM, Viscoli CM, Kernan WN, Brass LM, Sarrel PM, Horwitz RI. Clinical assessment of function among women with a recent cerebrovascular event: a self-reported versus performance-based measure. Annals Of Internal Medicine 2002, 136: 802-11. PMID: 12044128, DOI: 10.7326/0003-4819-136-11-200206040-00008.Peer-Reviewed Original ResearchConceptsLong-term health outcomesRecent cerebrovascular eventsLevel of functionCerebrovascular eventsPerformance-based measuresHealth outcomesSelf-reported functional statusTransient ischemic attackProspective cohort studyPhysical performance testsSelf-report measuresIschemic attackPostmenopausal womenBarthel IndexCohort studyNonwhite ethnicityFunctional statusClinical assessmentMost womenHealth measuresClinical settingSubsequent strokeWomenOutcomesStroke
1999
Stratified Randomization for Clinical Trials
Kernan W, Viscoli C, Makuch R, Brass L, Horwitz R. Stratified Randomization for Clinical Trials. Journal Of Clinical Epidemiology 1999, 52: 19-26. PMID: 9973070, DOI: 10.1016/s0895-4356(98)00138-3.Peer-Reviewed Original ResearchMeSH KeywordsBiasData Interpretation, StatisticalEffect Modifier, EpidemiologicGuidelines as TopicHumansPrognosisRandom AllocationRandomized Controlled Trials as TopicReproducibility of ResultsResearch DesignTreatment OutcomeConceptsStratified randomizationSmall trialsInterim analysisActive-control equivalence trialsClinical factorsLarge trialsSuperiority trialSubgroup analysisClinical trialsTreatment responsivenessTreatment outcomesMEDLINE searchTreatment groupsStratification factorsEquivalence trialPrognosisTrialsRandomizationType ITheoretical benefitsImportance of stratificationStratificationSample sizeInvestigatorsPatients
1991
A methodological appraisal of research on prognosis after transient ischemic attacks.
Kernan W, Feinstein A, Brass L. A methodological appraisal of research on prognosis after transient ischemic attacks. Stroke 1991, 22: 1108-1116. PMID: 1926253, DOI: 10.1161/01.str.22.9.1108.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesHumansIschemic Attack, TransientMultivariate AnalysisPrognosisRandomized Controlled Trials as TopicResearchResearch DesignRisk FactorsConceptsTransient ischemic attackTransient ischemiaIschemic attackEligible studiesAspects of prognosisObservational cohort studyPrognosis of patientsSubgroup of patientsAppropriate end pointsPeer-reviewed journalsCohort studyInception cohortOutcome ratesIndividual patientsDiagnostic criteriaPatientsOutcome riskIschemiaMultivariate analysisPrognosisEnd pointSubsequent strokeAdherencePredictive variablesStroke