2001
A Quality-of-Life Instrument for Young Hemorrhagic Stroke Patients
Hamedani A, Wells C, Brass L, Kernan W, Viscoli C, Maraire J, Awad I, Horwitz R. A Quality-of-Life Instrument for Young Hemorrhagic Stroke Patients. Stroke 2001, 32: 687-695. PMID: 11239188, DOI: 10.1161/01.str.32.3.687.Peer-Reviewed Original ResearchConceptsOutcome measuresHemorrhagic strokeQuality of lifeValid QOL instrumentHemorrhagic stroke patientsHemorrhagic stroke survivorsAvailable outcome measuresDistinct subject groupsYounger patientsStroke patientsPatient interviewsNeurological impairmentStroke survivorsMotor functionQOL instrumentsLife instrumentsMortality ratePatient's lifeHigh initial mortality rateStrokePatientsCeiling effectsSubject groupsInitial mortality rateInternal consistency
1999
Stratified Randomization for Clinical Trials
Kernan W, Viscoli C, Makuch R, Brass L, Horwitz R. Stratified Randomization for Clinical Trials. Journal Of Clinical Epidemiology 1999, 52: 19-26. PMID: 9973070, DOI: 10.1016/s0895-4356(98)00138-3.Peer-Reviewed Original ResearchConceptsStratified randomizationSmall trialsInterim analysisActive-control equivalence trialsClinical factorsLarge trialsSuperiority trialSubgroup analysisClinical trialsTreatment responsivenessTreatment outcomesMEDLINE searchTreatment groupsStratification factorsEquivalence trialPrognosisTrialsRandomizationType ITheoretical benefitsImportance of stratificationStratificationSample sizeInvestigatorsPatients