2020
Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers
Ogden A, Bhattarai S, Sahoo B, Mongan N, Alsaleem M, Green A, Aleskandarany M, Ellis I, Pattni S, Li X, Moreno C, Krishnamurti U, Janssen E, Jonsdottir K, Rakha E, Rida P, Aneja R. Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers. Scientific Reports 2020, 10: 3009. PMID: 32080212, PMCID: PMC7033213, DOI: 10.1038/s41598-020-59514-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic AgentsBiomarkers, TumorCohort StudiesErbB ReceptorsFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMammary Glands, HumanMiddle AgedNeoplasm StagingNF-kappa BPoly (ADP-Ribose) Polymerase-1PrognosisReceptor, ErbB-3Survival AnalysisThioredoxinsTriple Negative Breast NeoplasmsTumor Suppressor Protein p53
2011
Correlation of Immunohistochemical Expression of p53 With Unamplified Chromosome 17 Polysomy in Invasive Breast Carcinoma
Krishnamurti U, Zarineh A, Atem F, Silverman J. Correlation of Immunohistochemical Expression of p53 With Unamplified Chromosome 17 Polysomy in Invasive Breast Carcinoma. Applied Immunohistochemistry & Molecular Morphology 2011, 19: 28-32. PMID: 20823770, DOI: 10.1097/pai.0b013e3181e9bb6f.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyBreast NeoplasmsChromosomes, Human, Pair 17FemaleGene AmplificationGene Expression Regulation, NeoplasticHumansImmunohistochemistryNeoplasm InvasivenessReceptor, ErbB-2Receptors, EstrogenTumor Suppressor Protein p53ConceptsInvasive breast carcinomaChromosome 17 polysomyBreast carcinomaHER2 amplificationReceptor negativityPrognostic indicatorNottingham scoreBreast cancerNeck squamous cell carcinomaNonsmall cell lung carcinomaHormone receptor negativityAdverse prognostic indicatorEstrogen receptor negativitySquamous cell carcinomaIndependent prognostic indicatorCell lung carcinomaCell carcinomaP53 positivityBladder carcinomaP53 immunostainingP53 overexpressionImmunohistochemical expressionLung carcinomaCarcinomaP53 expression
2007
Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations?
Krishnamurti U, Sasatomi E, Swalsky P, Finkelstein S, Ohori N. Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations? Archives Of Pathology & Laboratory Medicine 2007, 131: 74-80. PMID: 17227126, DOI: 10.5858/2007-131-74-aolohi.Peer-Reviewed Original ResearchConceptsK-ras mutationsBile duct brushingsLoss of heterozygosityMalignant outcomeFractional allelic lossDuct brushingsCytology casesAllelic lossMolecular alterationsBile duct brushing cytologyPilot studyConventional cytologic evaluationSurgical pathology specimenCorresponding surgical specimensDuct brushing cytologySurgical pathology specimensDetection of malignancySubtle molecular alterationsSurgical outcomesSurgical specimenPathology specimenCytologic findingsSurgical specimensBrushing cytologyCytologic evaluation