Differential Patterns of Delayed Emotion Circuit Maturation in Abused Girls With and Without Internalizing Psychopathology
Keding T, Heyn S, Russell J, Zhu X, Cisler J, McLaughlin K, Herringa R. Differential Patterns of Delayed Emotion Circuit Maturation in Abused Girls With and Without Internalizing Psychopathology. American Journal Of Psychiatry 2021, 178: 1026-1036. PMID: 34407623, PMCID: PMC8570983, DOI: 10.1176/appi.ajp.2021.20081192.Peer-Reviewed Original ResearchConceptsChildhood abusePhysical neglectBrain Age Gap EstimationNormative brain developmentCircuit maturationBrain-wide patternsChildhood physical neglectEarly life adversityFronto-parietal cortexEmotion circuitsThreat generalizationGray matter volumePresence of psychopathologyResilient girlsLateral prefrontalHyperarousal symptomsInternalizing psychopathologyNeural contributorsAbused girlsInternalizing disorder diagnosesInternalizing diagnosesMaltreatment historyAbuse exposureAbuse historyNeurodevelopmental markersChildhood exposure to interpersonal violence is associated with greater transdiagnostic integration of psychiatric symptoms
Russell JD, Keding TJ, He Q, Li JJ, Herringa RJ. Childhood exposure to interpersonal violence is associated with greater transdiagnostic integration of psychiatric symptoms. Psychological Medicine 2020, 52: 1883-1891. PMID: 33161911, PMCID: PMC8106688, DOI: 10.1017/s0033291720003712.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxiety DisordersChildExposure to ViolenceHumansMental DisordersMental HealthViolenceConceptsChildhood exposureIPV exposureTreatment-resistant populationStructured Clinical InterviewGreater psychiatric comorbidityMental health symptomsPotential clinical implicationsInterpersonal violencePopulation-representative sampleBridge symptomsPsychiatric comorbidityViolence-exposed youthPsychiatric symptomsTreatment resistanceSymptom communitiesClinical InterviewHealth symptomsMental illnessClinical implicationsSymptomsSymptom associationMultiple disordersViolence exposureDiagnostic statusPatterns of association