Featured Publications
Differential Patterns of Delayed Emotion Circuit Maturation in Abused Girls With and Without Internalizing Psychopathology
Keding T, Heyn S, Russell J, Zhu X, Cisler J, McLaughlin K, Herringa R. Differential Patterns of Delayed Emotion Circuit Maturation in Abused Girls With and Without Internalizing Psychopathology. American Journal Of Psychiatry 2021, 178: 1026-1036. PMID: 34407623, PMCID: PMC8570983, DOI: 10.1176/appi.ajp.2021.20081192.Peer-Reviewed Original ResearchConceptsChildhood abusePhysical neglectBrain Age Gap EstimationNormative brain developmentCircuit maturationBrain-wide patternsChildhood physical neglectEarly life adversityFronto-parietal cortexEmotion circuitsThreat generalizationGray matter volumePresence of psychopathologyResilient girlsLateral prefrontalHyperarousal symptomsInternalizing psychopathologyNeural contributorsAbused girlsInternalizing disorder diagnosesInternalizing diagnosesMaltreatment historyAbuse exposureAbuse historyNeurodevelopmental markers
2018
Abnormal Prefrontal Development in Pediatric Posttraumatic Stress Disorder: A Longitudinal Structural and Functional Magnetic Resonance Imaging Study
Heyn SA, Keding TJ, Ross MC, Cisler JM, Mumford JA, Herringa RJ. Abnormal Prefrontal Development in Pediatric Posttraumatic Stress Disorder: A Longitudinal Structural and Functional Magnetic Resonance Imaging Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 4: 171-179. PMID: 30343133, PMCID: PMC6371792, DOI: 10.1016/j.bpsc.2018.07.013.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderPediatric PTSDGray matter volumeVentrolateral prefrontal cortexVentromedial prefrontal cortexPosttraumatic stress disorderPrefrontal cortexStress disorderFunctional magnetic resonance imaging studyBilateral ventrolateral prefrontal cortexRight ventromedial prefrontal cortexFunctional magnetic resonance imagingSelf-referential processingIntrinsic connectivity analysesDorsolateral prefrontal cortexResting-state functional magnetic resonance imagingPrefrontal gray matter volumeWhole-brain structural analysisFunctional brain abnormalitiesMagnetic resonance imaging studyResonance imaging studyGray matter developmentPrefrontal developmentNormative decreaseStructural magnetic resonance
2016
Paradoxical Prefrontal–Amygdala Recruitment to Angry and Happy Expressions in Pediatric Posttraumatic Stress Disorder
Keding TJ, Herringa RJ. Paradoxical Prefrontal–Amygdala Recruitment to Angry and Happy Expressions in Pediatric Posttraumatic Stress Disorder. Neuropsychopharmacology 2016, 41: 2903-2912. PMID: 27329685, PMCID: PMC5061882, DOI: 10.1038/npp.2016.104.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderPediatric PTSDPosttraumatic stress disorderAngry facesPTSD youthHappy facesMedial prefrontal cortexHealthy youthEmotional facesEmotional expressionStress disorderCross-sectional age-related differencesImplicit emotional faceThreat-related emotionsPositive emotional expressionEmotion processing circuitryTrauma-related psychopathologyEmotional faces taskAbnormal neural responsesPrefrontal-amygdala circuitsWhole-brain analysisAmygdala/hippocampusAge-related differencesAge-related findingsEmotion interactionDefault-Mode Network Abnormalities in Pediatric Posttraumatic Stress Disorder
Patriat R, Birn RM, Keding TJ, Herringa RJ. Default-Mode Network Abnormalities in Pediatric Posttraumatic Stress Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 319-327. PMID: 27015723, PMCID: PMC4808564, DOI: 10.1016/j.jaac.2016.01.010.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderPosttraumatic stress disorderTask-positive networkAttentional control networkRe-experiencing symptomsDefault mode network abnormalitiesGreater anticorrelationStress disorderDMN connectivityAdult posttraumatic stress disorderFunctional magnetic resonance imaging studyLarge-scale network abnormalitiesTrauma-related thoughtsNetwork abnormalitiesControl networkResting-state functional magnetic resonance imaging studyPrefrontal cortex connectivityIndependent component analysisSeed-based connectivityMagnetic resonance imaging studyAutobiographical memoryResonance imaging studyCortex connectivityHealthy youthNeurodevelopmental factors
2014
Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder
Keding TJ, Herringa RJ. Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder. Neuropsychopharmacology 2014, 40: 537-545. PMID: 25212487, PMCID: PMC4289962, DOI: 10.1038/npp.2014.239.Peer-Reviewed Original ResearchConceptsGray matter volumeHippocampal volumeAge-related differencesPediatric PTSDHealthy youthPediatric post-traumatic stress disorderPTSD youthPrefrontal cortexStructural brain studiesSubgenual anterior cingulate cortexAge-dependent effectsAmygdala/hippocampusPost-traumatic stress disorderAnatomical brain MRIAnterior cingulate cortexRight anterior hippocampusMedial prefrontal cortexAbnormal structureHigh-resolution MRIPTSD durationCross-sectional designOverall group differencesNeurotoxic processesRe-experiencing symptomsBrain MRI