Featured Publications
Violence Exposure and Amygdala-Prefrontal Circuit Maturation: Developmental Markers of Psychiatric Risk in Youth
Keding T, Herringa R. Violence Exposure and Amygdala-Prefrontal Circuit Maturation: Developmental Markers of Psychiatric Risk in Youth. Biological Psychiatry 2022, 91: s47-s48. DOI: 10.1016/j.biopsych.2022.02.140.Peer-Reviewed Original ResearchChildhood exposure to interpersonal violence is associated with greater transdiagnostic integration of psychiatric symptoms
Russell JD, Keding TJ, He Q, Li JJ, Herringa RJ. Childhood exposure to interpersonal violence is associated with greater transdiagnostic integration of psychiatric symptoms. Psychological Medicine 2020, 52: 1883-1891. PMID: 33161911, PMCID: PMC8106688, DOI: 10.1017/s0033291720003712.Peer-Reviewed Original ResearchConceptsChildhood exposureIPV exposureTreatment-resistant populationStructured Clinical InterviewGreater psychiatric comorbidityMental health symptomsPotential clinical implicationsInterpersonal violencePopulation-representative sampleBridge symptomsPsychiatric comorbidityViolence-exposed youthPsychiatric symptomsTreatment resistanceSymptom communitiesClinical InterviewHealth symptomsMental illnessClinical implicationsSymptomsSymptom associationMultiple disordersViolence exposureDiagnostic statusPatterns of association
2024
Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation during Childhood and Adolescence
Keding T, Russell J, Zhu X, He Q, Li J, Herringa R. Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation during Childhood and Adolescence. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39182725, DOI: 10.1016/j.bpsc.2024.08.003.Peer-Reviewed Original ResearchBasolateral amygdalaFunctional connectivityPsychiatric symptomsViolence exposureCircuit maturationOrbitofrontal cortex functional connectivityDevelopment of psychiatric symptomsResting-state functional connectivityEffects of violence exposureAmygdala-prefrontal cortexSeverity of psychopathologyBrain age gap estimationIncreased psychiatric symptomsPhiladelphia Neurodevelopmental CohortThreat appraisal processEffects of adversityExposure to violenceNeurobiological correlatesAssociated with delayed maturationBrain circuitryNeurodevelopmental mechanismsPsychiatric riskIndividual differencesNeurodevelopmental CohortAtypical neurodevelopment