2023
Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort
He Q, Keding T, Zhang Q, Miao J, Russell J, Herringa R, Lu Q, Travers B, Li J. Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort. Journal Of Neurodevelopmental Disorders 2023, 15: 30. PMID: 37653373, PMCID: PMC10469494, DOI: 10.1186/s11689-023-09498-6.Peer-Reviewed Original ResearchConceptsADHD polygenic scoresDorsolateral prefrontal cortexADHD outcomesPolygenic scoresIA symptomsHyperactivity-impulsivity symptomsMultiple mediation modelIndirect effectsPhiladelphia Neurodevelopmental CohortBrain volumeInferior temporal lobeBrain-based biomarkersADHD inattentionGray matter volumeADHD symptomsHI symptomsMediation modelAngular gyrusNeurobiological mechanismsNeurodevelopmental CohortADHDPrefrontal cortexInattentionTemporal lobeBrain regions
2018
Abnormal Prefrontal Development in Pediatric Posttraumatic Stress Disorder: A Longitudinal Structural and Functional Magnetic Resonance Imaging Study
Heyn SA, Keding TJ, Ross MC, Cisler JM, Mumford JA, Herringa RJ. Abnormal Prefrontal Development in Pediatric Posttraumatic Stress Disorder: A Longitudinal Structural and Functional Magnetic Resonance Imaging Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 4: 171-179. PMID: 30343133, PMCID: PMC6371792, DOI: 10.1016/j.bpsc.2018.07.013.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderPediatric PTSDGray matter volumeVentrolateral prefrontal cortexVentromedial prefrontal cortexPosttraumatic stress disorderPrefrontal cortexStress disorderFunctional magnetic resonance imaging studyBilateral ventrolateral prefrontal cortexRight ventromedial prefrontal cortexFunctional magnetic resonance imagingSelf-referential processingIntrinsic connectivity analysesDorsolateral prefrontal cortexResting-state functional magnetic resonance imagingPrefrontal gray matter volumeWhole-brain structural analysisFunctional brain abnormalitiesMagnetic resonance imaging studyResonance imaging studyGray matter developmentPrefrontal developmentNormative decreaseStructural magnetic resonance
2014
Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder
Keding TJ, Herringa RJ. Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder. Neuropsychopharmacology 2014, 40: 537-545. PMID: 25212487, PMCID: PMC4289962, DOI: 10.1038/npp.2014.239.Peer-Reviewed Original ResearchConceptsGray matter volumeHippocampal volumeAge-related differencesPediatric PTSDHealthy youthPediatric post-traumatic stress disorderPTSD youthPrefrontal cortexStructural brain studiesSubgenual anterior cingulate cortexAge-dependent effectsAmygdala/hippocampusPost-traumatic stress disorderAnatomical brain MRIAnterior cingulate cortexRight anterior hippocampusMedial prefrontal cortexAbnormal structureHigh-resolution MRIPTSD durationCross-sectional designOverall group differencesNeurotoxic processesRe-experiencing symptomsBrain MRI