2022
Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus
Hehnly C, Ssentongo P, Bebell L, Burgoine K, Bazira J, Fronterre C, Kumbakumba E, Mulondo R, Mbabazi-Kabachelor E, Morton S, Ngonzi J, Ochora M, Olupot-Olupot P, Mugamba J, Onen J, Roberts D, Sheldon K, Sinnar S, Smith J, Ssenyonga P, Kiwanuka J, Paulson J, Meier F, Ericson J, Broach J, Schiff S. Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus. International Journal Of Infectious Diseases 2022, 118: 24-33. PMID: 35150915, PMCID: PMC9058984, DOI: 10.1016/j.ijid.2022.02.005.Peer-Reviewed Original ResearchConceptsNewborn-mother pairsCMV prevalenceClinical sepsisCytomegalovirus infectionCerebrospinal fluidPrevalence of CMVQuantitative PCRCMV positivityPostinfectious hydrocephalusVaginal sheddingCMV infectionHIV seropositivityNeonatal ageMaternal ageMaternal vaginalRisk factorsMedical CenterLong-term consequencesMother pairsSepsisNeonatesInfantsPrevalenceHydrocephalusCMV
2020
The Problem of Microbial Dark Matter in Neonatal Sepsis - Volume 26, Number 11—November 2020 - Emerging Infectious Diseases journal - CDC
Sinnar S, Schiff S. The Problem of Microbial Dark Matter in Neonatal Sepsis - Volume 26, Number 11—November 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 2543-2548. PMID: 33080169, PMCID: PMC7588532, DOI: 10.3201/eid2611.200004.Peer-Reviewed Original ResearchConceptsNeonatal sepsisCausative pathogenInfectious Diseases journal - CDCCulture recovery ratesAntimicrobial therapyBlood culturesTimely diagnosisAntimicrobial stewardshipWorldwide deathsMost blood culturesUnidentified pathogensTransmission patternsDeathPathogen discoveryWhole metagenomic sequencingPathogensEffective diagnosticsMetagenomic sequencingSepsisPatientsInfantsTherapyDiagnosisRecovery ratePaenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants
Paulson J, Williams B, Hehnly C, Mishra N, Sinnar S, Zhang L, Ssentongo P, Mbabazi-Kabachelor E, Wijetunge D, von Bredow B, Mulondo R, Kiwanuka J, Bajunirwe F, Bazira J, Bebell L, Burgoine K, Couto-Rodriguez M, Ericson J, Erickson T, Ferrari M, Gladstone M, Guo C, Haran M, Hornig M, Isaacs A, Kaaya B, Kangere S, Kulkarni A, Kumbakumba E, Li X, Limbrick D, Magombe J, Morton S, Mugamba J, Ng J, Olupot-Olupot P, Onen J, Peterson M, Roy F, Sheldon K, Townsend R, Weeks A, Whalen A, Quackenbush J, Ssenyonga P, Galperin M, Almeida M, Atkins H, Warf B, Lipkin W, Broach J, Schiff S. Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants. Science Translational Medicine 2020, 12 PMID: 32998967, PMCID: PMC7774825, DOI: 10.1126/scitranslmed.aba0565.Peer-Reviewed Original ResearchConceptsPostinfectious hydrocephalusCSF samplesPIH casesPotential causative organismsCerebrospinal fluid accumulationCytomegalovirus coinfectionUgandan infantsNeonatal sepsisSurgical palliationNeonatal infectionInfant casesOptimal treatmentInfant cohortCommon causeCausative organismPediatric hydrocephalusFluid accumulationHydrocephalusAnaerobic bacterial isolatesControl casesInfectionFacultative anaerobic bacterial isolatesInfantsParasitic DNADiseaseAssociation of Undernutrition and Neonatal, Infant and Under-5 Mortality: Evidence from 62 Low-Income and Middle-Income Countries
Ssentongo P, Lewcun J, Ssentongo A, Ba D, Fronterre C, Ericson J, Gernand A, Wang M, Du P, Chinchilli V, Schiff S. Association of Undernutrition and Neonatal, Infant and Under-5 Mortality: Evidence from 62 Low-Income and Middle-Income Countries. Current Developments In Nutrition 2020, 4: nzaa053_116. PMCID: PMC7258382, DOI: 10.1093/cdn/nzaa053_116.Peer-Reviewed Original ResearchNeonatal mortalityRelative riskMiddle-income countriesChild mortalityInfant mortalityRepresentative cross-sectional surveyAssociation of undernutritionMultivariate Poisson regression modelEarly childhood undernutritionCross-sectional surveyUnder-5 MortalityPoisson regression modelsMean durationLive birthsMortality incidenceMillennium Development Goals eraMortality rateResults OverallMDG 4Country-level prevalenceChildhood undernutritionInfantsMortalityBreastfeedingNational InstituteComplete Genome Sequences of the Human Pathogen Paenibacillus thiaminolyticus Mbale and Type Strain P. thiaminolyticus NRRL B-4156
Hehnly C, Zhang L, Paulson J, Almeida M, von Bredow B, Wijetunge D, Galperin M, Sheldon K, Schiff S, Broach J. Complete Genome Sequences of the Human Pathogen Paenibacillus thiaminolyticus Mbale and Type Strain P. thiaminolyticus NRRL B-4156. Microbiology Resource Announcements 2020, 9: 10.1128/mra.00181-20. PMID: 32273361, PMCID: PMC7380522, DOI: 10.1128/mra.00181-20.Peer-Reviewed Original Research
2013
The Microbial Spectrum of Neonatal Sepsis in Uganda: Recovery of Culturable Bacteria in Mother-Infant Pairs
Kiwanuka J, Bazira J, Mwanga J, Tumusiime D, Nyesigire E, Lwanga N, Warf B, Kapur V, Poss M, Schiff S. The Microbial Spectrum of Neonatal Sepsis in Uganda: Recovery of Culturable Bacteria in Mother-Infant Pairs. PLOS ONE 2013, 8: e72775. PMID: 24013829, PMCID: PMC3754959, DOI: 10.1371/journal.pone.0072775.Peer-Reviewed Original ResearchConceptsNeonatal sepsisMother-infant pairsVaginal specimensConsecutive mother-infant pairsMicrobial spectrumSeptic newborn infantsCerebrospinal fluid culturesBacterial culture techniquesSensitive molecular approachesClinical criteriaNewborn infantsPutative causative agentFluid cultureInfant bloodMaternal bloodSepsisCerebrospinal fluidSpinal fluidInfantsBloodCausative agentMaternal transmissionEnvironmental sourcesIdentifiable bacteriaCulture techniques
2011
Association of bacteria with hydrocephalus in Ugandan infants.
Li L, Padhi A, Ranjeva S, Donaldson S, Warf B, Mugamba J, Johnson D, Opio Z, Jayarao B, Kapur V, Poss M, Schiff S. Association of bacteria with hydrocephalus in Ugandan infants. Journal Of Neurosurgery Pediatrics 2011, 7: 73-87. PMID: 21194290, DOI: 10.3171/2010.9.peds10162.Peer-Reviewed Original ResearchConceptsUgandan infantsNeonatal sepsisPostinfectious hydrocephalusMajority of patientsMost patientsRecent infectionPolymerase chain reactionEffective treatmentPatientsPrevention strategiesHydrocephalusInfectionInfantsAcinetobacter speciesChain reactionAssociation of bacteriaBacterial DNAGram-negative bacteriaNegative bacteriaSepsisEnvironmental samplingSyndromeSeason infection