2021
Spreading depression as an innate antiseizure mechanism
Tamim I, Chung D, de Morais A, Loonen I, Qin T, Misra A, Schlunk F, Endres M, Schiff S, Ayata C. Spreading depression as an innate antiseizure mechanism. Nature Communications 2021, 12: 2206. PMID: 33850125, PMCID: PMC8044138, DOI: 10.1038/s41467-021-22464-x.Peer-Reviewed Original ResearchConceptsFocal neocortical seizuresSystemic kainic acidCentral nervous systemVivo mouse modelAntiseizure mechanismsAntiseizure effectsSeizure generalizationFocal seizuresSD occurrenceNeocortical seizuresKainic acidBrain injuryMouse modelNervous systemSeizuresNeurological disordersProlonged depolarizationSDDepressionBicucullineMigraineInjury
2012
The role of inhibition in oscillatory wave dynamics in the cortex
Xiao Y, Huang X, Van Wert S, Barreto E, Wu J, Gluckman B, Schiff S. The role of inhibition in oscillatory wave dynamics in the cortex. European Journal Of Neuroscience 2012, 36: 2201-2212. PMID: 22805065, PMCID: PMC4410882, DOI: 10.1111/j.1460-9568.2012.08132.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBicucullineCarbacholEpilepsies, PartialGABA-A Receptor AgonistsGABA-A Receptor AntagonistsGABA-B Receptor AgonistsGABA-B Receptor AntagonistsMaleMembrane PotentialsModels, NeurologicalNeocortexNeural InhibitionPicrotoxinRatsRats, Sprague-DawleyReceptors, AMPAReceptors, GABA-AReceptors, GABA-BReceptors, N-Methyl-D-AspartateTheta RhythmConceptsGABAergic inhibitionNeocortical brain slicesVoltage-sensitive dye imagingSprague-Dawley ratsPresence of carbacholConcentration-dependent mannerGABAB antagonistGABAA receptorsBrain slicesTheta frequency oscillationsPharmacological methodsDye imagingCortical oscillationsRole of inhibitionBicucullineDisinhibitionGABAATheta oscillationsCortexBasic spatiotemporal patternsInhibitionNeural information processingCarbacholMental tasksAntagonist