2022
CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel
Midgett D, Thorn S, Ahn S, Uman S, Avendano R, Melvinsdottir I, Lysyy T, Kim J, Duncan J, Humphrey J, Papademetris X, Burdick J, Sinusas A. CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel. Journal Of Molecular And Cellular Cardiology 2022, 166: 74-90. PMID: 35227737, PMCID: PMC9035115, DOI: 10.1016/j.yjmcc.2022.02.004.Peer-Reviewed Original Research
2019
Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling
Thorn SL, Barlow SC, Feher A, Stacy MR, Doviak H, Jacobs J, Zellars K, Renaud JM, Klein R, deKemp RA, Khakoo AY, Lee T, Spinale FG, Sinusas AJ. Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling. Circulation Cardiovascular Imaging 2019, 12: e009055. PMID: 31707811, PMCID: PMC7250243, DOI: 10.1161/circimaging.119.009055.Peer-Reviewed Original ResearchConceptsMyocardial blood flowSingle photon emissionBlood flowRecombinant TIMP-3Matrix metalloproteinasesR injuryTomography/Intracoronary deliveryMMP activationPost-myocardial infarction remodelingSubsequent left ventricular remodelingHybrid single-photon emissionDual-isotope single-photon emissionTomography/Computed Tomography ImagingLeft ventricular remodelingIschemia/reperfusionPost-MI remodelingPost-myocardial infarctionComputed tomography (CT) imagingIntracoronary infusionVentricular functionSaline groupVentricular remodelingNoninvasive evaluationTreatment groupsA robust segmentation method with triple‐factor non‐negative matrix factorization for myocardial blood flow quantification from dynamic 82Rb positron emission tomography
Liu H, Wu J, Sun J, Wu T, Fazzone‐Chettiar R, Thorn S, Sinusas AJ, Liu Y. A robust segmentation method with triple‐factor non‐negative matrix factorization for myocardial blood flow quantification from dynamic 82Rb positron emission tomography. Medical Physics 2019, 46: 5002-5013. PMID: 31444909, DOI: 10.1002/mp.13783.Peer-Reviewed Original Research
2016
Effects of an endothelin receptor antagonist, Macitentan, on right ventricular substrate utilization and function in a Sugen 5416/hypoxia rat model of severe pulmonary arterial hypertension
Drozd K, Ahmadi A, Deng Y, Jiang B, Petryk J, Thorn S, Stewart D, Beanlands R, deKemp RA, DaSilva JN, Mielniczuk LM. Effects of an endothelin receptor antagonist, Macitentan, on right ventricular substrate utilization and function in a Sugen 5416/hypoxia rat model of severe pulmonary arterial hypertension. Journal Of Nuclear Cardiology 2016, 24: 1979-1989. PMID: 27688036, DOI: 10.1007/s12350-016-0663-4.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionRV FDG uptakePositron emission tomographyFDG uptakeFTHA uptakeFatty acid metabolismArterial hypertensionRV functionMacitentan treatmentRat modelSevere pulmonary arterial hypertensionWeek 5Effect of macitentanImproved RV functionRV systolic pressureWeeks of hypoxiaEndothelin receptor antagonistsRV ejection fractionHypoxia rat modelSingle subcutaneous injectionMale Sprague-DawleyAcid metabolismMyocardial energy metabolismPAH severitySugen 5416
2012
A three-dimensional model-based partial volume correction strategy for gated cardiac mouse PET imaging
Dumouchel T, Thorn S, Kordos M, DaSilva J, Beanlands RS, deKemp RA. A three-dimensional model-based partial volume correction strategy for gated cardiac mouse PET imaging. Physics In Medicine And Biology 2012, 57: 4309-4334. PMID: 22705820, DOI: 10.1088/0031-9155/57/13/4309.Peer-Reviewed Original Research
2010
Alterations of pre- and postsynaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicity
Kenk M, Thackeray JT, Thorn SL, Dhami K, Chow BJ, Ascah KJ, DaSilva JN, Beanlands RS. Alterations of pre- and postsynaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicity. Journal Of Nuclear Cardiology 2010, 17: 254-263. PMID: 20182926, DOI: 10.1007/s12350-009-9190-x.Peer-Reviewed Original ResearchConceptsPositron emission tomographyRat modelNoradrenergic signalingHeart/body weight ratioBeta-adrenergic receptor antagonistMyocardial noradrenaline levelsSympathetic nervous systemBody weight ratioPhosphodiesterase 4 inhibitorBeta-adrenergic receptorsVentricle free wallAnthracycline chemotherapeutic agentDesipramine treatmentNoradrenaline levelsNoradrenaline uptakeAnthracycline cardiotoxicityReceptor antagonistAcute increaseCardiac functionRight ventricleLeft atriumInteraction of preAdriamycin cardiotoxicityFree wallNervous system