2016
Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method
Wu J, Lin SF, Gallezot JD, Chan C, Prasad R, Thorn S, Stacy MR, Huang Y, Zonouz TH, Liu YH, Lampert RJ, Carson RE, Sinusas AJ, Liu C. Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method. Journal Of Nuclear Medicine 2016, 57: 1226-1232. PMID: 27081169, DOI: 10.2967/jnumed.115.171710.Peer-Reviewed Original Research3-IodobenzylguanidineAdultAgedAlgorithmsArtifactsComputer SimulationFemaleHeartHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMiddle AgedModels, CardiovascularModels, StatisticalMyocardiumRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificityTissue DistributionTomography, Emission-Computed, Single-PhotonEditorial in response to: PET/CT evaluation of 18F-FDG uptake in pericoronary adipose tissue in patients with stable coronary artery disease: Independent predictor of atherosclerotic lesion formation? Is there prognostic value in evaluation of 18F-FDG uptake in the pericoronary adipose tissue?
Thorn SL, Sinusas AJ. Editorial in response to: PET/CT evaluation of 18F-FDG uptake in pericoronary adipose tissue in patients with stable coronary artery disease: Independent predictor of atherosclerotic lesion formation? Is there prognostic value in evaluation of 18F-FDG uptake in the pericoronary adipose tissue? Journal Of Nuclear Cardiology 2016, 24: 1085-1088. PMID: 26976143, DOI: 10.1007/s12350-016-0458-7.Peer-Reviewed Original Research
2015
Scatter and crosstalk corrections for 99mTc/123I dual‐radionuclide imaging using a CZT SPECT system with pinhole collimators
Fan P, Hutton BF, Holstensson M, Ljungberg M, Pretorius P, Prasad R, Ma T, Liu Y, Wang S, Thorn SL, Stacy MR, Sinusas AJ, Liu C. Scatter and crosstalk corrections for 99mTc/123I dual‐radionuclide imaging using a CZT SPECT system with pinhole collimators. Medical Physics 2015, 42: 6895-6911. PMID: 26632046, DOI: 10.1118/1.4934830.Peer-Reviewed Original ResearchConceptsDual-radionuclide imagingCrosstalk correction methodTEW methodLine source experimentDefect contrastSource experimentsMonte Carlo simulationsIncomplete charge collectionCadmium zinc telluride detectorsLow-energy tailImaging systemCarlo simulationsPinhole collimatorCardiac SPECT systemEnergy tailDetector effectsEnergy spectrumPoint source measurementsSPECT systemCZT detectorsTriple energy window (TEW) methodScatter modelDedicated cardiac SPECT systemsCorrection methodCrosstalk correction
2013
Repeatable Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDG: Evaluation of Tracer Kinetics in a Type 1 Diabetes Model
Thorn SL, deKemp RA, Dumouchel T, Klein R, Renaud JM, Wells RG, Gollob MH, Beanlands RS, DaSilva JN. Repeatable Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDG: Evaluation of Tracer Kinetics in a Type 1 Diabetes Model. Journal Of Nuclear Medicine 2013, 54: 1637-1644. PMID: 23940301, DOI: 10.2967/jnumed.112.110114.Peer-Reviewed Original ResearchConceptsMyocardial glucose uptakeImage-derived blood input functionAcute insulin treatmentInsulin treatmentBlood activityType 1 diabetic miceType 1 diabetic mouse modelML/min/Glucose uptakeVena cava diameterMyocardial glucose uptake ratesDiabetic mouse modelType 1 diabetesStandardized uptake valueTest-retest repeatabilityAcute insulin stimulationDiabetic miceCoefficient of repeatabilityFDG-PETBland-Altman analysisMyocardial glucoseContrast CTBaseline scanMouse modelTime-activity curves
2010
Kinetic model‐based factor analysis of dynamic sequences for 82‐rubidium cardiac positron emission tomography
Klein R, Beanlands RS, Wassenaar RW, Thorn SL, Lamoureux M, DaSilva JN, Adler A, deKemp RA. Kinetic model‐based factor analysis of dynamic sequences for 82‐rubidium cardiac positron emission tomography. Medical Physics 2010, 37: 3995-4010. PMID: 20879561, DOI: 10.1118/1.3438474.Peer-Reviewed Original ResearchIntra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program
Klein R, Renaud JM, Ziadi MC, Thorn SL, Adler A, Beanlands RS, deKemp RA. Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program. Journal Of Nuclear Cardiology 2010, 17: 600-616. PMID: 20387135, DOI: 10.1007/s12350-010-9225-3.Peer-Reviewed Original Research
2008
Collagen-Based Matrices Improve the Delivery of Transplanted Circulating Progenitor Cells
Zhang Y, Thorn S, DaSilva JN, Lamoureux M, deKemp RA, Beanlands RS, Ruel M, Suuronen EJ. Collagen-Based Matrices Improve the Delivery of Transplanted Circulating Progenitor Cells. Circulation Cardiovascular Imaging 2008, 1: 197-204. PMID: 19808543, DOI: 10.1161/circimaging.108.781120.Peer-Reviewed Original ResearchConceptsPositron emission tomographyIschemic hind limbIschemic hind limb musclesCirculating Progenitor CellsHind limbProgenitor cellsRats 2 weeksFemoral artery ligationNonspecific tissueHind limb musclesMechanism of actionEarly posttransplantationCollagen matrixSmall animal positron emission tomographyArtery ligationMinutes postinjectionProgenitor cell retentionAnimal positron emission tomographyLimb musclesCell therapyHuman CPCsTarget tissuesPosttransplantationTomographyFDG
2006
In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues
Kenk M, Greene M, Thackeray J, deKemp RA, Lortie M, Thorn S, Beanlands RS, DaSilva JN. In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues. Nuclear Medicine And Biology 2006, 34: 71-77. PMID: 17210463, DOI: 10.1016/j.nucmedbio.2006.10.002.Peer-Reviewed Original ResearchMeSH Keywords3',5'-Cyclic-AMP PhosphodiesterasesAnimalsBrainCarbon RadioisotopesCyclic AMPCyclic Nucleotide Phosphodiesterases, Type 1Cyclic Nucleotide Phosphodiesterases, Type 4HeartMaleMetabolic Clearance RateMyocardiumOrgan SpecificityPhosphodiesterase InhibitorsProtein BindingRadionuclide ImagingRadiopharmaceuticalsRatsRats, Sprague-DawleyRolipramSensitivity and SpecificityTissue DistributionConceptsPhosphodiesterase 4BAY 60Ro 20Male Sprague-Dawley ratsIntracellular cAMPSprague-Dawley ratsNeurohormonal modulationPeripheral tissuesAutoradiography studiesAdipose tissuePDE4 levelsTracer uptakeVivo findingsCAMP-mediated signalingBiodistribution studiesPDE4 activityRolipramSkeletal muscleCAMP levelsTracer retentionCardiac regionCilostazolMyocardiumZaprinastTissue