2021
Arteriovenous fistula-induced cardiac remodeling shows cardioprotective features in mice
Lee SR, Thorn S, Guerrera N, Gonzalez L, Taniguchi R, Langford J, Sinusas AJ, Dardik A. Arteriovenous fistula-induced cardiac remodeling shows cardioprotective features in mice. JVS Vascular Science 2021, 2: 110-128. PMID: 34423320, PMCID: PMC8375600, DOI: 10.1016/j.jvssci.2021.05.002.Peer-Reviewed Original ResearchArteriovenous fistulaCardiac hypertrophyCardioprotective featuresRelative LV wall thicknessPoor cardiac outcomesRight heart functionSham-operated miceAdaptive cardiac hypertrophyLV wall thicknessSignificant sex-dependent differencesAreas of fibrosisInflammation-related genesPhysiologic cardiac hypertrophyCardiac chamber sizeCardiac fetal genesWild-type miceSex-dependent differencesSimilar body weightIngenuity Pathway AnalysisArrhythmogenic featuresAVF miceSerial echocardiographyCardiac outcomesDiastolic functionLV systolic
2015
Insulin therapy normalizes reduced myocardial β-adrenoceptors at both the onset and after sustained hyperglycemia in diabetic rats
Haley JM, Thackeray JT, Kolajova M, Thorn SL, DaSilva JN. Insulin therapy normalizes reduced myocardial β-adrenoceptors at both the onset and after sustained hyperglycemia in diabetic rats. Life Sciences 2015, 132: 101-107. PMID: 25934520, DOI: 10.1016/j.lfs.2015.03.024.Peer-Reviewed Original ResearchConceptsCardiac β-ARPositron emission tomographyΒ-ARHeart rateInsulin therapyDiabetes mellitusΒ-adrenoceptorsCV functionWestern blottingInsulin effectDuration of hyperglycemiaMyocardial β-adrenoceptorsΒ-AR expressionOnset of hyperglycemiaWeeks of hyperglycemiaCardiac β-adrenoceptorsΒ-AR subtypesReduced heart rateMyocardial β-ARsGlycemic therapyStreptozotocin ratsSerial echocardiographySTZ ratsGlycemic controlCardiovascular dysfunction