2013
β-Adrenoceptor Expression is Reduced in Zucker Diabetic Fatty Rats and Increased in Euglycemic Zucker Obese Rats After 6 Weeks of Sustained Hyperglycemia
Haley J, Thackeray J, Thorn S, Beanlands R, Dasilva J. β-Adrenoceptor Expression is Reduced in Zucker Diabetic Fatty Rats and Increased in Euglycemic Zucker Obese Rats After 6 Weeks of Sustained Hyperglycemia. Canadian Journal Of Diabetes 2013, 37: s64-s65. DOI: 10.1016/j.jcjd.2013.08.194.Peer-Reviewed Original Research
2009
Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats
Greene M, Thackeray JT, Kenk M, Thorn SL, Bevilacqua L, Harper ME, Beanlands RS, DaSilva JN. Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats. Canadian Journal Of Physiology And Pharmacology 2009, 87: 196-202. PMID: 19295660, DOI: 10.1139/y09-001.Peer-Reviewed Original ResearchConceptsDiet-induced obeseDR ratsDiet-induced obese ratsObese animal modelsSympathetic nervous activityPersistence of obesityHigh-fat dietPhosphodiesterase 4 inhibitorWeeks of feedingEnergy expenditure measuresDIO animalsNoradrenaline challengeDesipramine pretreatmentObese ratsCaloric intakeNoradrenaline stimulationNervous activityAnimal modelsPDE4 levelsNormal increaseWeight gainH pretreatmentSkeletal muscleRatsProgressive alteration