2015
Cardiac β-Adrenoceptor Expression Is Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes Progresses
Haley JM, Thackeray JT, Thorn SL, DaSilva JN. Cardiac β-Adrenoceptor Expression Is Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes Progresses. PLOS ONE 2015, 10: e0127581. PMID: 25996498, PMCID: PMC4440709, DOI: 10.1371/journal.pone.0127581.Peer-Reviewed Original ResearchConceptsZucker diabetic fattyΒ-AR expressionWeeks of ageΒ2-AR expressionΒ-adrenoceptor expressionZDF ratsΒ3-ARFree fatty acidsType 2 diabetic Zucker diabetic fattyType 2 diabetic ZDF ratsDiabetic Zucker diabetic fattyZucker diabetic fatty ratsType 2 diabetes progressesType 2 diabetes modelWestern blottingCardiac β-ARΒ1-AR expressionDiabetic fatty ratsDiabetic ZDF ratsType 2 diabetesModel of hyperglycemiaΒ-AR subtypesBrown adipose tissueDiastolic functionSystolic function
2013
MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16
Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, van IJcken W, Grosveld F, Dekemp RA, Boushel R, Harper ME, Rudnicki MA. MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16. Cell Metabolism 2013, 17: 210-224. PMID: 23395168, PMCID: PMC3641657, DOI: 10.1016/j.cmet.2013.01.004.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsAdipocytes, BrownAdipose Tissue, BrownAnimalsBase SequenceCell DifferentiationCell LineageCold TemperatureDNA-Binding ProteinsDown-RegulationEnergy MetabolismGlucose Tolerance TestMiceMicroRNAsMolecular Sequence DataMultipotent Stem CellsRegenerationSatellite Cells, Skeletal MuscleTranscription FactorsConceptsAdult skeletal muscle stem cellsSkeletal muscle stem cellsBrown adipocytesSkeletal muscle satellite cellsMuscle stem cellsSatellite cellsAdult satellite cellsLineage-tracing experimentsMuscle satellite cellsMyogenic lineageEmbryonic developmentMyogenic progenitorsMicroRNA-133De novo generationMiR-133 levelsBrown adipose tissueWhole-body energy expenditureMuscle regenerationUncoupled respirationEnergy metabolismStem cellsImportant therapeutic targetNovo generationThermogenic tissuesGlucose uptake