2015
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy
Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT. ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nature Communications 2015, 6: 10006. PMID: 26624227, PMCID: PMC4686714, DOI: 10.1038/ncomms10006.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseVascular calcificationArterial calcificationOrphan diseaseCommon diseaseSequelae of diseaseEctopic vascular calcificationInternal elastic laminaPrevent mortalityRenal failureCardiac failureKidney diseaseSubcutaneous administrationRodent modelsAnimal modelsEctopic calcificationVascular wallLarge arteriesElastic laminaDiseaseCalcificationCalciphylaxisDecreased concentrationSclerosisArtery
2009
Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats
Greene M, Thackeray JT, Kenk M, Thorn SL, Bevilacqua L, Harper ME, Beanlands RS, DaSilva JN. Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats. Canadian Journal Of Physiology And Pharmacology 2009, 87: 196-202. PMID: 19295660, DOI: 10.1139/y09-001.Peer-Reviewed Original ResearchConceptsDiet-induced obeseDR ratsDiet-induced obese ratsObese animal modelsSympathetic nervous activityPersistence of obesityHigh-fat dietPhosphodiesterase 4 inhibitorWeeks of feedingEnergy expenditure measuresDIO animalsNoradrenaline challengeDesipramine pretreatmentObese ratsCaloric intakeNoradrenaline stimulationNervous activityAnimal modelsPDE4 levelsNormal increaseWeight gainH pretreatmentSkeletal muscleRatsProgressive alteration