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Shirin Bahmanyar, PhD

Associate Professor Tenure of Molecular, Cellular and Developmental Biology
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Assistant Professor

About

Titles

Associate Professor Tenure of Molecular, Cellular and Developmental Biology

Assistant Professor

Biography

Dr. Bahmanyar received her undergraduate degree from UC Berkeley and her Ph.D. from Stanford University. She was a post-doctoral fellow with Dr. Karen Oegema at the Ludwig Institute for Cancer Research at UC San Diego where she recognized the advantages of the early C. elegans embryo as a tractable model system to dissect mechanisms that control nuclear envelope dynamics to ensure genome protection. Her post-doctoral work with elucidated an important new principle involving local regulation of phospholipid synthesis in specifying the nuclear envelope domain within the continuous endoplasmic reticulum (ER). Her work now is focused on elucidating mechanisms underpinning regulatory roles for lipid composition and dynamics in nuclear envelope and ER membrane remodeling and genome protection.

Appointments

Education & Training

Post-doctoral Researcher
Ludwig Institute for Cancer Research/UCSD (2013)
PhD
Stanford University (2008)
BA
University of California, Berkeley (2001)

Research

Overview

Our lab is interested in mechanisms that drive organelle structure, identity, and dynamics. In particular, we study the nuclear envelope - a specialized compartment that surrounds and protects the genome. The nuclear envelope is highly dynamic in both interphase and mitotic cells. Defects in nuclear envelope dynamics cause DNA damage and disrupt nuclear functions and as such are highly relevant to disease, yet little is known about mechanisms that control membrane dynamics at the NE.

Membrane dynamics at nearly all membrane bound organelles depend on the composition of bilayer lipids. Almost nothing is known about the membrane lipid composition of the nuclear envelope. This is in part because the nuclear envelope is not a stand-alone organelle but is continuous with the expansive endoplasmic reticulum (ER) making it difficult to biochemically distinguish between their lipid content. The ER serves as a platform for de novo lipid synthesis. Because lipids diffuse rapidly in the two dimensional network of the ER and nuclear envelope it has long been assumed that their lipid composition is the same. However, emerging evidence suggests that the nuclear envelope harbors distinct regulators of phospholipid metabolism that may lead to its unique lipid composition.

Our lab harnesses the powerful tools to identify genetic pathways and gene function in C. elegans and cutting-edge microscopy approaches amenable to live imaging of mammalian cells to define mechanisms that control nuclear envelope dynamics. We study nuclear envelope reformation in mitosis and interphase nuclear rupture and repair - two specialized processes that require local and global changes in membrane structure and protein recruitment and as such provide tractable systems to dissect the molecular mechanisms underpinning lipid-mediated regulation of nuclear envelope dynamics in genome protection.

Medical Subject Headings (MeSH)

Caenorhabditis elegans; Diseases; Endoplasmic Reticulum; Lamins; Lipid Metabolism; Molecular Biology; Nuclear Envelope; Organelles

Research at a Glance

Yale Co-Authors

Frequent collaborators of Shirin Bahmanyar's published research.

Publications

2024

2023

2022

2021

2020

Academic Achievements & Community Involvement

  • honor

    Women in Cell Biology (WICB) Junior Award for Excellence in Research

  • honor

    NSF CAREER Award

  • honor

    The Hartwell Foundation Postdoctoral Research Fellowship

  • honor

    First Bank of America Fellow of the A.P. Giannini Foundation

  • honor

    A.P. Giannini Foundation Postdoctoral Research Fellowship

Get In Touch

Contacts

Academic Office Number
Lab Number

Locations

  • Yale Science Building

    Academic Office

    260 Whitney Avenue, Ste 116

    New Haven, CT 06511