Insc:LGN tetramers promote asymmetric divisions of mammary stem cells
Culurgioni S, Mari S, Bonetti P, Gallini S, Bonetto G, Brennich M, Round A, Nicassio F, Mapelli M. Insc:LGN tetramers promote asymmetric divisions of mammary stem cells. Nature Communications 2018, 9: 1025. PMID: 29523789, PMCID: PMC5844954, DOI: 10.1038/s41467-018-03343-4.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAsymmetric Cell DivisionCell Cycle ProteinsCytoskeletal ProteinsDrosophilaDrosophila ProteinsGuanine Nucleotide Dissociation InhibitorsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceModels, MolecularProtein BindingStem CellsConceptsMammary stem cellsAsymmetric divisionStem cellsAsymmetric cell divisionStem cell proliferationProtein LGNDrosophila neuroblastsFate specificationFate determinantsTissue morphogenesisAsymmetric fatesCell divisionMicrotubule motorsSymmetric divisionTetrameric arrangementNovel roleAsymmetric domainsInscuteableCell proliferationINSCP53 lossStable coreDivisionCellsTetramer