2024
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
Xin T, Gallini S, Wei H, Gonzalez D, Matte-Martone C, Machida H, Fujiwara H, Pasolli H, Suozzi K, Gonzalez L, Regot S, Greco V. Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation. Nature Cell Biology 2024, 26: 859-867. PMID: 38689013, DOI: 10.1038/s41556-024-01413-y.Peer-Reviewed Original ResearchERK signalingStem cellsSquamous cell carcinomaHair folliclesOncogenic KRAS mutationsCell carcinomaKRAS mutationsSustained ERK activationERK signaling dynamicsOncogenic mutationsOncogenic KRASERK activationStem cell behaviorIntravital imagingAbnormal cell divisionModulates specific featuresKrasG12DTissue deformationSpatiotemporally specific mannerSustained ERK signalingMutationsLiving miceFolliclesTissue disruptionSingle-cell level
2019
Hair follicle regeneration suppresses Ras-driven oncogenic growth
Pineda CM, Gonzalez DG, Matte-Martone C, Boucher J, Lathrop E, Gallini S, Fons NR, Xin T, Tai K, Marsh E, Nguyen DX, Suozzi KC, Beronja S, Greco V. Hair follicle regeneration suppresses Ras-driven oncogenic growth. Journal Of Cell Biology 2019, 218: 3212-3222. PMID: 31488583, PMCID: PMC6781447, DOI: 10.1083/jcb.201907178.Peer-Reviewed Original ResearchConceptsHair folliclesHras mutationsOncogenic growthHair follicle stem cellsSkin hair folliclesTumor developmentFollicle stem cellsHair follicle regenerationSkin epitheliumSecondary mutationsBenign outgrowthFolliclesStem cellsTissueCertain tissuesFollicle regenerationCellsContinuous tissueWild-type neighborsDistinct mechanismsDifferent outcomesMutationsEnhanced capacityInjury
2018
Insc:LGN tetramers promote asymmetric divisions of mammary stem cells
Culurgioni S, Mari S, Bonetti P, Gallini S, Bonetto G, Brennich M, Round A, Nicassio F, Mapelli M. Insc:LGN tetramers promote asymmetric divisions of mammary stem cells. Nature Communications 2018, 9: 1025. PMID: 29523789, PMCID: PMC5844954, DOI: 10.1038/s41467-018-03343-4.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAsymmetric Cell DivisionCell Cycle ProteinsCytoskeletal ProteinsDrosophilaDrosophila ProteinsGuanine Nucleotide Dissociation InhibitorsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceModels, MolecularProtein BindingStem CellsConceptsMammary stem cellsAsymmetric divisionStem cellsAsymmetric cell divisionStem cell proliferationProtein LGNDrosophila neuroblastsFate specificationFate determinantsTissue morphogenesisAsymmetric fatesCell divisionMicrotubule motorsSymmetric divisionTetrameric arrangementNovel roleAsymmetric domainsInscuteableCell proliferationINSCP53 lossStable coreDivisionCellsTetramer