2018
Insc:LGN tetramers promote asymmetric divisions of mammary stem cells
Culurgioni S, Mari S, Bonetti P, Gallini S, Bonetto G, Brennich M, Round A, Nicassio F, Mapelli M. Insc:LGN tetramers promote asymmetric divisions of mammary stem cells. Nature Communications 2018, 9: 1025. PMID: 29523789, PMCID: PMC5844954, DOI: 10.1038/s41467-018-03343-4.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAsymmetric Cell DivisionCell Cycle ProteinsCytoskeletal ProteinsDrosophilaDrosophila ProteinsGuanine Nucleotide Dissociation InhibitorsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceModels, MolecularProtein BindingStem CellsConceptsMammary stem cellsAsymmetric divisionStem cellsAsymmetric cell divisionStem cell proliferationProtein LGNDrosophila neuroblastsFate specificationFate determinantsTissue morphogenesisAsymmetric fatesCell divisionMicrotubule motorsSymmetric divisionTetrameric arrangementNovel roleAsymmetric domainsInscuteableCell proliferationINSCP53 lossStable coreDivisionCellsTetramer
2016
Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation
Carminati M, Gallini S, Pirovano L, Alfieri A, Bisi S, Mapelli M. Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation. Nature Structural & Molecular Biology 2016, 23: 155-163. PMID: 26751642, DOI: 10.1038/nsmb.3152.Peer-Reviewed Original Research
2014
The LGN:Insc tetramer stabilises the apical site in asymmetric cell divisions
Culurgioni S, Mari S, Gallini S, Bonetto G, Mapelli M. The LGN:Insc tetramer stabilises the apical site in asymmetric cell divisions. Acta Crystallographica Section A: Foundations And Advances 2014, 70: c1057-c1057. DOI: 10.1107/s2053273314089426.Peer-Reviewed Original ResearchAsymmetric cell divisionCell divisionPolarity protein Par3Stem cell divisionPolarity proteinsCortical polarityPolarity cuesPDZ regionFate choiceDaughter cellsDevelopmental programStable tetrameric complexMitotic spindleTissue homeostasisMicrotubule motorsNovel functionTetrameric arrangementPar3Concomitant bindingTetrameric complexINSCCortical attachmentNuMABinding assaysDual role