2015
Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome
Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C. Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 893-898. PMID: 25561540, PMCID: PMC4311862, DOI: 10.1073/pnas.1419533112.Peer-Reviewed Original ResearchConceptsTourette syndromeCholinergic interneuronsDorsolateral striatumSensorimotor gatingD-amphetamine challengeLarge cholinergic interneuronsSpecific cell ablationInterneuron deficitsStriatal interneuronsAcute administrationGABAergic markersDopaminergic drugsAvailable treatmentsPostmortem studiesPrepulse inhibitionTic disordersSevere diseaseHuman putamenMotor coordinationInterneuronsTargeted ablationSevere endStriatumAcute stressGilles de
2014
Optogenetic inhibition of neurons by internal light production
Land BB, Brayton CE, Furman KE, LaPalombara Z, DiLeone RJ. Optogenetic inhibition of neurons by internal light production. Frontiers In Behavioral Neuroscience 2014, 8: 108. PMID: 24744708, PMCID: PMC3978322, DOI: 10.3389/fnbeh.2014.00108.Peer-Reviewed Original ResearchOptogenetic inhibitionAmphetamine-induced locomotor activityNeural activityLuciferase-expressing virusesSuppress neural activitySpecific molecular pathwaysAdeno-associated virusLuciferase miceNeuronal activityLocomotor activityNeural circuitsActivation/inhibitionAdministrationMolecular pathwaysFos activityDelivery of lightVivo optogeneticsInhibitionMiceAnimalsVirusLuciferaseOptogeneticsOptical fiberStriatum