2018
Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies
Martin DT, Ghabili K, Levi A, Humphrey PA, Sprenkle PC. Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies. Urology 2018, 125: 64-72. PMID: 30552940, DOI: 10.1016/j.urology.2018.12.001.Peer-Reviewed Original ResearchConceptsPI-RADSv2 scoreDecipher scoreProstate Imaging ReportingDecipher testingTargeted biopsiesRadical prostatectomyData System version 2 (PI-RADS v2) scoreFavorable intermediate-risk prostate cancerIntermediate-risk prostate cancer patientsGleason Grade Group 1Imaging ReportingIntermediate-risk prostate cancerMultivariable logistic regression analysisHigh-risk diseasePI-RADS 4Grade group 1Gleason grade groupProstate cancer patientsMultiparametric magnetic resonancePI-RADS scoreVersion 2 scoreData System scoreLogistic regression analysisSignificant differencesPI-RADS category
2008
Prognostic value of various morphometric measurements of tumour extent in prostate needle core tissue
Brimo F, Vollmer R, Corcos J, Kotar K, Bégin L, Humphrey P, Bismar T. Prognostic value of various morphometric measurements of tumour extent in prostate needle core tissue. Histopathology 2008, 53: 177-183. PMID: 18752501, DOI: 10.1111/j.1365-2559.2008.03087.x.Peer-Reviewed Original ResearchConceptsPathological stageTumor lengthPrognostic valueTumor extentFinal pathological stageHigher stage diseaseNeedle biopsy specimenCancer patient outcomesPrognostic significanceBiochemical recurrenceBiopsy specimenRadical prostatectomyPatient outcomesBiopsy reportingFailure statusCancer lengthPositive coresPathological outcomesLarger studyMorphometric measurementsDiscontinuous fociCancerCore tissuePatientsOutcomes
2004
EFFECT OF THE DUAL 5α-REDUCTASE INHIBITOR DUTASTERIDE ON MARKERS OF TUMOR REGRESSION IN PROSTATE CANCER
ANDRIOLE G, HUMPHREY P, RAY P, GLEAVE M, TRACHTENBERG J, THOMAS L, LAZIER C, RITTMASTER R. EFFECT OF THE DUAL 5α-REDUCTASE INHIBITOR DUTASTERIDE ON MARKERS OF TUMOR REGRESSION IN PROSTATE CANCER. Journal Of Urology 2004, 172: 915-919. PMID: 15310997, DOI: 10.1097/01.ju.0000136430.37245.b9.Peer-Reviewed Original ResearchConceptsProstate cancerMicrovessel densityDutasteride treatmentIntraprostatic dihydrotestosteroneTumor regressionDual 5α-Reductase Inhibitor DutasterideShort-term pilot studyDays of placeboEffect of dutasterideIntraprostatic androgen levelsT2 prostate cancerDegree of atrophyProstate cancer treatmentShort-term treatmentProstate cancer tissuesIndex of apoptosisRadical prostatectomyEarly treatmentAndrogen levelsDutasterideCancer tissuesResected tissuesDHT formationDihydrotestosteroneType 1
2001
The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer
Vollmer R, Humphrey P. The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer. American Journal Of Clinical Pathology 2001, 116: 864-870. PMID: 11764075, DOI: 10.1309/7mq7-mwar-4w8a-r75f.Peer-Reviewed Original ResearchConceptsElevated PSA levelsEarly deathPSA levelsRadical prostatectomyProstate cancerPathology observationsGleason grade 5Overall good prognosisTime of prostatectomyPostoperative levelsPSA failureStudy patientsBetter prognosisProgressive tumorsPrognostic categoriesPercentage carcinomaProstatectomySubsequent outcomesLower hazardDeathSurgeryHigher hazardCancerMenPSA
2000
Visual estimate of the percentage of carcinoma is an independent predictor of prostate carcinoma recurrence after radical prostatectomy
Carvalhal G, Humphrey P, Thorson P, Yan Y, Ramos C, Catalona W. Visual estimate of the percentage of carcinoma is an independent predictor of prostate carcinoma recurrence after radical prostatectomy. Cancer 2000, 89: 1308-1314. PMID: 11002227, DOI: 10.1002/1097-0142(20000915)89:6<1308::aid-cncr16>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsPercentage of carcinomaGroup of patientsDisease recurrenceRadical prostatectomyRadical prostatectomy specimensIndependent predictorsPathologic stageGleason scoreTumor recurrenceProstate carcinomaProstatectomy specimensPreoperative prostate-specific antigen levelProstate-specific antigen levelKaplan-Meier product limit estimatesCox proportional hazards modelProstatic tissue specimensPathologic tumor stageKaplan-Meier methodRecurrence-free survivalSpecific antigen levelsImportant prognostic informationCox proportional hazardsProportional hazards modelProstate carcinoma recurrenceTumor size measurements
1998
Predicting the pathology results of radical prostatectomy from preoperative information
Vollmer R, Keetch D, Humphrey P. Predicting the pathology results of radical prostatectomy from preoperative information. Cancer 1998, 83: 1567-1580. PMID: 9781951, DOI: 10.1002/(sici)1097-0142(19981015)83:8<1567::aid-cncr12>3.0.co;2-e.Peer-Reviewed Original ResearchConceptsRadical prostatectomyPreoperative informationNeedle biopsyTumor volumeStatistical methodsWashington University Medical CenterAdvanced tumor stageProstate-specific antigenUniversity Medical CenterPreoperative variablesSerum PSATumor stagePathology resultsPathology outcomesMedical CenterProstate carcinomaSpecific antigenProstatectomyLogistic regressionBinary outcomesMultivariate modelProbabilityOutcomesBiopsyObserved probabilityPseudohyperplastic Prostatic Adenocarcinoma
Humphrey P, Kaleem Z, Swanson P, Vollmer R. Pseudohyperplastic Prostatic Adenocarcinoma. The American Journal Of Surgical Pathology 1998, 22: 1239-1246. PMID: 9777986, DOI: 10.1097/00000478-199810000-00009.Peer-Reviewed Original ResearchConceptsCases of adenocarcinomaProstatic adenocarcinomaHyperplastic featuresNeedle biopsyProstate carcinoma growthUsual epithelial hyperplasiaProstatic needle biopsyLow Gleason scoreLow-grade carcinomaRadical prostatectomy specimensRadical prostatectomy tissueGleason pattern 2Cystic dilatationPathologic stagePrognostic implicationsTumor sizeGleason scoreHistologic gradePapillary infoldingsRadical prostatectomyUsual hyperplasiaHistologic variantsPrognostic informationProstatic carcinomaCarcinomatous fociPercentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening Population fn1fn1This study was supported in part by a grant from Hybritech Incorporated, San Diego, California.
Arcangeli C, Humphrey P, Smith D, Harmon T, Shepherd D, Keetch D, Catalona W. Percentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening Population fn1fn1This study was supported in part by a grant from Hybritech Incorporated, San Diego, California. Urology 1998, 51: 558-565. PMID: 9586607, DOI: 10.1016/s0090-4295(98)00035-1.Peer-Reviewed Original ResearchConceptsProstate-specific antigenProstate cancerPathologic featuresFree serum prostate-specific antigenSerum prostate-specific antigenFree prostate-specific antigenCancerous surgical marginsProstate cancer screeningPercentage of cancerRadical prostatectomy specimenHarmless cancersPreoperative predictorsWatchful waitingSurgical marginsCapsular penetrationProstatic capsuleGleason scoreCancer screeningRadical prostatectomyProstatectomy specimenTumor volumeFPSAClinical practiceCancerScreening evaluation
1993
Is Prostate Specific Antigen of Clinical Importance in Evaluating Outcome after Radical Prostatectomy
Frazier H, Robertson J, Humphrey P, Paulson D. Is Prostate Specific Antigen of Clinical Importance in Evaluating Outcome after Radical Prostatectomy. Journal Of Urology 1993, 149: 516-518. PMID: 7679755, DOI: 10.1016/s0022-5347(17)36132-3.Peer-Reviewed Original ResearchConceptsProstate-specific antigenPostoperative serum PSA levelsSerum PSA levelsPSA levelsPSA elevationSpecific antigenPostoperative prostate-specific antigenSerum prostate-specific antigenPostoperative PSA levelMargin-positive diseaseRadical perineal prostatectomySerum acid phosphatasePositive diseaseBone scanCurative therapyLocal recurrenceTreatment courseRadical prostatectomyMalignant diseasePerineal prostatectomyClinical failureProstate cancerPositive groupPatientsClinical importanceStratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels
Humphrey P, Frazier H, Vollmer R, Paulson D. Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels. Cancer 1993, 71: 1821-1827. PMID: 7680602, DOI: 10.1002/1097-0142(19930301)71:5<1821::aid-cncr2820710517>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsPostoperative PSA levelPostoperative serum PSA levelsSerum PSA levelsRadical prostatectomy specimensIntraglandular tumor extentPSA levelsPathologic stageMargin positivityProstate-specific antigenHistologic gradeProstatectomy specimensResidual carcinomaPathologic featuresTumor extentSerum prostate-specific antigen levelPercentage carcinomaProstate-specific antigen levelExtension of carcinomaGleason histologic gradeOrgan-confined carcinomaLogistic regression analysisImportant morphologic parametersIntraglandular carcinomaAntigen levelsRadical prostatectomy