2024
Deviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization
Zhang Z, Pu Y, Yu L, Bai H, Duan W, Liu X, Nie X, Wen Z, Zheng L, Hu X, Leng X, Pan Y, Petersen N, Liu L. Deviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization. Journal Of The American Heart Association 2024, 13: e033633. PMID: 38533955, PMCID: PMC11179781, DOI: 10.1161/jaha.123.033633.Peer-Reviewed Original ResearchConceptsBlood pressure targetsBlood pressureAutoregulatory limitsWorse outcomesAssociated with symptomatic intracranial hemorrhageAssociated with unfavorable clinical outcomesPressure targetsAssociated with worse outcomesAssociated with poor outcomesSignificant infarction growthSymptomatic intracranial hemorrhageUnfavorable clinical outcomeLarge vessel occlusion strokeAcute ischemic strokeMean velocity indexIntracranial hemorrhageBP management strategiesNeurological deteriorationClinical outcomesInfarct growthPoor outcomeEndovascular thrombectomyOcclusion strokeRecanalizationIschemic strokeAnesthetic management for large vessel occlusion acute ischemic stroke with tandem lesions
Farooqui M, Galecio-Castillo M, Hassan A, Divani A, Jumaa M, Ribo M, Petersen N, Abraham M, Fifi J, Guerrero W, Malik A, Siegler J, Nguyen T, Sheth S, Yoo A, Linares G, Janjua N, Quispe-Orozco D, Tekle W, Sabbagh S, Zaidi S, Gadea M, Prasad A, Qureshi A, De Leacy R, Abdalkader M, Salazar-Marioni S, Soomro J, Gordon W, Turabova C, Rodriguez-Calienes A, Vivanco-Suarez J, Mokin M, Yavagal D, Jovin T, Ortega-Gutierrez S. Anesthetic management for large vessel occlusion acute ischemic stroke with tandem lesions. Journal Of NeuroInterventional Surgery 2024, jnis-2023-021360. PMID: 38429099, DOI: 10.1136/jnis-2023-021360.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageModified Rankin scoreFavorable functional outcomeAlberta Stroke Program Early CT ScoreNational Institutes of Health Stroke ScaleEndovascular therapyInternal carotid arteryFunctional outcomesAcute ischemic strokeProcedural sedationExcellent recanalizationTandem lesionsAssociated with superior functional outcomesBaseline Alberta Stroke Program Early CT ScoreAnesthetic strategyRecanalization timeAnterior circulation tandem lesionsGeneral anesthesiaAnesthetic techniqueDegree of internal carotid arteryInternal carotid artery stentingOptimal anesthetic strategyIschemic strokeLarge vessel occlusion acute ischemic strokeAcute ischemic stroke patientsBlood Pressure Trajectories and Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke
Katsanos A, Joundi R, Palaiodimou L, Ahmed N, Kim J, Goyal N, Maier I, de Havenon A, Anadani M, Matusevicius M, Mistry E, Khatri P, Arthur A, Sarraj A, Yaghi S, Shoamanesh A, Catanese L, Psychogios M, Tsioufis K, Malhotra K, Spiotta A, Sandset E, Alexandrov A, Petersen N, Tsivgoulis G. Blood Pressure Trajectories and Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke. Hypertension 2024, 81: 629-635. PMID: 38164751, PMCID: PMC11289690, DOI: 10.1161/hypertensionaha.123.22164.Peer-Reviewed Original ResearchAcute ischemic strokeEndovascular thrombectomyIschemic strokeSBP trajectoriesOdds ratioSystolic blood pressure trajectoriesEarly neurological deteriorationSevere stroke syndromesVascular risk factorsBlood pressure valuesStudy of patientsBlood pressure trajectoriesTrajectory groupsMixed effects regression modelsStroke syndromeSuccessful recanalizationTotal patientsNeurological deteriorationAdjusted analysisIntracranial hemorrhagePotential confoundersRisk factorsCommon odds ratioHigh prevalenceSBP measurements
2023
Association between intraprocedural drops in blood pressure and infarct growth rate patterns after acute large-vessel occlusions
Galecio-Castillo M, Quispe-Orozco D, Farooqui M, Dajles A, Vivanco-Suarez J, Rodriguez-Calienes A, Prasad A, Begunova L, Petersen N, Ortega-Gutierrez S. Association between intraprocedural drops in blood pressure and infarct growth rate patterns after acute large-vessel occlusions. Journal Of NeuroInterventional Surgery 2023, jnis-2023-020899. PMID: 37923382, PMCID: PMC11271969, DOI: 10.1136/jnis-2023-020899.Peer-Reviewed Original ResearchRelative cerebral blood flowInfarct growth ratesFinal infarct volumeHypoperfusion intensity ratioAlberta Stroke Program Early CT ScoreMedian arterial pressureDiffusion-weighted imaging (DWI) magnetic resonance imagingCerebral infarction 2Modified Rankin scoreLarge vessel occlusionEndovascular therapyInfarct volumeStroke onsetBlood pressureAcute large vessel occlusionHealth Stroke Scale scoreStroke Scale scoreAcute ischemic strokeCohort observational studySubgroup of patientsCerebral blood flowBlood pressure dropLVO-AISRankin scoreInfarct growthSafety of Intravenous Cangrelor Versus Dual Oral Antiplatelet Loading Therapy in Endovascular Treatment of Tandem Lesions: An Observational Cohort Study
Rodriguez‐Calienes A, Oliver M, Hassan A, Vivanco‐Suarez J, Divani A, Ribo M, Petersen N, Abraham M, Fifi J, Guerrero W, Malik A, Siegler J, Nguyen T, Sheth S, Yoo A, Linares G, Janjua N, Quispe‐Orozco D, Galecio‐Castillo M, Alhajala H, Malaga M, Farooqui M, Jovin T, Jumaa M, Ortega‐Gutierrez S. Safety of Intravenous Cangrelor Versus Dual Oral Antiplatelet Loading Therapy in Endovascular Treatment of Tandem Lesions: An Observational Cohort Study. Stroke Vascular And Interventional Neurology 2023, 3 DOI: 10.1161/svin.123.001020.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageIntravenous cangrelorIntracranial hemorrhageStent thrombosisSafety profilePetechial hemorrhagesTandem lesionsType 2Parenchymal hematoma type 2Inverse probabilityInternational multicenter cohortSimilar safety profileAcute ischemic strokeObservational cohort studyMyocardial infarction protocolDAPT regimensIntraprocedural administrationLoading therapyAntiplatelet therapyCohort studyIschemic strokeLesion interventionMulticenter cohortEndovascular treatmentInfarction protocolsAssociation of Blood Pressure Variability With Death and Discharge Destination Among Critically Ill Patients With and Without Stroke
Stulberg E, Harris B, Zheutlin A, Delic A, Sheibani N, Anadani M, Yaghi S, Petersen N, de Havenon A. Association of Blood Pressure Variability With Death and Discharge Destination Among Critically Ill Patients With and Without Stroke. Neurology 2023, 101: e1145-e1157. PMID: 37487742, PMCID: PMC10513881, DOI: 10.1212/wnl.0000000000207599.Peer-Reviewed Original ResearchConceptsAverage real variabilityNonstroke patientsDischarge destinationHospital deathIschemic strokeIll patientsIllness severityWorse outcomesAdult intensive care unit patientsMinimum mean arterial pressureIntensive care unit patientsIntensive Care III databaseBlood pressure goalsAcute ischemic strokeMean arterial pressureBlood pressure variabilityCare unit patientsRisk of deathMedical Information MartUnit patientsArterial pressureIntracerebral hemorrhageSubarachnoid hemorrhageRisk factorsEffect modificationInvestigating the Relationship Between Oximetry Trends During Endovascular Therapy and Neurological Worsening for Patients with Acute Ischemic Stroke (S24.006)
Olexa M, Begunova Y, Bartolome D, Peng T, Matouk C, Sheth K, Petersen N. Investigating the Relationship Between Oximetry Trends During Endovascular Therapy and Neurological Worsening for Patients with Acute Ischemic Stroke (S24.006). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202997.Peer-Reviewed Original Research
2021
Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome
Nogueira R, Aries M, Minhas J, Petersen N, Xiong L, Kainerstorfer J, Castro P. Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome. Cerebrovascular And Brain Metabolism Reviews 2021, 42: 430-453. PMID: 34515547, PMCID: PMC8985432, DOI: 10.1177/0271678x211045222.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationAcute phaseClinical outcomesCerebral autoregulationAcute ischemic strokeCerebral hemodynamic parametersPotential therapeutic targetCerebrovascular disease statesAcute strokeIschemic strokeStroke onsetCerebral perfusionCerebral circulationIntracerebral hemorrhageHigh morbidityHemodynamic parametersIndividual patientsPerfusion interventionsNew therapiesTherapeutic targetHemodynamic aspectsPatientsAdditional treatmentDisease statesRelevant studies
2018
Safety Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage (P4.033)
Chu S, Sommaruga S, Hwang D, Dearborn J, Sansing L, Cord B, Samarth G, Petersen N, Gilmore E, Schindler J, Matouk C, Sheth K, Falcone G. Safety Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage (P4.033). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p4.033.Peer-Reviewed Original Research
2015
Dynamic Cerebral Autoregulation Is Transiently Impaired for One Week after Large-Vessel Acute Ischemic Stroke
Petersen NH, Ortega-Gutierrez S, Reccius A, Masurkar A, Huang A, Marshall RS. Dynamic Cerebral Autoregulation Is Transiently Impaired for One Week after Large-Vessel Acute Ischemic Stroke. Cerebrovascular Diseases 2015, 39: 144-150. PMID: 25661277, PMCID: PMC4754197, DOI: 10.1159/000368595.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationLarge-vessel ischemic strokeUnaffected hemisphereAffected hemisphereIschemic strokeCerebral autoregulationBlood pressureAcute large-vessel ischemic strokeLarge vessel acute ischemic strokeAcute blood pressure managementMiddle cerebral artery territoryAcute ischemic strokeBlood pressure managementCerebral blood flowBlood flow velocityDay strokePoor autoregulationAcute strokeArtery territoryArterial catheterTranscranial DopplerAffected sideUnaffected sideControl subjectsHealthy controls
2012
Dynamic Cerebral Autoregulation Is Transiently Impaired after Large-Vessel Acute Ischemic Stroke (S19.002)
Petersen N, Ortega-Gutierrez S, Reccius A, Huang A, Masurkar A, Marshall R. Dynamic Cerebral Autoregulation Is Transiently Impaired after Large-Vessel Acute Ischemic Stroke (S19.002). Neurology 2012, 78: s19.002-s19.002. DOI: 10.1212/wnl.78.1_meetingabstracts.s19.002.Peer-Reviewed Original Research