2015
Influence of genetic background and oxidative stress response on risk of mandibular osteoradionecrosis after radiotherapy of head and neck cancer
Danielsson D, Brehwens K, Halle M, Marczyk M, Sollazzo A, Polanska J, Munck-Wikland E, Wojcik A, Haghdoost S. Influence of genetic background and oxidative stress response on risk of mandibular osteoradionecrosis after radiotherapy of head and neck cancer. Head & Neck 2015, 38: 387-393. PMID: 25352150, DOI: 10.1002/hed.23903.Peer-Reviewed Original ResearchConceptsRadiotherapy of headGlutathione S-transferase P1Mandibular osteoradionecrosisNeck cancerCohort of patientsIndividual radiosensitivitySingle nucleotide polymorphismsRadiation-induced oxidative stressDihydro-2'-deoxyguanosine levelsNeck radiotherapy treatmentConcomitant brachytherapyOxidative stress responseSevere complicationsPatient cohortOsteoradionecrosisSNP rs1695Multivariate analysisTissue damageHealthy tissue damagePatientsOxidative stressRadiotherapy treatmentRadiotherapyCohortBiomarker analysis
2014
Radiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients
Jelonek K, Pietrowska M, Ros M, Zagdanski A, Suchwalko A, Polanska J, Marczyk M, Rutkowski T, Skladowski K, Clench MR, Widlak P. Radiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients. International Journal Of Molecular Sciences 2014, 15: 6609-6624. PMID: 24747595, PMCID: PMC4013650, DOI: 10.3390/ijms15046609.Peer-Reviewed Original ResearchConceptsSerum lipidomeConformal radiotherapyMedium dosesEnd of radiotherapyNeck cancer patientsRadiation-induced changesWhole patient bodyBody responsePost-treatment samplesDoses of radiationBlood levelsCancer patientsNeck cancerBlood samplesRadiotherapyNormal tissuesPatientsDosesCancer radiotherapyLipidomePatient's bodyTreatment samplesTissueLipid extractsCancer
2011
Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: association with tumor progression.
Pietrowska M, Polańska J, Suwiński R, Wideł M, Rutkowski T, Marczyk M, Domińczyk I, Ponge L, Marczak L, Polański A, Widłak P. Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: association with tumor progression. International Journal Of Oncology 2011, 40: 148-56. PMID: 21894432, DOI: 10.3892/ijo.2011.1186.Peer-Reviewed Original ResearchConceptsLung cancer samplesCancer samplesHealthy donorsSerum proteomeNon-small cell lung cancerNeck squamous cell cancerSquamous cell cancerCell lung cancerAdvanced cancer casesSera of patientsColorectal cancer samplesCancer signaturesInter-group analysisPeptide signaturesCell cancerClinical stageColorectal cancerCancer patientsLung cancerNeck cancerColorectal adenocarcinomaCancer casesSerum amyloidHealthy volunteersBlood samplesAssociation between plasma proteome profiles analysed by mass spectrometry, a lymphocyte-based DNA-break repair assay and radiotherapy-induced acute mucosal reaction in head and neck cancer patients
Pietrowska M, Polańska J, Walaszczyk A, Wygoda A, Rutkowski T, Składowski K, Marczak Ł, Stobiecki M, Marczyk M, Polański A, Widłak P. Association between plasma proteome profiles analysed by mass spectrometry, a lymphocyte-based DNA-break repair assay and radiotherapy-induced acute mucosal reaction in head and neck cancer patients. International Journal Of Radiation Biology 2011, 87: 711-719. PMID: 21351848, DOI: 10.3109/09553002.2011.556174.Peer-Reviewed Original ResearchConceptsAcute mucosal reactionsAcute reactionsMucosal reactionsNeck cancerPlasma proteomeNeck cancer patientsPlasma proteome profilesDefinitive radiotherapyCancer patientsPredictive markerHealthy donorsBlood samplesHealthy individualsPatientsRadiotherapyPlasma samplesComet assayLymphocytesCancerMaximal intensityMarkersProteome profiles