2023
Short- and long-term effects of radiation exposure at low dose and low dose rate in normal human VH10 fibroblasts
Akuwudike P, López-Riego M, Marczyk M, Kocibalova Z, Brückner F, Polańska J, Wojcik A, Lundholm L. Short- and long-term effects of radiation exposure at low dose and low dose rate in normal human VH10 fibroblasts. Frontiers In Public Health 2023, 11: 1297942. PMID: 38162630, PMCID: PMC10755029, DOI: 10.3389/fpubh.2023.1297942.Peer-Reviewed Original ResearchConceptsLong-term effectsLow dosesDose-rate effectiveness factorLow dose rateSignificant early effectsColony forming assaysDays post irradiationEarly time pointsPooled cohortValidation cohortStrong cytotoxic effectEpidemiological dataLow doseGy/minCell growth curveSample cohortCohortThird cohortCell viability assaysRadiation exposureEarly effectsTime pointsCytotoxic effectsGene expression changesConsistent upregulation
2016
Serum mass profile signature as a biomarker of early lung cancer
Widlak P, Pietrowska M, Polanska J, Marczyk M, Ros-Mazurczyk M, Dziadziuszko R, Jassem J, Rzyman W. Serum mass profile signature as a biomarker of early lung cancer. Lung Cancer 2016, 99: 46-52. PMID: 27565913, DOI: 10.1016/j.lungcan.2016.06.011.Peer-Reviewed Original ResearchConceptsEarly lung cancerLung cancerNegative predictive valuePredictive valueComputed tomographyEarly-stage lung cancerLow-dose computed tomographyIndeterminate pulmonary nodulesStage lung cancerPotential clinical usefulnessPositive predictive valueValidation cohortHealthy controlsClinical usefulnessDiscovery cohortBlood samplesIndependent cohortWeight serum fractionsPulmonary nodulesIndependent sample setCancerPatientsHealthy participantsMolecular biomarkersCohort