2021
Importance of SNP Dependency Correction and Association Integration for Gene Set Analysis in Genome-Wide Association Studies
Marczyk M, Macioszek A, Tobiasz J, Polanska J, Zyla J. Importance of SNP Dependency Correction and Association Integration for Gene Set Analysis in Genome-Wide Association Studies. Frontiers In Genetics 2021, 12: 767358. PMID: 34956320, PMCID: PMC8696167, DOI: 10.3389/fgene.2021.767358.Peer-Reviewed Original ResearchGenome-wide association studiesOver-Representation AnalysisSingle nucleotide polymorphismsMeta-Analysis Gene-set EnrichmentSame geneTypical genome-wide association studyEnrichment analysisAssociation studiesGene-set analysisLD correctionGene set enrichmentGene expression dataGSEA-SNPCancer Genome Atlas (TCGA) databaseRelevant single nucleotide polymorphismsTranscriptomic levelGene levelExpression dataVariant associationsNonrandom associationGenesAssociation of SNPsMore lociAtlas databaseBreast cancer samples
2020
Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer
Drobin K, Marczyk M, Halle M, Danielsson D, Papiez A, Sangsuwan T, Bendes A, Hong MG, Qundos U, Harms-Ringdahl M, Wersäll P, Polanska J, Schwenk JM, Haghdoost S. Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer. Cancers 2020, 12: 753. PMID: 32235817, PMCID: PMC7140105, DOI: 10.3390/cancers12030753.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsCancer patientsRadiosensitive patientsProteomic dataDNA repairSNP variantsRadiation-induced toxicityNeck cancer patientsLong-term survivalPredictors of radiosensitivityNucleotide polymorphismsProteinAdverse health effectsPlasma proteomicsGrowth capacityNeck cancerPredictive proteinsBreast cancerImmune responsePatient radiosensitivityPatientsStudy setDNA genotypingMolecular profilingNormal tissues
2015
Influence of genetic background and oxidative stress response on risk of mandibular osteoradionecrosis after radiotherapy of head and neck cancer
Danielsson D, Brehwens K, Halle M, Marczyk M, Sollazzo A, Polanska J, Munck-Wikland E, Wojcik A, Haghdoost S. Influence of genetic background and oxidative stress response on risk of mandibular osteoradionecrosis after radiotherapy of head and neck cancer. Head & Neck 2015, 38: 387-393. PMID: 25352150, DOI: 10.1002/hed.23903.Peer-Reviewed Original ResearchConceptsRadiotherapy of headGlutathione S-transferase P1Mandibular osteoradionecrosisNeck cancerCohort of patientsIndividual radiosensitivitySingle nucleotide polymorphismsRadiation-induced oxidative stressDihydro-2'-deoxyguanosine levelsNeck radiotherapy treatmentConcomitant brachytherapyOxidative stress responseSevere complicationsPatient cohortOsteoradionecrosisSNP rs1695Multivariate analysisTissue damageHealthy tissue damagePatientsOxidative stressRadiotherapy treatmentRadiotherapyCohortBiomarker analysis