Immune activation during Paenibacillus brain infection in African infants with frequent cytomegalovirus co-infection
Isaacs A, Morton S, Movassagh M, Zhang Q, Hehnly C, Zhang L, Morales D, Sinnar S, Ericson J, Mbabazi-Kabachelor E, Ssenyonga P, Onen J, Mulondo R, Hornig M, Warf B, Broach J, Townsend R, Limbrick D, Paulson J, Schiff S. Immune activation during Paenibacillus brain infection in African infants with frequent cytomegalovirus co-infection. IScience 2021, 24: 102351. PMID: 33912816, PMCID: PMC8065213, DOI: 10.1016/j.isci.2021.102351.Peer-Reviewed Original ResearchNeonatal sepsisBrain infectionImmune activationInnate immune system responseRisk of hydrocephalusDominant bacterial pathogenHost immune responsePlatelet-activating factorImmune system responseOxidative stress reactionSecondary sequelaeAdjunctive treatmentImmune response networkNeutrophil activityIL-12Hydrocephalic infantsAfrican infantsIL-13IL-4JAK/STAT pathwayAntigen-presenting complexImmune responseHydrocephalusPotential targetNeuroinflammation