2016
Breast cancer and social environment: getting by with a little help from our friends
Hinzey A, Gaudier-Diaz M, Lustberg M, DeVries A. Breast cancer and social environment: getting by with a little help from our friends. Breast Cancer Research 2016, 18: 54. PMID: 27225892, PMCID: PMC4881170, DOI: 10.1186/s13058-016-0700-x.Peer-Reviewed Original ResearchConceptsTumor growthBreast cancerBreast cancer survivorsBreast cancer patientsIdentification of patientsCancer-related mortalityMammary tumor growthBreast cancer progressionBasic science literatureInadequate social supportTherapeutic complementCancer survivorsPoor outcomeCancer patientsTumor progressionProtective pathwaysContemporary treatmentDetrimental pathwaysCancer progressionTargeted disruptionUnderlying physiological mechanismsSocial isolationPatientsCancerSocial support
2014
CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth
Mathsyaraja H, Thies K, Taffany D, Deighan C, Liu T, Yu L, Fernandez S, Shapiro C, Otero J, Timmers C, Lustberg M, Chalmers J, Leone G, Ostrowski M. CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth. Oncogene 2014, 34: 3651-3661. PMID: 25241894, PMCID: PMC4369473, DOI: 10.1038/onc.2014.294.Peer-Reviewed Original ResearchConceptsTumor-infiltrating myeloid cellsMetastatic tumor growthMyeloid cellsMiR-21Breast cancerTumor growthHuman metastatic breast cancerMetastatic tumor burdenMetastatic breast cancerPro-tumor functionsAnti-angiogenic genesAttractive therapeutic targetTumor cell proliferationPro-angiogenic propertiesMature myeloid cellsTumor burdenMonocytes correlatesPoor prognosisMelanoma metastasesMouse modelTherapeutic targetSolid tumorsOncogenic roleSurvival rateTherapeutic efficacy