2017
Multispectral Imaging Analysis of Circulating Tumor Cells in Negatively Enriched Peripheral Blood Samples
Miller B, Lustberg M, Summers T, Chalmers J. Multispectral Imaging Analysis of Circulating Tumor Cells in Negatively Enriched Peripheral Blood Samples. Methods In Molecular Biology 2017, 1634: 219-234. PMID: 28819855, DOI: 10.1007/978-1-4939-7144-2_19.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBreast NeoplasmsCarbocyaninesCell CountCell Line, TumorEpithelial Cell Adhesion MoleculeFemaleFluorescent DyesHumansHydrazinesImage Processing, Computer-AssistedIndolesKeratinsLeukocyte Common AntigensLeukocytes, MononuclearLiquid CrystalsNeoplastic Cells, CirculatingOptical ImagingSoftwareSuccinimidesConceptsPeripheral blood samplesBlood samplesPeripheral bloodTumor cellsLiquid biopsyUseful predictive markerSolid tumor malignanciesVariety of disordersUndefined cell typesLow EpCAM expressionSpecific cell surface markersCell surface markersVariety of biomarkersPredictive markerTherapeutic responseSolid tumorsPositive selection technologyDisease statusTumor malignancyFuture validation studiesEpCAM expressionSurface markersMultispectral imaging analysisProtein levelsExact role
2012
Circulating CD68 positive (+) leukocytes in blood samples from patients (pts) with breast cancer (BC).
Lustberg M, Miller B, Wu Y, Xue W, Deighan C, Carothers S, Berger M, Shapiro C, Chalmers J. Circulating CD68 positive (+) leukocytes in blood samples from patients (pts) with breast cancer (BC). Journal Of Clinical Oncology 2012, 30: 172-172. DOI: 10.1200/jco.2012.30.27_suppl.172.Peer-Reviewed Original ResearchBlood samplesBreast cancerLeukocyte populationsPeripheral blood leukocyte populationsNegative depletionAdvanced breast cancerMultiparameter flow cytometry analysisVenous blood samplesBlood leukocyte populationsPrimary breast tumorsMacrophages/monocytesProgression of diseaseBreast tumor stromaCell surface markersAdditional phenotypic characterizationFlow cytometry analysisPositive leukocytesBC patientsPeripheral bloodPredictive markerPoor responseCD 68Such tumorsPatient's stageT cellsAssessment of γ-H2AX levels in circulating tumor cells from patients receiving chemotherapy
Garcia-Villa A, Balasubramanian P, Miller B, Lustberg M, Ramaswamy B, Chalmers J. Assessment of γ-H2AX levels in circulating tumor cells from patients receiving chemotherapy. Frontiers In Oncology 2012, 2: 128. PMID: 23112954, PMCID: PMC3480704, DOI: 10.3389/fonc.2012.00128.Peer-Reviewed Original ResearchStage IV breast cancerTumor cellsBreast cancer patientsPlatinum-based therapySolid tumor malignanciesPotential of CTCsSurface markers CD45Γ-H2AXDNA-damaging therapiesΓ-H2AX levelsPlatinum therapyPeripheral bloodCancer patientsPredictive markerPatient outcomesPrognostic markerBreast cancerΓ-H2AX stainingPatient's conditionTumor malignancyTherapyNegative depletionLiquid biopsyStaining patternCell apoptosis