Serial circulating tumor DNA samples from patients with metastatic breast cancer and BRCA1/2 mutations.
Collier K, Tallman D, Weber Z, Haynam M, Adams E, Jenison J, Asad S, Lustberg M, Cherian M, Ramaswamy B, Sardesai S, Williams N, Wesolowski R, VanDeusen J, Gatti-Mays M, Pariser A, Mortazavi A, Stover D. Serial circulating tumor DNA samples from patients with metastatic breast cancer and BRCA1/2 mutations. Journal Of Clinical Oncology 2021, 39: 1025-1025. DOI: 10.1200/jco.2021.39.15_suppl.1025.Peer-Reviewed Original ResearchMetastatic breast cancerTargeted panel sequencingPlatinum chemotherapySomatic copy number alterationsPARP inhibitorsBreast cancerPlasma samplesSerial ctDNA samplesHormone receptor statusNon-invasive evaluationPass whole genome sequencingDNA damage repair genesLast time pointTumor DNA samplesReceptor statusHR statusControl cohortLast timepointBRCA1/2 mutationsSomatic BRCA1Blood samplesCancer-related genesCtDNA samplesSerial samplesTumor fraction