2024
Feasibility and metabolic outcomes of a well-formulated ketogenic diet as an adjuvant therapeutic intervention for women with stage IV metastatic breast cancer: The Keto-CARE trial
Buga A, Harper D, Sapper T, Hyde P, Fell B, Dickerson R, Stoner J, Kackley M, Crabtree C, Decker D, Robinson B, Krystal G, Binzel K, Lustberg M, Volek J. Feasibility and metabolic outcomes of a well-formulated ketogenic diet as an adjuvant therapeutic intervention for women with stage IV metastatic breast cancer: The Keto-CARE trial. PLOS ONE 2024, 19: e0296523. PMID: 38166036, PMCID: PMC10760925, DOI: 10.1371/journal.pone.0296523.Peer-Reviewed Original ResearchConceptsMetastatic breast cancerStage IV metastatic breast cancerKetogenic dietInsulin resistanceNutritional ketosisPlasma insulinBreast cancerBody compositionAdjuvant therapeutic interventionsMetabolic outcomesCancer patientsPlasma glucoseMetabolic effectsBody fatShort-term studiesBody weightPleiotropic mechanismsTherapeutic interventionsConsistent bloodPhase IMonthsWomenCancerAd libitumChemotherapy
2017
Pleiotropic effects of nutritional ketosis: Conceptual framework for keto-adaptation as a breast cancer therapy
Hyde P, Lustberg M, Miller V, LaFountain R, Volek J. Pleiotropic effects of nutritional ketosis: Conceptual framework for keto-adaptation as a breast cancer therapy. Cancer Treatment And Research Communications 2017, 12: 32-39. DOI: 10.1016/j.ctarc.2017.06.001.Peer-Reviewed Original ResearchNutritional ketosisBreast cancerHead/neck cancerWhole-body fatty acid oxidationDietary carbohydrate restrictionDietary intervention studyBreast cancer therapyOptimal nutrition strategyPositive health outcomesBreast cancer pathologyFatty acid oxidationCarbohydrate restrictionCancer survivorsInsulin resistanceInsulin receptor activationNeck cancerTreatment modalitiesInsulin concentrationsStandalone therapyTherapeutic approachesHeterogeneous diseaseGlioblastoma multiformeCancer modelHealth outcomesIntervention studies