2024
Low Sucrose Diets Protect Long-Term Memory and EPA & DHA Enriched Diets Alter Insulin Resistance in a Mouse Model of Chemotherapy
Ormiston K, Fitzgerald J, Andridge R, Lustberg M, DeVries A, Orchard T. Low Sucrose Diets Protect Long-Term Memory and EPA & DHA Enriched Diets Alter Insulin Resistance in a Mouse Model of Chemotherapy. Nutrition Research 2024 DOI: 10.1016/j.nutres.2024.09.004.Peer-Reviewed Original ResearchLiver lipid contentMouse model of chemotherapyLipid contentBody weightLong-term memorySucrose dietLow-sucrose dietDocosahexaenoic acidInsulin resistanceChemotherapy-related cognitive impairmentMouse modelEffects of EPA+DHADoxorubicin-based chemotherapyFemale C57BL/6 miceImpact of chemotherapyAltered insulin resistanceNegatively impacts quality of lifeInsulin resistance scoreDietResistance scoreLower sucrose consumptionEPA+DHARandomized to 1Affective side effectsEicosapentaenoic acid + docosahexaenoic acid
2022
Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model
Young N, Hampton J, Sharma J, Jablonski K, DeVries C, Bratasz A, Wu L, Lustberg M, Reinbolt R, Jarjour W. Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model. Pharmaceuticals 2022, 15: 1578. PMID: 36559029, PMCID: PMC9785754, DOI: 10.3390/ph15121578.Peer-Reviewed Original ResearchAI treatmentFemale BALB/cHalf of patientsPositive breast cancerPro-inflammatory cytokines analysisFuture interventional strategiesNovel mouse modelBALB/cPhysiological estrogen levelsNovel animal modelMusculoskeletal inflammationSerum cytokinesEstrogen deficiencyCytokine analysisEstrogen combinationEstrogen levelsEstrogen productionAromatase inhibitorsBreast cancerHuman PBMCsInterventional strategiesMouse modelAnimal modelsNFκB activationBioluminescent imaging
2021
Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy
Ormiston K, Gaudier-Diaz MM, TinKai T, Fitzgerald J, Cole RM, Andridge R, Lustberg M, DeVries AC, Orchard T. Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy. Nutritional Neuroscience 2021, 25: 2650-2658. PMID: 34772330, PMCID: PMC9095756, DOI: 10.1080/1028415x.2021.1998296.Peer-Reviewed Original ResearchConceptsAlpha-linolenic acidDietary alpha-linolenic acidBrain PUFAsMouse modelDocosahexaenoic acidEicosapentaenoic acidLiver PUFABrain nOmega-3 fatty acidsChemotherapy-treated miceHigh ALA dietLow ALA intakeBrain fatty acidsUseful surrogate markerFatty acidsLiver docosahexaenoic acidToxic side effectsLiver fatty acidALA intakeNeurotrophic markersALA dietDHA dietSurrogate markerLower brainSide effects
2020
Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice
Huang KM, Leblanc AF, Uddin ME, Kim JY, Chen M, Eisenmann ED, Gibson A, Li Y, Hong KW, DiGiacomo D, Xia S, Alberti P, Chiorazzi A, Housley SN, Cope TC, Sprowl JA, Wang J, Loprinzi CL, Noonan A, Lustberg M, Cavaletti G, Pabla N, Hu S, Sparreboom A. Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice. Journal Of Clinical Investigation 2020, 130: 4601-4606. PMID: 32484793, PMCID: PMC7456253, DOI: 10.1172/jci136796.Peer-Reviewed Original ResearchConceptsOrganic cation transporter 2Peripheral neurotoxicityColorectal cancerOxaliplatin-induced peripheral neurotoxicityOxaliplatin-containing therapyOxaliplatin-induced neurotoxicitySatellite glial cellsOxaliplatin neurotoxicityChronic formCancer patientsGlial cellsPreclinical modelsPreventive strategiesMouse modelPharmacological approachesPharmacological targetingTranslational significanceNeurotoxicityTransporter 2PatientsUptake transportersCancerAnticancer drugsCandidate transportersSolute carriersEffects of Omega-3 Fatty Acids on Brain Fatty Acids and Associations with Glucose Metabolism and Anxiety-Like Behavior in an Ovariectomized Mouse Model of Chemotherapy
Ormiston K, Phuwamongkolwiwat-Chu P, Fitzgerald J, Tinkai T, Lustberg M, DeVries A, Andridge R, Orchard T. Effects of Omega-3 Fatty Acids on Brain Fatty Acids and Associations with Glucose Metabolism and Anxiety-Like Behavior in an Ovariectomized Mouse Model of Chemotherapy. Current Developments In Nutrition 2020, 4: nzaa057_044. PMCID: PMC7257389, DOI: 10.1093/cdn/nzaa057_044.Peer-Reviewed Original ResearchAnxiety-like behaviorBrain AADietary eicosapentaenoic acidHigh-sucrose dietDHA dietSerum insulinDocosahexaenoic acidOmega-3Low omega-3Eicosapentaenoic acidChemotherapy injectionsInsulin resistanceMouse modelGlucose metabolismSucrose dietOmega-3 fatty acidsBrain fatty acidsHomeostatic model assessmentLower HOMA-IRDiet fed miceHigher serum insulinOvariectomized mouse modelFatty acidsOvariectomized C57BL/6 miceMore anxiety-like behaviorDifferential Contribution of Neuronal Uptake Transporters to Oxaliplatin Peripheral Neurotoxicity
Huang K, Leblanc A, Alberti P, Sprowl J, Wang J, Lustberg M, Cavaletti G, Hu S, Sparreboom A. Differential Contribution of Neuronal Uptake Transporters to Oxaliplatin Peripheral Neurotoxicity. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.03083.Peer-Reviewed Original ResearchDorsal root gangliaPeripheral neurotoxicityColorectal cancerOxaliplatin-induced peripheral neurotoxicityVon Frey hair testChronic peripheral neurotoxicityOxaliplatin-induced neurotoxicityVivo cultureColorectal cancer cellsWild-type ratsEx vivo cultureOxaliplatin therapyAfford neuroprotectionObserved neuroprotectionNeurological injuryRoot gangliaOxaliplatin accumulationSystemic clearanceConventional chemotherapyGlial cellsPreclinical modelsSprague-DawleySensory neuronsMouse modelSide effects
2019
An omega-3 Fatty Acid Enriched Diet Reduces Anxiety-like Behavior While High Dietary Sucrose During Chemotherapy Increases Anxiety-like Behavior in Mice (P14-023-19)
Ormiston K, Orchard T, DeVries A, Phuwamongkolwiwat P, Li J, Andridge R, Fitzgerald J, Tinkai T, Lustberg M. An omega-3 Fatty Acid Enriched Diet Reduces Anxiety-like Behavior While High Dietary Sucrose During Chemotherapy Increases Anxiety-like Behavior in Mice (P14-023-19). Current Developments In Nutrition 2019, 3: nzz052.p14-023-19. PMCID: PMC6573952, DOI: 10.1093/cdn/nzz052.p14-023-19.Peer-Reviewed Original ResearchAnxiety-like behaviorDocosahexaenoic acidIncreases Anxiety-Like BehaviorWeeks of dietBreast cancer patientsAssociation of cytokinesNumber of marblesOvariectomized C57BL/6 miceLess anxiety-like behaviorSignificant differencesSymptoms of anxietyChemotherapy injectionsChemotherapy groupDHA groupHealthy womenFatty acidsMice fedSaline groupC57BL/6 miceInflammatory cytokinesCancer patientsChemotherapy increasesInterleukin-6Results TwentyMouse model
2018
Low Sucrose, Omega-3 Enriched Diet Has Region-Specific Effects on Neuroinflammation and Synaptic Function Markers in a Mouse Model of Doxorubicin-Based Chemotherapy
Orchard T, Gaudier-Diaz M, Phuwamongkolwiwat-Chu P, Andridge R, Lustberg M, Bomser J, Cole R, Belury M, DeVries A. Low Sucrose, Omega-3 Enriched Diet Has Region-Specific Effects on Neuroinflammation and Synaptic Function Markers in a Mouse Model of Doxorubicin-Based Chemotherapy. Nutrients 2018, 10: 2004. PMID: 30567351, PMCID: PMC6316589, DOI: 10.3390/nu10122004.Peer-Reviewed Original ResearchConceptsDHA dietSynaptic damageSecond injectionPro-inflammatory cytokines IL-1βChemotherapy-treated miceKC/GROCytokines IL-1βLong-term brainLow-sucrose dietTwo-injection regimenQuality of lifeSpecific brain regionsBrain DHARegion-specific effectsC57BL/6 miceCancer survivorsFunction markersIL-1βIL-6Synaptic markersIL-5Mouse modelNeuroinflammationSucrose dietChemotherapyA Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer
Borniger J, Walker W, Surbhi, Emmer K, Zhang N, Zalenski A, Muscarella S, Fitzgerald J, Smith A, Braam C, TinKai T, Magalang U, Lustberg M, Nelson R, DeVries A. A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer. Cell Metabolism 2018, 28: 118-129.e5. PMID: 29805100, PMCID: PMC6031468, DOI: 10.1016/j.cmet.2018.04.021.Peer-Reviewed Original ResearchConceptsTumor-bearing miceSleep abnormalitiesMetabolic abnormalitiesIL-6Non-metastatic breast cancerHypocretin/orexin neuronsHypothalamic hypocretin/orexin neuronsPeripheral sympathetic denervationSerum leptin concentrationsTumor-induced increaseTumor-induced changesEnhanced sleep qualityHypocretin/orexinPeripheral inflammationSympathetic denervationExogenous ghrelinOrexin neuronsLeptin concentrationsInterleukin-6Serum glucoseMammary cancerBreast cancerSleep qualityMouse modelCentral neuromodulators
2015
Effects of Sucrose and Omega-3 Fatty Acids on Chemotherapy-Induced Neuroinflammation in a Mouse Model of Breast Cancer
Gaudier-Diaz M, Lustberg M, Cole R, Belury M, DeVries A, Orchard T. Effects of Sucrose and Omega-3 Fatty Acids on Chemotherapy-Induced Neuroinflammation in a Mouse Model of Breast Cancer. Journal Of The Academy Of Nutrition And Dietetics 2015, 115: a25. DOI: 10.1016/j.jand.2015.06.081.Peer-Reviewed Original Research
2014
CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth
Mathsyaraja H, Thies K, Taffany D, Deighan C, Liu T, Yu L, Fernandez S, Shapiro C, Otero J, Timmers C, Lustberg M, Chalmers J, Leone G, Ostrowski M. CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth. Oncogene 2014, 34: 3651-3661. PMID: 25241894, PMCID: PMC4369473, DOI: 10.1038/onc.2014.294.Peer-Reviewed Original ResearchConceptsTumor-infiltrating myeloid cellsMetastatic tumor growthMyeloid cellsMiR-21Breast cancerTumor growthHuman metastatic breast cancerMetastatic tumor burdenMetastatic breast cancerPro-tumor functionsAnti-angiogenic genesAttractive therapeutic targetTumor cell proliferationPro-angiogenic propertiesMature myeloid cellsTumor burdenMonocytes correlatesPoor prognosisMelanoma metastasesMouse modelTherapeutic targetSolid tumorsOncogenic roleSurvival rateTherapeutic efficacy