2010
Epigenetic Therapy in Breast Cancer
Lustberg M, Ramaswamy B. Epigenetic Therapy in Breast Cancer. Current Breast Cancer Reports 2010, 3: 34-43. PMID: 23097683, PMCID: PMC3477864, DOI: 10.1007/s12609-010-0034-0.Peer-Reviewed Original ResearchEpigenetic changesHistone deacetylase inhibitorsMajor epigenetic changesNucleosome remodelingHistone modificationsEpigenetic regulationEpigenetic mechanismsDNA methylationGene sequencesEpigenetic therapyGene expressionDemethylating agentDeacetylase inhibitorsMultistep processBreast cancerEpigeneticsBreast carcinogenesisGenesMethylationSystemic therapyClinical trialsEffective therapyReversible processRegulationSingle agent
2009
Epigenetic targeting in breast cancer: therapeutic impact and future direction.
Lustberg M, Ramaswamy B. Epigenetic targeting in breast cancer: therapeutic impact and future direction. Drug News & Perspectives 2009, 22: 369-81. PMID: 19890494, PMCID: PMC3658161, DOI: 10.1358/dnp.2009.22.7.1405072.Peer-Reviewed Original ResearchConceptsEpigenetic changesHistone modificationsHistone deacetylase inhibitorsGene expressionMajor epigenetic changesHeritable changesRepressor complexDNA methylationGene sequencesEpigenetic targetingDeacetylase inhibitorsMultistep processMethylationExpressionEpigeneticsBreast carcinogenesisGenesReversible processAntiapoptosisNovel therapiesSequenceInvasionProliferationTargetingBreast cancer