2024
Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice
Ormiston K, Melink Z, Andridge R, Lustberg M, DeVries A, Murphy K, Emmers K, Ziouzenkova O, Belury M, Orchard T. Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice. Brain Behavior And Immunity 2024, 123: 370-382. PMID: 39313165, DOI: 10.1016/j.bbi.2024.09.021.Peer-Reviewed Original ResearchHOMA-IRChemotherapy-related cognitive impairmentHigh-fatDietary eicosapentaenoic acidDocosahexaenoic acidBlood-brain barrier regulationDoxorubicin-based chemotherapyFemale C57BL/6 miceLF groupEicosapentaenoic acidBody fat lossLow-fat (LFHF dietNeuroinflammatory gene expressionLipid metabolismMultiple genesReduction of oxidative stressAlterations of glucoseFat (LFHigh-fat dietGene expressionOvariectomized miceC57BL/6 miceChemotherapy agentsBreast cancer
2010
Epigenetic Therapy in Breast Cancer
Lustberg M, Ramaswamy B. Epigenetic Therapy in Breast Cancer. Current Breast Cancer Reports 2010, 3: 34-43. PMID: 23097683, PMCID: PMC3477864, DOI: 10.1007/s12609-010-0034-0.Peer-Reviewed Original ResearchEpigenetic changesHistone deacetylase inhibitorsMajor epigenetic changesNucleosome remodelingHistone modificationsEpigenetic regulationEpigenetic mechanismsDNA methylationGene sequencesEpigenetic therapyGene expressionDemethylating agentDeacetylase inhibitorsMultistep processBreast cancerEpigeneticsBreast carcinogenesisGenesMethylationSystemic therapyClinical trialsEffective therapyReversible processRegulationSingle agent
2009
Epigenetic targeting in breast cancer: therapeutic impact and future direction.
Lustberg M, Ramaswamy B. Epigenetic targeting in breast cancer: therapeutic impact and future direction. Drug News & Perspectives 2009, 22: 369-81. PMID: 19890494, PMCID: PMC3658161, DOI: 10.1358/dnp.2009.22.7.1405072.Peer-Reviewed Original ResearchConceptsEpigenetic changesHistone modificationsHistone deacetylase inhibitorsGene expressionMajor epigenetic changesHeritable changesRepressor complexDNA methylationGene sequencesEpigenetic targetingDeacetylase inhibitorsMultistep processMethylationExpressionEpigeneticsBreast carcinogenesisGenesReversible processAntiapoptosisNovel therapiesSequenceInvasionProliferationTargetingBreast cancer