RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications
Suárez-Fariñas M, Ungar B, da Rosa J, Ewald DA, Rozenblit M, Gonzalez J, Xu H, Zheng X, Peng X, Estrada YD, Dillon SR, Krueger JG, Guttman-Yassky E. RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications. Journal Of Allergy And Clinical Immunology 2015, 135: 1218-1227. PMID: 25840722, DOI: 10.1016/j.jaci.2015.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultComputational BiologyDermatitis, AtopicFemaleGene Expression ProfilingHumansInterleukin-1MaleMembrane GlycoproteinsMiddle AgedMolecular Sequence AnnotationReceptors, ImmunologicReproducibility of ResultsSequence Analysis, RNASignal TransductionSkinTranscriptomeTriggering Receptor Expressed on Myeloid Cells-1ConceptsAtopic dermatitisAD transcriptomeNonlesional skinMyeloid cells 1 (TREM1) signalingUnderstanding of ADTREM-1 pathwayRT-PCRSevere atopic dermatitisIL-36 cytokinesInfection-related inflammationNovel therapeutic targetPotential therapeutic implicationsAD-related genesNovel disease mechanismsTREM-1Real-time PCRAdaptive immunityAD phenotypeTherapeutic implicationsTherapeutic targetNext-generation RNA sequencingDisease pathologyGenomic profilingSame cohortDisease transcriptome