2024
Weight Nadir and Long-Term Weight Outcomes After Laparoscopic Sleeve Gastrectomy in a Diverse Cohort of Adolescents and Young Adults
Hornick M, Chao G, Ying L, Nadzam G, Duffy A, Ghiassi S, Graetz E, Gibbs K, Morton J. Weight Nadir and Long-Term Weight Outcomes After Laparoscopic Sleeve Gastrectomy in a Diverse Cohort of Adolescents and Young Adults. Obesity Surgery 2024, 34: 2965-2973. PMID: 38935262, DOI: 10.1007/s11695-024-07374-3.Peer-Reviewed Original ResearchPreoperative weightSleeve gastrectomyWeight nadirWeight outcomesIntroductionLaparoscopic sleeve gastrectomyLaparoscopic sleeve gastrectomyGroup of patientsWeight loss strategiesYoung adultsDiverse group of patientsCohort of adolescentsLongitudinal weight dataBariatric proceduresFollow-upNon-Hispanic blacksLoss strategiesMedical recordsPatientsTWLLSGWeight dataWeight recurrenceDiverse cohortGastrectomyWeight changeAmerican society for metabolic and bariatric surgery: intra-operative care pathway for minimally invasive Roux-en-Y gastric bypass
Lin H, Baker J, Meister K, Lak K, Martin Del Campo S, Smith A, Needleman B, Nadzam G, Ying L, Varban O, Reyes A, Breckenbridge J, Tabone L, Gentles C, Echeverri C, Jones S, Gould J, Vosburg W, Jones D, Edwards M, Nimeri A, Kindel T, Petrick A. American society for metabolic and bariatric surgery: intra-operative care pathway for minimally invasive Roux-en-Y gastric bypass. Surgery For Obesity And Related Diseases 2024, 20: 895-909. PMID: 39097472, DOI: 10.1016/j.soard.2024.06.002.Peer-Reviewed Original ResearchProlonged length of stay and omission of adjuvant therapy are associated with early mortality after pancreatic adenocarcinoma resection
Ying L, Ilagan-Ying Y, Kunstman J, Peters N, Almeida M, Blackburn H, Ferrucci L, Billingsley K, Khan S, Chhoda A, John N, Salem R, Sharma A, Ahuja N. Prolonged length of stay and omission of adjuvant therapy are associated with early mortality after pancreatic adenocarcinoma resection. Surgical Oncology Insight 2024, 1: 100007. DOI: 10.1016/j.soi.2024.100007.Peer-Reviewed Original ResearchFactors associated with early mortalityCases of pancreatic adenocarcinomaPancreatic adenocarcinoma resectionRisk of early mortalityLength of stayEarly mortalityAdjuvant chemotherapyPancreatic adenocarcinomaChemotherapy utilizationAdenocarcinoma resectionRisk factors associated with early mortalityOmission of adjuvant therapyNon-metastatic pancreatic adenocarcinomaMultivariate Cox regression modelAssociated with early mortalityPost-resection survivalIncreased risk of early mortalityParticipant Use FileProlonged hospital stayProlonged length of stayAdjuvant chemotherapy utilizationDecrease perioperative complicationsCox regression modelsNon-academic centersHospital risk factorsOutcomes of SADI and OAGB Compared to RYGB from the Metabolic and Bariatric Surgery Quality Improvement Program: The North American Experience
Chao G, Canner J, Hamid S, Ying L, Ghiassi S, Schwartz J, Gibbs K. Outcomes of SADI and OAGB Compared to RYGB from the Metabolic and Bariatric Surgery Quality Improvement Program: The North American Experience. Obesity Surgery 2024, 34: 337-346. PMID: 38170422, DOI: 10.1007/s11695-023-07019-x.Peer-Reviewed Original ResearchSleeve gastrectomyQuality Improvement Program databaseBariatric surgery casesImprovement Program databaseHigh complication rateStaple line leakBariatric-metabolic surgerySpecific patient needsDesire of patientsQuality Improvement ProgramBowel obstructionGastric bypassGastrointestinal bleedingComplication rateOAGBProgram databaseSurgery casesRYGBAnastomosis techniqueRobotic casesBetter outcomesPatient needsPatientsLogistic regressionOutcomes
2023
The Degree of Preoperative Hypoalbuminemia Is Associated with Risk of Postoperative Complications in Metabolic and Bariatric Surgery Patients
Ying L, Chao G, Canner J, Graetz E, Ghiassi S, Schwartz J, Zolfaghari E, Schneider E, Gibbs K. The Degree of Preoperative Hypoalbuminemia Is Associated with Risk of Postoperative Complications in Metabolic and Bariatric Surgery Patients. Obesity Surgery 2023, 34: 51-70. PMID: 37994997, DOI: 10.1007/s11695-023-06944-1.Peer-Reviewed Original ResearchConceptsBariatric surgery patientsPostoperative complicationsOdds ratioRevision patientsSurgery patientsRevision surgeryIntensive care unit admissionQuality Improvement Program databaseDegree of hypoalbuminemiaImpact of hypoalbuminemiaPrevalence of hypoalbuminemiaCare unit admissionLaparoscopic sleeve gastrectomyGastric bypass patientsImprovement Program databaseBody mass indexInsulin-dependent diabetesMultivariable logistic regressionAnesthesia classMild hypoalbuminemiaPreoperative hypoalbuminemiaUnit admissionUnplanned intubationPrimary surgerySleeve gastrectomyUtility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms
Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan W, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood L, Iacobuzio-Donahue C, Wolfgang C, Kunstman J, Salem R, Farrell J, Ahuja N. Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms. Clinical Epigenetics 2023, 15: 28. PMID: 36803844, PMCID: PMC9942382, DOI: 10.1186/s13148-023-01429-5.Peer-Reviewed Original ResearchConceptsPapillary mucinous neoplasmMalignant risk stratificationCACNA1G geneRisk stratificationMucinous neoplasmsBiomarker panelBackgroundIntraductal papillary mucinous neoplasmIntraductal papillary mucinous neoplasmEarly detectionPrevious case-control studyHigh-grade dysplasiaCase-control studyPancreatic cancer precursorsReceiver Operating Characteristic (ROC) curve analysisSignificant diagnostic challengeCross-sectional imagingCharacteristic curve analysisOperating Characteristic curve analysisG geneHigh diagnostic specificityPrior validation studiesSignificant procedural riskIPMN tissuesSurgical resectionAdvanced neoplasia
2022
The role of preoperative toxicology screening in patients undergoing bariatric surgery
Chao G, Ying L, Chan S, Alturki N, Aravind P, Thaqi M, Mahmoud A, Morton J. The role of preoperative toxicology screening in patients undergoing bariatric surgery. Surgery For Obesity And Related Diseases 2022, 19: 187-193. PMID: 36443215, DOI: 10.1016/j.soard.2022.10.021.Peer-Reviewed Original ResearchConceptsPreoperative lengthBariatric surgeryToxicology testingWeight lossBariatric surgical populationBody mass indexImportant surgical outcomesAcademic health systemGastric bypassLack of evidenceSurgical populationPostoperative outcomesRetrospective reviewMass indexSurgical outcomesUrine testingPositivity rateMean changePositive testingPatientsNegative testingReadmissionHealth systemChi-squarePositivityS1453 Weight Loss in Bariatric Surgery Patients Treated at a Novel Clinic Incorporating Obesity Medicine for Treatment of Nonalcoholic Fatty Liver Disease
Ilagan-Ying Y, Schwartz A, Park E, Bollinger B, Ying L, Mehal W, Do A. S1453 Weight Loss in Bariatric Surgery Patients Treated at a Novel Clinic Incorporating Obesity Medicine for Treatment of Nonalcoholic Fatty Liver Disease. The American Journal Of Gastroenterology 2022, 117: e1043-e1044. DOI: 10.14309/01.ajg.0000862452.53915.0f.Peer-Reviewed Original ResearchIncreased Mortality in Patients Undergoing Inpatient Endoscopy During the Early COVID-19 Pandemic
Ilagan-Ying YC, Almeida MN, Kahler-Quesada A, Ying L, Hughes ML, Do A, Hung KW. Increased Mortality in Patients Undergoing Inpatient Endoscopy During the Early COVID-19 Pandemic. Digestive Diseases And Sciences 2022, 67: 5053-5062. PMID: 35182250, PMCID: PMC8857390, DOI: 10.1007/s10620-022-07414-x.Peer-Reviewed Original ResearchConceptsInpatient endoscopyCare centerEndoscopic proceduresIntensive care unit admissionAcademic tertiary care centerCare unit admissionProportion of patientsTertiary care centerCoronavirus disease 2019 (COVID-19) pandemicHigher mortality riskDisease 2019 pandemicEarly COVID-19 pandemicICU admissionUnit admissionPatient demographicsUrgent indicationsBlood transfusionFirst waveHigher proportionPatient reluctanceMale genderUrgent proceduresProcedural characteristicsHospital careMost healthcare systems
2021
Methylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer
Ying L, Sharma A, Chhoda A, Ruzgar N, Hasan N, Kwak R, Wolfgang CL, Wang TH, Kunstman JW, Salem RR, Wood LD, Iacobuzio-Donahue C, Schneider EB, Farrell JJ, Ahuja N. Methylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer. Pancreas 2021, 50: 1267-1273. PMID: 34860810, DOI: 10.1097/mpa.0000000000001919.Peer-Reviewed Original ResearchPerforming Bariatric Surgery on Previously COVID+ Patients Is Safe and Effective
Cheung MS, Ying L, Duffy AJ, Ghiassi S, Nadzam G, Roberts KE, Morton JM. Performing Bariatric Surgery on Previously COVID+ Patients Is Safe and Effective. Obesity Surgery 2021, 31: 5082-5084. PMID: 34453312, PMCID: PMC8396140, DOI: 10.1007/s11695-021-05659-5.Peer-Reviewed Original Research
2020
S0101 Clinical and Demographic Predictors of Rapidly Progressive Disease in Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma: Risk Profiling From the National Cancer Database
Ilagan-Ying Y, Ying L, Ferrucci L, Peters N, Blackburn H, Kunstman J, Ahuja N. S0101 Clinical and Demographic Predictors of Rapidly Progressive Disease in Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma: Risk Profiling From the National Cancer Database. The American Journal Of Gastroenterology 2020, 115: s48-s49. DOI: 10.14309/01.ajg.0000702452.53969.ae.Peer-Reviewed Original ResearchS0564 Understanding the Impact of the COVID-19 Pandemic on Inpatient Gastrointestinal Procedures: A Single Center Study
Ilagan-Ying Y, Almeida M, Kahler-Quesada A, Ying L, Do A, Hughes M, Hung K. S0564 Understanding the Impact of the COVID-19 Pandemic on Inpatient Gastrointestinal Procedures: A Single Center Study. The American Journal Of Gastroenterology 2020, 115: s259-s259. DOI: 10.14309/01.ajg.0000704304.38893.a6.Peer-Reviewed Original ResearchCorrelating actual one-year weight loss with predicted weight loss by the MBSAQIP: bariatric surgical risk/benefit calculator
Zhou R, Ying L, Valle J, Moore J, Nadzam G, Roberts K, Ghiassi S, Morton J, Duffy A. Correlating actual one-year weight loss with predicted weight loss by the MBSAQIP: bariatric surgical risk/benefit calculator. Surgical Endoscopy 2020, 35: 5705-5708. PMID: 32968922, DOI: 10.1007/s00464-020-08030-4.Peer-Reviewed Original ResearchConceptsHigher preoperative BMIBariatric surgeryWeight lossActual weight lossPreoperative BMIOne-year weight lossYale-New Haven HospitalNational databasePatient preoperative informationMethodsA retrospective reviewBody mass indexBackgroundThe American SocietyNew Haven HospitalUnpaired t-testObese patientsPatient factorsRetrospective reviewMass indexPreoperative discussionPreoperative informationBMI pointsBMIPatientsInformed consentSurgery
2019
Measuring Uncertainty Intolerance in Surgical Residents Using Standardized Assessments
Ying LD, Harrington A, Assi R, Thiessen C, Contessa J, Hubbard M, Yoo P, Nadzam G. Measuring Uncertainty Intolerance in Surgical Residents Using Standardized Assessments. Journal Of Surgical Research 2019, 245: 145-152. PMID: 31419639, DOI: 10.1016/j.jss.2019.07.035.Peer-Reviewed Original ResearchConceptsPhysicians' risk attitudesUncertainty intoleranceNew education initiativeMBTI assessmentPersonality factorsFemale residentsSurgical residentsPras scoreOwn mental healthMale residentsUncertainty toleranceGeneral surgery residentsHigher completion ratesStages of trainingPsychological stressMental healthSurgical practiceLarger studyStandardized assessmentPhysician practicesPilot studySurgery residentsSuch interventionsPRUSignificant differencesIntraoperative Blood Pressure Lability Is Associated with Postoperative Hemorrhage after Uncomplicated Bariatric Surgery
Ying LD, Duffy AJ, Roberts KE, Ghiassi S, Hubbard MO, Nadzam GS. Intraoperative Blood Pressure Lability Is Associated with Postoperative Hemorrhage after Uncomplicated Bariatric Surgery. Obesity Surgery 2019, 29: 1990-1994. PMID: 30895505, DOI: 10.1007/s11695-019-03839-y.Peer-Reviewed Original ResearchConceptsPostoperative hemorrhageKetorolac administrationBariatric surgeryBlood pressurePressure labilityPre-operative blood pressureRetrospective case-control studyHigh-volume academic centersPerioperative medication administrationBariatric surgery patientsBlood pressure labilityCase-control studyType of procedurePostoperative bleedingRare complicationSurgery patientsMedication administrationAbdominal contentsAcademic centersHemorrhageLower MAPSurgeryAdministrationEnoxaparinPatients
2018
Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition
Ying LD, Breuer GA, Hubbard MO, Nadzam GS, Hwa J, Martin KA. Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition. Obesity Surgery 2018, 29: 593-600. PMID: 30353248, PMCID: PMC6365182, DOI: 10.1007/s11695-018-3555-7.Peer-Reviewed Original ResearchConceptsIleal transpositionSleeve gastrectomySham surgeryMouse modelReproducible mouse modelIntestinal identityQuantitative polymerase chain reactionBackgroundSleeve gastrectomySham procedureC57BL/6J miceObesogenic dietPolymerase chain reactionGastrectomyMurine modelPorcine modelWeight gainWeight lossMiceChain reactionMolecular pathwaysGene expression analysisWeeksFuture studiesLong-term survivabilityTechnical feasibility
2017
Impact of preoperative wait time due to insurance-mandated medically supervised diets on weight loss after sleeve gastrectomy. Are patients losing momentum?
Ying LD, Duffy AJ, Roberts KE, Ghiassi S, Hubbard MO, Nadzam GS. Impact of preoperative wait time due to insurance-mandated medically supervised diets on weight loss after sleeve gastrectomy. Are patients losing momentum? Surgery For Obesity And Related Diseases 2017, 13: 1584-1589. PMID: 28663074, DOI: 10.1016/j.soard.2017.05.017.Peer-Reviewed Original ResearchConceptsPostoperative weight lossPreoperative wait timePreoperative weight lossWeight lossSleeve gastrectomyPreoperative dietPreoperative periodSurgical weight loss programShorter preoperative periodRetrospective chart reviewDay of surgeryWeight loss programGreater weight lossAcademic medical centerWait timeLifestyle modificationChart reviewConsecutive patientsPostoperative percentageSingle surgeonReduction dietLoss programEarly initiationMedical CenterNet weight loss
2015
Androgens Attenuate Vitamin D Production Induced by UVB Irradiation of the Skin of Male Mice by an Enzymatic Mechanism.
Xue Y, Ying L, Horst RL, Watson G, Goltzman D. Androgens Attenuate Vitamin D Production Induced by UVB Irradiation of the Skin of Male Mice by an Enzymatic Mechanism. The Journal Of Investigative Dermatology 2015, 135: 3125-3132. PMID: 26214382, DOI: 10.1038/jid.2015.297.Peer-Reviewed Original Research
2014
Cardiovascular pharmacogenetics of anti-thrombotic agents and non-steroidal anti-inflammatory drugs.
Stitham J, Vanichakarn P, Ying L, Hwa J. Cardiovascular pharmacogenetics of anti-thrombotic agents and non-steroidal anti-inflammatory drugs. 2014, 14: 909-31. PMID: 25109796, DOI: 10.2174/1566524014666140811121109.Peer-Reviewed Original ResearchConceptsNon-steroidal anti-inflammatory drugsAnti-inflammatory drugsCardiovascular pharmacogeneticsAdverse cardiovascular eventsAppropriate treatment regimenAnti-thrombotic agentsNSAID therapyCardiovascular eventsThromboembolic eventsCardiovascular implicationsCardiovascular riskPoor respondersTreatment regimenProspective screeningMyocardial infarctionAdverse reactionsAntithrombotic agentsCardiovascular diseaseHealthcare providersDrug efficacyGenetic biomarkersMedicationsIndividualized predictionInter-individual variationDrugs