2003
MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder
Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Nazeer A, Khan S, Vaccarino LV, Soufer R, Garg PK, Ng CK, Staib LH, Duncan JS, Charney DS. MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder. American Journal Of Psychiatry 2003, 160: 924-932. PMID: 12727697, DOI: 10.1176/appi.ajp.160.5.924.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderChildhood sexual abuseHippocampal volumeEarly childhood sexual abuseHippocampal structureHippocampal functionAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesPositron emission tomographySexual abuseVerbal declarative memory tasksAnimal studiesBrain areasDeclarative memory taskEmission tomographyPET studiesHippocampal activationWomenEarly stressHippocampusAbused womenDisordersAbuseMagnetic resonanceNeural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse
Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Staib LH, Soufer R, Charney DS. Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse. Biological Psychiatry 2003, 53: 879-889. PMID: 12742675, DOI: 10.1016/s0006-3223(02)01891-7.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAbuse-related posttraumatic stress disorderMedial prefrontal cortexBrain areasPrefrontal cortexEarly childhood sexual abuseBlood flowChildhood abuse-related posttraumatic stress disorderSexual abuse-related posttraumatic stress disorderStress disorderChildhood sexual abuseCerebral blood flowPositron emission tomographic measurementsSpecific brain areasInferior temporal gyrusInferior parietal cortexMiddle frontal gyrusNeural correlatesTrauma-specific stimuliDeclarative memoryMotor cortexControl subjectsFrontal cortexSymptom provocationAnimal studies
1999
Neural Correlates of Memories of Childhood Sexual Abuse in Women With and Without Posttraumatic Stress Disorder
Bremner J, Narayan M, Staib L, Southwick S, McGlashan T, Charney D. Neural Correlates of Memories of Childhood Sexual Abuse in Women With and Without Posttraumatic Stress Disorder. American Journal Of Psychiatry 1999, 156: 1787-1795. PMID: 10553744, PMCID: PMC3233772, DOI: 10.1176/ajp.156.11.1787.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderBlood flowVisual association cortexMedial prefrontal cortexChildhood sexual abusePrefrontal cortexMotor cortexAssociation cortexPosterior cingulateStress disorderBrain blood flowChildhood abuseInferior temporal gyrusPositron emission tomographyNeural correlatesSexual abuseSubcallosal gyrusRight hippocampusLong-term effectsFailure of activationAnterior prefrontal cortexBrain areasAnterior cingulateTraumatic remindersEmission tomography
1997
Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison region