2024
In vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjectsReliable Prostate Cancer Risk Mapping From MRI Using Targeted and Systematic Core Needle Biopsy Histopathology
Zeevi T, Leapman M, Sprenkle P, Venkataraman R, Staib L, Onofrey J. Reliable Prostate Cancer Risk Mapping From MRI Using Targeted and Systematic Core Needle Biopsy Histopathology. IEEE Transactions On Biomedical Engineering 2024, 71: 1084-1091. PMID: 37874731, PMCID: PMC10901528, DOI: 10.1109/tbme.2023.3326799.Peer-Reviewed Original ResearchMagnetic resonance imagingIndividual patientsBiopsy locationProstate biopsy dataBiopsy histopathologyHistopathology scoresPathology scoresBiopsy dataMRI biomarkersTreatment planPatientsResonance imagingProstate regionBiomarkersTherapy treatment plansPathologyRepresentative sampleScoresImaging analysisPrevious studiesHistopathologyProstateCancerClinicians
2022
Machine Learning Applications for Differentiation of Glioma from Brain Metastasis—A Systematic Review
Jekel L, Brim WR, von Reppert M, Staib L, Petersen G, Merkaj S, Subramanian H, Zeevi T, Payabvash S, Bousabarah K, Lin M, Cui J, Brackett A, Mahajan A, Omuro A, Johnson MH, Chiang VL, Malhotra A, Scheffler B, Aboian MS. Machine Learning Applications for Differentiation of Glioma from Brain Metastasis—A Systematic Review. Cancers 2022, 14: 1369. PMID: 35326526, PMCID: PMC8946855, DOI: 10.3390/cancers14061369.Peer-Reviewed Original ResearchBrain metastasesDifferentiation of gliomasMagnetic resonance imagingEligible studiesSystematic reviewSingle-center institutionConventional magnetic resonance imagingSpecific clinical circumstancesNon-invasive differentiationQuality of reportingClinical circumstancesPoor reportingClinical practiceModel assessmentResonance imagingMetastasisStudy designGliomasTRIPOD StatementMultiple studiesExternal validationClinical translationAdherenceDifferentiationReview
2015
Utility of Magnetic Resonance Imaging in the Evaluation of Intraoperatively Confirmed Pelvic Adhesions
Macer ML, Mathur M, Spektor M, Gysler S, Staib L, Kodaman P, McCarthy S. Utility of Magnetic Resonance Imaging in the Evaluation of Intraoperatively Confirmed Pelvic Adhesions. Journal Of Computer Assisted Tomography 2015, 39: 896-900. PMID: 26466105, DOI: 10.1097/rct.0000000000000302.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPelvic adhesionsPositive predictive valuePredictive valueResonance imagingSpecificity of MRIGynecologic abdominal surgeryInstitutional review board-approved retrospective analysisNegative predictive valueAnterior culPosterior culAbdominal surgeryOperative reportsInclusion criteriaRetrospective analysisStudy populationBlinded specialistsMRI sensitivityPatientsImaging
2004
Estimation of Anatomical Connectivity by Anisotropic Front Propagation and Diffusion Tensor Imaging
Jackowski M, Kao C, Qiu M, Constable R, Staib L. Estimation of Anatomical Connectivity by Anisotropic Front Propagation and Diffusion Tensor Imaging. Lecture Notes In Computer Science 2004, 3217: 663-670. DOI: 10.1007/978-3-540-30136-3_81.Peer-Reviewed Original ResearchFront arrival timesFront propagationAnisotropic front propagationMagnetic resonance imagingNormal human brainDiffusion tensor imagingDiffusion tensor magnetic resonance imagingAnisotropic versionWhite matterPropagation methodResonance imagingAnatomical connectivityFibrous tissueTensor imagingDiffusion tensorHuman brainSweeping methodArrival timeBrain
2002
Reduced volume of orbitofrontal cortex in major depression
Bremner JD, Vythilingam M, Vermetten E, Nazeer A, Adil J, Khan S, Staib LH, Charney DS. Reduced volume of orbitofrontal cortex in major depression. Biological Psychiatry 2002, 51: 273-279. PMID: 11958777, DOI: 10.1016/s0006-3223(01)01336-1.Peer-Reviewed Original ResearchConceptsMajor depressionOrbitofrontal cortexOrbitofrontal cortical volumeCortical volumeArea 32Area 24Brodmann's area 32Recent postmortem studiesWhole brain volumeSymptoms of depressionBrodmann's area 24Magnetic resonance imagingFrontal cortical regionsFunctional neuroimaging studiesSubcallosal gyrusDepressed patientsPostmortem studiesCortical subregionsComparison subjectsBrain volumePatientsResonance imagingCortical regionsCortexNeuroimaging studies
2000
Temporal lobe volume in panic disorder — a quantitative magnetic resonance imaging study
Vythilingam M, Anderson E, Goddard A, Woods S, Staib L, Charney D, Bremner J. Temporal lobe volume in panic disorder — a quantitative magnetic resonance imaging study. Psychiatry Research 2000, 99: 75-82. PMID: 10963983, DOI: 10.1016/s0925-4927(00)00055-x.Peer-Reviewed Original ResearchConceptsTemporal lobe volumePanic disorderTemporal lobeMagnetic resonance imagingControl subjectsHealthy subjectsLobe volumeSmaller temporal lobe volumeNormal hippocampal volumesMagnetic resonance imaging studyHealthy control subjectsRight temporal lobeQuantitative magnetic resonance imaging studyQuantitative MRI measuresWhole brain volumeResonance imaging studyHippocampal volumeBrain changesMRI measuresBrain volumeWhole brainPatientsQualitative abnormalitiesResonance imagingImaging studiesHippocampal Volume Reduction in Major Depression
Bremner J, Narayan M, Anderson E, Staib L, Miller H, Charney D. Hippocampal Volume Reduction in Major Depression. American Journal Of Psychiatry 2000, 157: 115-118. PMID: 10618023, DOI: 10.1176/ajp.157.1.115.Peer-Reviewed Original ResearchConceptsSmaller left hippocampal volumeLeft hippocampal volumeHippocampal volumeMajor depressionComparison subjectsHippocampal volume reductionWhole brain volumeMagnetic resonance imagingNondepressed comparison subjectsAlcohol exposureBrain areasBrain volumeResonance imagingPatientsElevated levelsDepressionHippocampusVolume reductionComparison regionBrain sizeSubjectsRemissionGlucocorticoidsFindings
1998
Development and Reliability of a Method for Using Magnetic Resonance Imaging for the Definition of Regions of Interest for Positron Emission Tomography
Bremner JD, Bronen RA, De Erasquin G, Vermetten E, Staib LH, Ng CK, Soufer R, Charney DS, Innis RB. Development and Reliability of a Method for Using Magnetic Resonance Imaging for the Definition of Regions of Interest for Positron Emission Tomography. Molecular Imaging And Biology 1998, 1: 145-159. PMID: 14516589, DOI: 10.1016/s1095-0397(98)00015-6.Peer-Reviewed Original ResearchMagnetic resonance imagingPositron emission tomographyCoregistered magnetic resonance imagingResonance imagingBrain regionsEmission tomographyPoor anatomical resolutionAnatomical resolutionRegional metabolic rateBrain metabolic rateIntra-class correlation coefficientSuperior anatomical resolutionPET scansMRI scansMetabolic rateBrain scansPhysiologic informationAnatomical landmarksPET brain imagesReliable methodPets siteIndependent ratersScansImportant physiological informationStandard anatomical atlas
1997
Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison region